个人简介
丁宁，复旦大学药学院教授，博士生导师。入选上海市人力资源与社会保障局人才发展基金、复旦大学卓学计划。兼任上海药学会药物化学专委会委员、上海市药物和医疗器械不良反应监测中心涉案药品风险评估专家、中国生物物理学会糖生物学分会委员。
课题组在药物化学领域，以“糖类药物”为目标，“糖化学”为基础，“糖生物学”为依托，围绕着具有潜在治疗用途的寡糖/糖苷的高效合成及生物活性评价与应用进行研究。研究工作获国家新药创制重大专项、国家自然科学基金、上海市生物医药专项等二十余项国家、省部级、企业横向课题的资助；累计发表研究论文80余篇；授权中国发明专利多项。
参编“十二五”高等教育本科国家级规划教材《药物化学》第五版（化学工业出版社）；主讲本科生课程《药物化学》（国家级一流本科课程/上海市精品课程/上海市教委本科重点建设课程/复旦大学思政标杆课程）、《化学生物学导论》部分章节并带教《有机化学实验I & II》等；主讲研究生课程《糖化学》、《药物化学进展》及《高等药物化学》部分章节等。
教育经历
2004 – 2007，中国海洋大学医药学院，教育部海洋药物重点实验室，博士
2001 – 2004，中国海洋大学医药学院，教育部海洋药物重点实验室，硕士
1997 – 2001，中国海洋大学水产学院，药物化学专业，学士
2009 – 今， 复旦大学药学院药物化学系，历任讲师、副教授、教授
（其中：2014 – 2016，佐治亚大学复杂碳水化合物研究中心，访问学者）
2007 – 2008，普度大学化学系，博士后
1.国家自然科学基金面上项目（主持）。
2.新药创制重大专项（主持）。
3.上海市科委“科技创新行动计划”生物医药领域科技支撑项目（主持）。
4.上海市人才发展资金（主持）。
5.国家自然科学基金青年项目（主持）。
6. 临港实验室项目（参与）。
7.技术开发与技术服务项目。
上海市人才发展资金
复旦大学卓学计划
复旦大学第一三共制药奖教金
复旦大学德传奖教金
复旦大学上海医学院第四届课程思政教案大赛二等奖
复旦大学青年教师讲课比赛（医科组）二等奖
复旦大学药学院青年教师讲课比赛一等奖
糖类药物化学
1. Yujing Shen, Yuning Wei, Weizhao Weng, Chunxia Yang, Chuanjun Wu, Xuyuan Liu, Xishan Xu, Jianping Qi*, Wei Zhang*, Ning Ding*. Quercetin glycoside-incorporated lipid nanoparticles for mRNA delivery exhibit reduced inflammatory response. Chemical Engineering Journal, 2026, 536, 176034 (https://doi.org/10.1016/j.cej.2026.176034).
2. Weiwen Kong, Zirong Dong, Yuning Wei, Wenjuan Liu, Shuyan Li, Yue Yang, Ning Ding, Jinlong Yang*, Jianping Qi*. Microbial rhamnolipid-stabilized mRNA nanovaccines enhance adaptive immunity via dendritic cell targeting. Advanced Functional Materials, 2026, 0: e31454 (https://doi.org/10.1002/adfm.202531454).
3. Jiangzhu Zhan; Lijun Xu; Shuaibing Ding; Ning Ding*, Wei Zhang*. Novel trimethyl lock-based prostate-specific membrane antigen targeted Conjugates: Design, synthesis, and biological activity evaluation. European Journal of Medicinal Chemistry, 2025, 296, 117857 (https://doi.org/10.1016/j.ejmech.2025.117857).
4. Hongming Cai, Xinyu Wu, Shixin Jin, Yubin Liu, Xuyuan Liu, Kuaile Lin*, Ning Ding*. Design, synthesis, and application of triazole-embedded maltose-neopentyl-glycol (TMNG) amphiphiles for membrane protein studies. Carbohydrate Research, 2025, 555, 109560 (https://doi.org/10.1016/j.carres.2025.109560).
5. Qiuyu Guo, Chunxia Yang, Xuyuan Liu, Jian Liu, Wei Zhang, Xiuhong Lu*, Ning Ding*. Construction of PROTAC molecules by the SuFEx reaction for inducing p300/CBP protein degradation. Bioorganic & Medicinal Chemistry, 2025, 125, 118201 (https://doi.org/10.1016/j.bmc.2025.118201).
6. Ying Xu, Jing Yang, Xiongyan Meng, shuai Meng, Tiantian Sun*, Ning Ding*, Chengli Zong*. The synthesis and preliminary immunological evaluation of a dual-adjuvant SARS-COV-2 RBD vaccine: Covalent integration of TLR7/8 and iNKT cell agonists. International Journal of Biological Macromolecules, 2024, 270, 132258 (https://doi.org/10.1016/j.ijbiomac.2024.132258).
7. Xiongyan Meng, Ying Xu, Jing Yang, Shuai Meng, Ning Ding, Tiantian Sun, Chengli Zong*. Strategic development of a self-adjuvanting SARS-CoV-2 RBD vaccine: From adjuvant screening to enhanced immunogenicity with a modified TLR7 agonist. International Immunopharmacology, 2024, 132, 111909 (https://doi.org/10.1016/j.intimp.2024.111909).
8. Zhaolin Wang; Bin Zhu; Fan Jiang; Xiangping Chen; Guangfa Wang; Ning Ding; Shaoli Song; Xiaoping Xu, Wei Zhang*. Design, synthesis and evaluation of novel prostate-specific membrane antigen-targeted aryl [18F]fluorosulfate PET tracers. Bioorganic & Medicinal Chemistry, 2024, 106, 117753 (DOI: 10.1016/j.bmc.2024.117753).
9. Weizhao Weng, Sumei Ren, Changcai Teng, Jia Guo, Qiuyu Guo, Wei Zhang, Chengli Zong* and Ning Ding*. Chemoenzymatic synthesis and immunological evaluation of sialyl-Thomsen-Friedenreich (sTF) antigen conjugate to CRM197. Bioorganic & Medicinal Chemistry, 2024, 100, 117615 (https://doi.org/10.1016/j.bmc.2024.117615).
10. Jiahao Xie, Fangzhou Lan, Xuyuan Liu, Weizhao Weng, and Ning Ding*. The synthesis of fluorinated carbohydrates using sulfuryl fluoride (SO2F2) as the deoxyfluorination reagent. Organic Letters, 2023, 25, 3796–3799 (https://doi.org/10.1021/acs.orglett.3c01305).
11. Xianglai Liu, Yingying Song, Ao Liu, Yueer Zhou, Qian Zhu, Yetong Lin, Huiyong Sun, Kaidi Zhu, Wei Liu, Ning Ding, Weijia Xie, Haopeng Sun, Biao Yu, Peng Xu,* Wei Li*. More than a leaving group: N-phenyltrifluoroacetimidate as a remote directing group for highly α-selective 1,2-cis glycosylation. Angewandte Chemie International Edition, 2022, 134, e202201510 (https://doi.org/10.1002/anie.202201510).
12. Tiantian Sun, Shiyan Mai, Hongzhao Mao, Huiting Li, Yunyao Duan, Shuai Meng, Jiaolin Bao, Ning Ding, Chengli Zong*. Conjugate of structurally reassigned pneumococcal serotype 31 polysaccharide with CRM197 elicited potent immune response. Carbohydrate polymers, 2022, 289, 119414 (https://doi.org/10.1016/j.carbpol.2022.119414).
13. Yulong He, Mengting Chen, Ting Wang, Mingming Zhang, Yingxa Li*, Heyao Wang*, Ning Ding*. Development of FABP4/5 inhibitors with potential therapeutic effect on Type 2 Diabetes Mellitus. European Journal of Medicinal Chemistry, 2021, 224, 11370 (https://doi.org/10.1016/j.ejmech.2021.113720).
14. Sumei Ren, Minmin Zhang, Yujie Wang, Jia Guo, Junfei Wang, Yingxia Li, Ning Ding*. Synthesis and bological evaluation of novel Cabazitaxel analogues. Bioorganic & Medicinal Chemistry, 2021, 41, 116224 (https://doi.org/10.1016/j.bmc.2021.116224).
15. Ke Xu, Qingmin Man, Yang Zhang, Jia Guo, Yichu Liu, Zunyun Fu, Yueyue Zhu, Yingxia Li, Mingyue Zheng*, Ning Ding*. Investigation of the remote acyl group participation in glycosylation from conformational perspectives by using trichloroacetimidate as the acetyl surrogate. Organic Chemistry Frontiers, 2020, 7, 1606-1615 (DOI: 10.1039/d0qo00363h).
