2008.9-2012.6 兰州大学本科
2012.9-2015.6 中山大学硕士
2015.9-2018.6 复旦大学博士
2018.9-2021.4 美国国立卫生研究院博士后
2021.5-至今 复旦大学药学院青年副研究员
1.国家自然科学基金面上项目:SNX10调控溶酶体酸性脂肪酶活性在巨噬细胞极化及动脉粥样硬化中的作用(No. 81573441),2016.1-2019.12,65万,第一完成人。
2. 国家自然科学基金面上项目:靶向干预肠上皮细胞分选连接蛋白10对炎症性肠病的影响及分子机制(No. 81773744),2018.01-2021.12,59.5万,4/7。
3. 国家自然科学基金面上项目:SNX10调控RANKL/RANK/OPG信号轴在内皮细胞介导的糖尿病血管钙化中的作用及机制研究(No. 82073859),2021.01-2024.12,55万,3/6。
4. NIAID grant: Identification of co-receptor and components involved in the entry of SARS-CoV-2 using quantitative phosphoproteomic approach, 2020.6-2021.9, 65万(美元),2/3.
1. 上海市药学会第七届药理学青年论文报告会 优秀论文二等奖 2018
2. 上海市药学会第五届药理学青年论文报告会 优秀论文二等奖 2016
1、代谢免疫性疾病的病理机制与关键靶点发现;
2、内体/溶酶体途径的信号调控;
3、靶向药物筛选及分子药理机制研究。
申请专利
沈晓燕, 游艳, 李海东. SNX10在制备作为预防和/或治疗心血管疾病的药物靶点中的应用, CN201810626676.X.
1. You Y, Bao WL, Zhang S, et al. Sorting Nexin 10 Mediates Metabolic Reprogramming of Macrophages in Atherosclerosis Through the Lyn-dependent TFEB Signaling Pathway. Circ Res, 2020;127:534–549. (IF=17.6)
2. Bao W*, Liu X*, You Y*, et al. Targeting sorting nexin 10 improves mouse colitis via inhibiting PIKfyve-mediated TBK1/c-Rel signaling activation. Pharmacol Res. 2021 May 16; 169:105679. (IF=5.892)
3. You Y and Sharmila GR. A crisper-based method for testing the essentiality of a gene. Sci Rep. 2020 Sep 8;10(1):14779. (IF=4.3)
4. Fan YJ, Yang JL and You Y#. SNX10 deficiency restricts foam cell formation and protects against atherosclerosis by suppressing CD36-Lyn axis. CJC, 2020 May 16; S0828-282X(20)30456-6. 通讯作者(IF=5)
5. You Y, Li WZ, Zhang S, et al. SNX10 mediates alcohol-induced liver injury and steatosis by regulating the activation of chaperone-mediated autophagy. J Hepatol. Jul 2018;69(1):129-141. (IF=25.03)
6. You Y, Zhou C, Li D, et al. Sorting nexin 10 acting as a novel regulator of macrophage polarization mediates inflammatory response in experimental mouse colitis. Sci Rep. 2016; 6: 20630. (IF=3.997)
7. Zhou C, You Y, Zhu YZ, et al. Deficiency of sorting nexin 10 prevents bone erosion in collagen induced mouse arthritis through promoting NFATc1 degradation. Ann Rheum Dis. 2016; 75:1211-8. (IF=16)