1994-1998 西安交通大学 化工学院 学士
1998-2001 天津大学 化工学院 硕士
2001-2004 北京大学 药学院 博士
2004-2006 美国罗得岛大学 药学院 博士后
2006-2008 美国罗彻斯特大学 化学系 博士后
2009-2012 复旦大学 药学院药物化学系 讲师
2012-2019 复旦大学 药学院药物化学系 副教授
2019- 至今 复旦大学 药学院药物化学系 教授
1.代谢免疫性疾病及心脑血管系统疾病的预防和治疗药物的研究与开发
2.生物分子及细胞信号通路荧光探针的设计合成及生物学应用
1. 国家自然科学基金面上项目（82173657, 主持, 在研）
2.国家自然科学基金面上项目（21977018, 主持, 已结题）
3. 国家自然科学基金面上项目（21572039, 主持, 已结题）
4. 上海市科委科技创新计划（15401901900, 主持, 已结题）
5. 国家自然科学基金青年项目(21002013, 主持, 已结题)
6. 上海市科委科技创新项目（10431903200，主持，已结题）
7. 教育部留学回国人员启动基金 (主持, 已结题）
8. 其他企事业单位合作项目
2017年复旦大学上药中西奖教金
1. Ziwen Zhang; Hongyu Wu; Kai Yin; Xinru Zheng; Zhonglian Cao; Wei Guo*; Chunchang Zhao; Xianfeng Gu* Design, Synthesis, and Bioevaluation of Novel NLRP3 Inhibitor with IBD Immunotherapy from the Virtual Screen, Journal of Medicinal Chemistry, 2024, ASAP
2. Zhirong Ouyang; Muye Ma; Ziwen Zhang; Hongyu Wu; Yongxing Xue; Yuting Jian; Kai Yin; Shaokun Yu; Chunchang Zhao; Wei Guo*; Xianfeng Gu*; Targeted Degradation of PCSK9 In Vivo by Autophagy-Tethering Compounds, Journal of Medicinal Chemistry, 2024, 67: 433-449.
3. Xuemei Dong; Hongyu Wu; Ziwen Zhang; Jie Sun; Chengjun Dong; Lixin Sun; Rongchen Wang*; Xianfeng Gu*; Chunchang Zhao* Depletion and Downregulation of Hydrogen Sulfide Using an Activatable Probe for Promoting Photothermal Therapy toward Colorectal Cancers, Journal of Medicinal Chemistry 2024, 67:7431-7442.
4. Kai Yin; Ziwen Zhang; Yanqing Mo; Hongyu Wu; Zhonglian Cao; Yongxing Xue; Mingrunlin Wang; Wei Guo*; Li Feng*; Chunchang Zhao; Xianfeng Gu* Discovery of Autophagy-tethering Compounds as Potent NLRP3 Degraders for IBD Immunotherapy. European Journal of Medicinal Chemistry 2024, 275:116581.
5. Zehua Qian; Lixin Sun; Rongchen Wang; Xuemei Dong; Jie Sun; Chengjun Dong; Dahui Qu*; Xianfeng Gu*; Chunchang Zhao* High-fidelity spatiotemporal recognition of Golgi AlP through an initial-accumulation and post-activation strategy, Analytical Chemistry, 2024, 96(23):9737-9743.
6. Zhecha Zheng; Jinzhu Gao; Rongchen Wang; Chengjun Dong; Xuemei Dong; Jie Sun; Lixin Sun; Xianfeng Gu*; Chunchang Zhao*; Molecular Engineering of Luminogens for High-Integrity Imaging of Hydrogen Polysulfides via Activatable Aggregation-Induced Dual-Color Fluorescence, ACS Nano, 2023, 17: 22060- 22070.
7. Jie Sun; Ning Cheng; Kai Yin; Rongchen Wang; Tianli Zhu; Jinzhu Gao; Xuemei Dong; Chengjun Dong; Xianfeng Gu*; Chunchang Zhao*Activatable photothermal agents with target initiated large spectral separation for highly effective reduction of side effects, Chemical Science, 2022, 13(33): 9525-9530.
8. Rongchen Wang, Kai Yin, Muye Ma, Tianli Zhu, Jinzhu Gao, Jie Sun, Xuemei Dong, Chengjun Dong, Xianfeng Gu*, He Tian and Chunchang Zhao* Alkaline Phosphatase-Initiated Sensitive Responsiveness of Activatable Probes to Hydrogen Sulfide for Accurate Cancer Imaging and Differentiation. CCS Chemistry 2022, 4:3715-3723.
9. Jiahui Tan; Kai Yin; Zhirong Ouyang; Rongchen Wang; Hongming Pan; Zhijun Wang; Chuchang Zhao; Wei Guo*; Xianfeng Gu*; Real-Time Monitoring Renal Impairment Due to Drug-Induced AKI and Diabetes-Caused CKD Using an NAG Activatable NIR-II Nanoprobe, Analytical Chemistry, 2021, 93: 16158-16165.
10. Ji-An Chen; Wei Guo; Zhijun Wang; Nannan Sun; Hongmin Pan; Jiahui Tan; Zhirong Ouyang; Wei Fu; Yonghui Wang; Wei Hu*; Xianfeng Gu*; In Vivo Imaging of Senescent Vascular Cells in Atherosclerotic Mice Using a beta Galactosidase-Activatable Nanoprobe, Analytical Chemistry, 2020, 92: 12613- 12621.
