1982.09-1989.07 山东海洋学院化学系，学士/硕士
1993.09-1999.06 青岛海洋大学药学系，博士
1995.10-1998.04 日本大阪大学，交换博士生
1989.08-1998.12 青岛海洋大学，助教/讲师/副教授
2001.12-2009.05 中国海洋大学,教授
2009.6 – 现在 复旦大学药学院，教授
上海市优秀学科带头人
1. 国家自然科学基金面上项目，抗糖尿病特异性FABP4/5双靶标的抑制剂发现与功能确证（2020-2023）
2. 新药创制专项子课题任务，新型STAT3小分子抑制剂的成药性研究（2018-2020）
3. 海洋重大研究计划课题，深海动植物药物先导化合物的规模化全合成与优化（2018-2020）
4. 上海市生物医药领域科技支撑项目，新型脂肪酸结合蛋白 4小分子抑制剂的临床前研究（2018-2020）
5. 自然科学基金面上项目，基于海洋聚酮PM060184的新一代微管蛋白抑制剂的研究（2018-2021）
1. 基于靶标结构的药物设计与优化，主要包括抗肿瘤和代谢调节性小分子药物
2. 基于活性天然产物的成药性优化
2019.08 – 现在 中国药学会药物化学业委员会委员
2019.01 – 现在 上海市海洋药物专业委员会委员
2019.10 – 现在 上海市药物化学专业委员会副主任委员
《中国药物化学杂志》、《海洋药物》、《国际药学杂志》和Frontiers杂志的编委
1. Chang, Qi; Li, Jiayi; Deng, Yue; Zhou, Ruilin; Wang, Bingwei; Wang, Yujie; Zhang, Mingming; Huang, Xun*; Li, Yingxia*. Discovery of Novel PROTAC Degraders of p300/CBP as Potential Therapeutics for Hepatocellular Carcinoma. Journal of Medicinal Chemistry 2024, 67, 4, 2466-2486.
2. He, Yulong; Li, Shunyi; Zhu, Yueyue; Wang, Yujie; Chen, Yuqi; Zhang, Deqiang; Wang, Heyao; Li, Yingxia, Optimization of potent, selective and orally bioavailable biphenyl scaffold as FABP4 inhibitors for anti-inflammation. European Journal of Medicinal Chemistry 2023, 253, 115319.
3. Wang, Xianyang; Wang, Yujie; Zhu, Yueyue; Lei, Xinsheng; Zhang, Mingming; Li, Yingxia, Identification and immunological evaluation of novel TLR2 agonists through structural optimization of Diprovocim. European Journal of Medicinal Chemistry 2022, 243, 114771.
4. Liu, Ruiqi; Yang, Hong; Chen, Zonglong; Zhou, Kaixin; Shi, Qiongyu; Li, Jiayi; Huang, Yuting; Huang, Xun; Li, Yingxia, Design, synthesis and biological evaluation of (R)-5-methylpyrrolidin-2-ones as p300 bromodomain inhibitors with Anti-Tumor activities in multiple tumor lines. Bioorganic Chemistry 2022, 124, 105803.
5. Chen, Zonglong; Li, Jiayi; Yang, Hong; He, Yulong; Shi, Qiongyu; Chang, Qi; Liu, Ruiqi; Huang, Xun; Li, Yingxia, Discovery of novel benzimidazole derivatives as potent p300 bromodomain inhibitors with anti-proliferative activity in multiple cancer cells. Bioorganic & Medicinal Chemistry 2022, 66, 116784.
6. Gao, Dingding; Jin, Nan; Fu, Yixian; Zhu, Yueyue; Wang, Yujie; Wang, Ting; Chen, Yuehong; Zhang, Mingming; Xiao, Qiang; Huang, Min; Li, Yingxia, Rational drug design of benzothiazole-based derivatives as potent signal transducer and activator of transcription 3 (STAT3) signaling pathway inhibitors. European Journal of Medicinal Chemistry 2021, 216, 113333.
7. Ren, Sumei; Zhang, Minmin; Wang, Yujie; Guo, Jia; Wang, Junfei; Li, Yingxia; Ding, Ning, Synthesis and biological evaluation of novel cabazitaxel analogues. Bioorganic & Medicinal Chemistry 2021, 41, 116224.
8. Liu, Yichu; Wang, Yibing; Dai, Wenhao; Huang, Wei; Li, Yingxia; Liu, Hong, Palladium-Catalysed C(sp3)-H Glycosylation for the Synthesis of C-Alkyl Glycoamino Acids. Angewandte Chemie International Edition 2020, 59 (9), 3491-3494.
