1986-1991 上海医科大学药学院药物化学专业 本科
1993-1997 上海医科大学药学院药物化学专业 硕士
2003-2008 复旦大学药学院药物化学专业 博士
1991-1997 上海医科大学药学院 助教
1997-2000 上海医科大学药学院 讲师
2000-2009 复旦大学药学院 讲师
2009-至今 复旦大学药学院 副教授
2012-2019 复旦大学枫林校区建设部 部长
2013-2019 复旦大学枫林校区管委会 副主任
2020-2021 复旦大学基建处 副处长
2020-2021 复旦大学张江校区管委会 副主任
2021-至今 复旦大学枫林校区管委会 主任
2022.07-至今 九三学社上海市委员会 委员
1. 国家自然科学基金重点项目(No. 21937002, 2020/01–2024/12,子课题负责人)
2. 国家自然科学基金重点项目(82030113, 2021/01-2025/12 主要参与人)
3. 校企合作项目:多烯大环内脂类抗生素的开发研究(2021-2025)
3. 校企合作项目:多杀菌素微生物发酵探究,主持
4. 国家重大新药创制专项:新型抗感染药物的活性研究(2015-2016,子课题负责)
5. 科技部新药创制重大专项:2009ZX09301-011,抗乙肝病毒药物临床前研究,2009-2011,主持
6. 司法部合作项目,蛇毒蛋白的分离鉴定,2014,主持
7. 校企合作项目多项,到位横向经费500余万元
8. 国际合作项目:抗感染药物多利培南研究,2011-2012,主持
2005年获得上海市科学技术进步三等奖(排名第三)(上海市人民政府)
2005年获得上海药学科技进步奖二等奖(排名第三)(上海市药学会)
1. 微生物转化与微生物发酵的研究
2. 微生物次级代谢产物生物合成机制研究
3. 植物内生菌活性物质研究
4. 抗感染药物评价及抗感染天然活性物质研究
新药证书:
饲料添加剂那西肽原料药(三类):国家98新兽药第07号(农业部)
饲料添加剂那西肽预混剂(三类):国家98新兽药第06号(农业部)
1. 老鹳草总黄酮提取物及其在制备抗病毒药物中的用途。专利号:ZL 03 1 15358.5,2005
2. 一种制备人参皂甙CK的方法。专利号:ZL 2004 1 0018000.0
3. 由荷叶总黄酮提取物和田基黄总黄酮提取物组成的组合物在制备抗乙肝病毒药物中的用途。专利号:ZL 2007.1.0170416.8
4. 半枝莲总黄酮及其在制备抗流感病毒药物中的应用。专利号:200710047257.2
5.一株产制霉色基素的大别山五针松内生链霉菌及其制备方法。专利号:ZL 2020 10772722.4,2025
1、 Lu Gan, Zhengyu Zhang, Jingtao Chen, Zhichun Shen, Wujie Chen, Shaoxin Chen *and
Jiyang Li*. Enhancement ofspinosad production in Saccharopobyspora spinosa-byoverexpression ofthe complete74-kb spinosyn gene cluster. Microbial Cell Factories.2025,24:102
2、An anti-complement homogeneous polysaccharide from Houttuynia cordata ameliorates acute pneumonia with H1N1 and MRSA coinfection through rectifying Treg/Th17 imbalance in the gut–lung axis and NLRP3 inflammasome activation.Linxing Li, Wenxin Ding , Yan Lu, Haiyan Zhu, Weilian Bao, Yang Liu, Jiaren Lyu, Lishuang Zhou, Hong Li *, Jiyang Lib*, Daofeng Chen*.Acta harmaceutical Sinica B,2025,15(6):3073-3091
3、Xiao-Rui Liu, Ke-Xin Li, Hao-Wei Chen, Yu-Hang He, Hai-Yan Wang, Yi-Cheng Mao, Ji-Yang Li*, Jin-Feng Hu and Juan Xiong*, Bioactive polyketides and tryptophol alkaloids from the endophytic fungus Botryosphaeria dothidea LE-07 of Chinese tulip tree. Fitoterapia, 2024, 179: 106229.
4、Mengran Wang, flaowei Chen, L ihong Yan, Jingtao Chen, Lu Gan, Zhichun Shen,Juan Xiong, Jinfeng Hu, Jiyang Li* Solanapyrone analogues from endophyticMigrospora, sphaerica: MZW-A-associated with the endangered conifer Pinus wangii. Fitoterapia 2024,179:106275
5、Miyang Wan, Lu Gan, Zhenxin Li ,Mengran Wang, Jintao Chen, Shaoxin Chen, Jinfeng Hu, Jiyangli*.Enhancement of funguchromin production of Streptimayces sp.WP-1 by genetic engineering, Applied Microbiology and Biotechnology2023,107:5415-5425.
6、Mengran Wang, Kedan Gu,Miyang Wan , Ku Gan,Jintao Chen,Weili Zhao,Hang Shi,Jiyang Li*.Hydrogen pexoxide enhanced photoinactivation of candida albicans by de novel boron-dipyrromethene (BODIPY) derivative. Photochemical&Photobiological Sciences.2023,22:1695-1706
7、Wenxin Ding, Hao-Wei Chen, Mengran Wang, Miyang Wan, Jin-Feng Hu, Jiyang Li*.
Threenew eremophilane sesquiterpenes and one new related derivative from Nemania sp. HDF-Br-5, an endophytic fungus of the endangered conifer Pseudotsuga gaussenii Flous. Phytochemistry Letters. 2022, 49: 5-11.
8、Yuan-Xing Zhu, Wenxin Ding, Jin-Feng Hu, Juan Xiong * ,Jiyang Li*. Beshanzuamide A, an unprecedented prenylated indole alkaloid produced by the endophytic Aspergillus sp. Y-2 from the critically endangered conifer Abies beshanzuensi. RSC Advances .2022, 12(17):10534-10539
9、Miyang Wan, Cheng Peng, Wenxin Ding, Mengran Wang, Jinfeng Hu, Jiyang Li*. Calcium-
phosphate combination enhances spinosad production in Saccharopolyspora spinosa via regulation of fatty acid metabolism. Applied Biochemistry and Biotechnology. 2022, 196(6):2542-2564
10、Wei, T. Y., Zheng, Y., Wan, M., Yang, S., Tang, J., Wu, Y., Li, J., & Chen, S. X*. Analysis of FR901379 Biosynthetic Genes in Coleophoma empetri by Clustered Regularly Interspaced Short Palindromic Repeats/Cas9-Based Genomic Manipulation. ACS chemical biology, 2022, 17(8), 2130–2141.
11、Wang, M., Gu, K., Ding, W., Wan, M., Zhao, W., Shi, H., & Li, J. *. Antifungal effect of a new photosensitizer derived from BODIPY on Candida albicans biofilms. Photodiagnosis and photodynamic therapy, 2022, 39, 102946.
12、Guangyu Lin, Mei Hu, Rong Zhang, Yuanxing Zhu, Kedan Gu, Junping Bai, Jiyang Li*, Xiaochun Dong*, Weili Zhao*. Discovery of Meso-(meta-Pyridinium) BODIPY Photosensitizers: In Vitro and In Vivo Evaluations for Antimicrobial Photodynamic Therapy. J. Med. Chem., 2021, 64 (24): 18143-1815.
13、Hang Shi ,Jiyang Li*, Cheng Peng, Hongying Sun.The inhibitory activity of 5-aminolevulinic acid photodynamic therapy (ALA-PDT) on Candida albicans biofilms. Photodiagnosis and Photodynamic Therapy, 2021,4:102271.
14、Yuan-Xing Zhu, Cheng Peng, Shui Yu ,Jin-Feng Hu, Jiyang Li*. Aflatoxins from the endophytic fungus Aspergillus sp. Y-2 isolated from the critically endangered conifer Abies beshanzuensi. Natural Product Research, 2021, 35: 3248-3253.
15、Shui Yu, Yuan-Xing Zhu, Cheng Peng, Jiyang Li*Two new sterol derivatives isolated from the endophytic fungus Aspergillus tubingensis YP-2. Natural Product Research, 2021, 35: 3277-3284.
16、 Cheng Peng, Duopeng An, WenXin Ding, Yuan-Xing Zhu, Li Ye, Jiyang Li*. Fungichromin
production of Streptomyces sp. WP-1, an endophyte from Pinus dabeshanensis, and its antifungal activity against Fusarium oxysporum. Applied Microbiology and Biotechnology, 2020, 104: 10437–10449.
17、 Yuan-Xing Zhu, Cheng Peng, Wenxin Ding, Jin-Feng Hu, Jiyang Li*. Chromenopyridin A,
a new N-methoxy-1-pyridone Alkaloid from the endophytic fungus Penicillium nothofagi P-6 isolated from the critically endangered conifer Abies beshanzuensi. Natural Product Research, 2020, 2: 1-7.
18、 Kedan Gu, Guangyu Lin, Yuanxing Zhu, Xin Ji, Jiyang Li*, Xiaochun Dong*, Weili Zhao*. Anchoring BODIPY photosensitizers enable pan-microbial photo-inactivation. Eur. J Med. Chem.,2020, 199: 112361