个人简介
丁宁，教授，博士生导师。中国生物物理学会糖生物学分会委员。课题组在药物化学领域，以“糖类药物”为目标，“糖化学”为基础，“糖生物学”为依托，围绕着具有潜在生物活性的寡糖/糖苷的高效合成及生物活性评价与应用进行研究。研究工作获国家新药创制重大专项、国家自然科学基金、上海市生物医药专项等十余项国家、省部级、企业横向课题的资助；累计发表研究论文70余篇。主讲本科生课程《药物化学》（上海市精品课程/上海市教委本科重点建设课程/复旦大学思政标杆课程）、《化学生物学导论》部分章节并带教《有机化学实验I&II》等；主讲研究生课程《糖化学》、《药物化学进展》及《高等药物化学》部分章节等。
教育经历
2004 – 2007，中国海洋大学医药学院，教育部海洋药物重点实验室，博士
2001 – 2004，中国海洋大学医药学院，教育部海洋药物重点实验室，硕士
1997 – 2001，中国海洋大学水产学院，药物化学专业，学士
2009 – 今， 复旦大学药学院药物化学系，历任讲师、副教授、教授
（其中：2014 – 2016，佐治亚大学复杂碳水化合物研究中心，访问学者）
2007 – 2008，普度大学化学系，博士后
1. 国家自然科学基金面上项目。
2. 新药创制重大专项。
3. 上海市科委“科技创新行动计划”生物医药领域科技支撑项目。
4. 上海市人才发展资金。
5. 国家自然科学基金青年项目。
6. 企业横向课题。
糖类药物化学
1. The synthesis and preliminary immunological evaluation of a dual-adjuvant SARS-COV-2 RBD vaccine: Covalent integration of TLR7/8 and iNKT cell agonists. International Journal of Biological Macromolecules, 2024, 132258.
2. Strategic development of a self-adjuvanting SARS-CoV-2 RBD vaccine: From adjuvant screening to enhanced immunogenicity with a modified TLR7 agonist. International Immunopharmacology, 2024, 132, 111909.
3. Design, synthesis and evaluation of novel prostate-specific membrane antigen-targeted aryl [18F]fluorosulfate PET tracers. Bioorganic & Medicinal Chemistry, 2024, 106, 117753.
4. Chemoenzymatic synthesis and immunological evaluation of sialyl-Thomsen-Friedenreich (sTF) antigen conjugate to CRM197. Bioorganic & Medicinal Chemistry, 2024, 100, 117615.
5. The synthesis of fluorinated carbohydrates using sulfuryl fluoride (SO2F2) as the deoxyfluorination reagent. Organic Letters, 2023, 25, 3796–3799.
6. More than a leaving group: n-phenyltrifluoroacetimidate as a remote directing group for highly α-selective 1,2-cis glycosylation. Angewandte Chemie International Edition, 2022, 134, e202201510.
7. Conjugate of structurally reassigned pneumococcal serotype 31 polysaccharide with crm197 elicited potent immune response. Carbohydrate polymers, 2022, 289, 119414.
8. Development of FABP4/5 inhibitors with potential therapeutic effect on Type 2 Diabetes Mellitus. European Journal of Medicinal Chemistry, 2021, 224, 11370.
9. Synthesis and bological evaluation of novel Cabazitaxel analogues. Bioorganic & Medicinal Chemistry, 2021, 41, 116224.
10. Investigation of the remote acyl group participation in glycosylation from conformational perspectives by using trichloroacetimidate as the acetyl surrogate. Organic Chemistry Frontiers, 2020, 7, 1606-1615.
11. Improving dermal delivery of hyaluronic acid by ionic liquids for attenuating skin dehydration. International Journal of Biological Macromolecules, 2020, 150, 528–535.
12. Synthesis and biological evaluation of Ginsenoside compound K analogues as a novel class of anti-asthmatic agents. Bioorganic & Medicinal Chemistry Letters, 2019, 29, 51-55.
13. Glycosylation of a ketone with an O-glycosyl trichloroacetimidate provides an enol glycoside. Organic Letters, 2018, 20, 5186-5189.
14. Synthesis and biological evaluation of novel larotaxel analogues. European Journal of Medicinal Chemistry, 2018, 156, 692-710.
15. Tracking translocation of self-discriminating curcumin hybrid nanocrystals following intravenous delivery. International Journal of Pharmaceutics, 2018, 546, 10-19.
16. Discovery of novel 2,4-diarylaminopyrimidine derivatives as potent and selective epidermal growth factor receptor (EGFR) inhibitors against L858R/T790M resistance mutation. European Journal of Medicinal Chemistry, 2018, 152, 298-306.
17. Synthesis of a glycosylphosphatidylinositol anchor derived from Leishmania donovani that can be functionalized by Cu-catalyzed azide-alkyne cycloadditions. Organic Letters, 2017, 19, 3827−3830.
18. A comparison of benzyl and 2-naphthylmethyl ethers as permanent hydroxyl protecting groups in the synthesis of α-galactoglycosphingolipids KRN7000 and PBS-57. Journal of Carbohydrate Chemistry, 2017, 36, 173-188.
19. Evidence of robust participation by an equatorial 4-O group in glycosylation on a 2-azido-2-deoxy-glucopyranosyl donor. Chemical Communications, 2017, 53, 2986-2989.
20. Rapid access to 6”-functionalized α-galactosyl ceramides by using 2-naphthylmethyl ether as the permanent protecting group. Bioorganic & Medicinal Chemistry Letters, 2017, 27, 1795-1798.
