冯美卿
生物药物学, 教授, 博士生导师

姓      名

 冯美卿

性      别

 女

职      称

 教授

学      历

 博士

电      话

 021-51980035

传      真

 

电子邮件

 fmq@fudan.edu.cn

个人主页

 

通讯地址

 张衡路826号科研楼225

 

教育经历
1985.08 – 1990.07 上海医科大学药学院学士

1996.03 – 1999.03 石油大学(北京)化学工艺系硕士

2001.09 – 2004.06 复旦大学药学院博士


工作经历
1990.07 – 1994.06 河北省药物研究所试验药厂

1994.07 – 2004.11 河北科技大学,化学与制药工程学院

2004.12 – 2014.12 复旦大学药学院,副教授

2014.12 – 现在      复旦大学药学院,教授


承担科研项目情况
1. 上海市科委重点项目:抗癌药物CK-和蛋白激酶用于肝癌诊断中的子课题微生物转化法制备抗癌药物CK,(054319927)子课题负责人, 2005-2007

2. 国家自然基金项目:人参稀有皂甙微生物转化机制(途径)及代谢调节(30772676)2008-2010

3. 国家自然基金项目:重组HDL-药物复合物肝靶向性及其分子机制研究(30973684)2010年-2012年,

4. 国家自然基金项目:载脂蛋白AI介导小干扰RNA靶向至肝脏的相关机制及抗HBV作用研究(81341083)

 2014-2015

5. 上海市纳米专项课题载脂蛋白A-I介导的重组HDL纳米粒肝靶向性及其机制研究(0952nm03500),

 2009-2011。

6. 上海市科委重点项目毕赤酵母表达人载脂蛋白A-I抗动脉粥样硬化成药性研究(12431900202)

  2012-2015

7. 973项目肺癌在体分子分型的新型纳米分子成像探针基础研究(骨干(2015CB931800) 2015-2019


获奖及荣誉
上海市科委科技进步     二等奖  排名第二

上海市药学会科技进步  三等奖  排名第二


研究方向
1. 基因工程技术药物研发及应用

2. 天然产物为生物转化研究


社会任职
2010.05 – 现在  上海药学会抗生素分会理事
代表性论著
1. Mei-qing Feng, Qin-sheng Cai, Da-xin Song, Ji-bin Dong, Pei Zhou High yield and secretion of recombinant human apolipoprotein  AI in Pichia pastoris Protein Expression and PuriWcation. 2006; 46: 337–342

2. Meiqing Feng, QinshengCai, Hai Huang, Pei Zhou *. Liver targeting and anti- HBV activity of reconstituted HDL–acyclovir palmitate complex. European Journal of Pharmaceutics and Biopharmaceutics. 2008; 68: 688–693

3. Meiqing Feng, QinshengCai, Pei Zhou, Xin Guo. Recombinant high-density lipoprotein complex as a targeting system of nosiheptide to liver cells. Journal of Drug Targeting. 2008; 16(6): 502–508

4. Meiqing Feng, QinshengCai, Hai Huang, Pei Zhou. Liver targeting and anti-HBV activity of reconstituted HDL–acyclovir palmitate complex. European Journal of Pharmaceutics and Biopharmaceutics. 2008; 68: 688–693

5. Wei Zhou, Meiqing Feng, (共同第一) Xinwei Li, Qin Yan, Chaoqun Zhou, Jiyang, Lian Pei Zhou. X-Ray Structure Investigation of Glucopyranosyl- protopanaxadiol and Antitumor Effect on Lewis Lung Carcinoma in vivo. Chemistry & Biodiversity. 2009; 6: 380-388

6. Li Ye, Chao-Qun Zhou, Wei Zhou, Pei Zhou, Dao-Feng Chen, Xiao-Hui Liu, Xun-Long Shi , Mei-Qing Feng*;Biotransformation of ginsenoside Rb1 to ginsenoside Rd by highly substrate tolerant Paecilomycesbainier 229-7. Bioresource Technology. 2010; 101: 7872–7876

7. Qin Yan, Wei Zhou, XunLong Shi, Pei Zhou, DianWenJu, MeiQing Feng*. Biotransformation pathways of ginsenoside Rb1 to compound K by_-glucosidases in fungus PaecilomycesBainier sp. 229. Process Biochemistry. 2010; 45: 1550–1556

8. Yang Ding, Wei Wang,* Meiqing Feng, Jianping Zhou,* A biomimetic nanovector -mediated targeted cholesterol-conjugated siRNA delivery for tumor gene therapy. Biomaterials. 2012 (33): 8893-8905

9. Li Ye, Chunyan Zhang, Jiyang Li, Xunlong Shi &Meiqing Feng *.Effects of external calcium on the biotransformation of ginsenoside Rb1 to ginsenoside Rd by Paecilomycesbainier 229-7. World J MicrobiolBiotechnol. 2012 (28): 857–863

10. Yuan Yuan, Weina Wang, Baolong Wang, Haiyan Zhu, Boheng Zhang, and Meiqing Feng. Delivery of hydrophilic drug doxorubicin hydrochloride targeted liver using apoAI as carrier.  Journal of  Drug of Targeting. 2013.21(4): 367–374

11. Weina Wang, Xunlong Shi, Yuan Yuan, Haiyan Zhu, Wei Zhou, Hai Huang, and Meiqing Feng*.  Inhibitory effect of apolipoprotein A-I on matrix metalloproteinase-2 expression in vivo and in vitro ActaBiochimBiophys Sin. 2013; 45: 194–202

12. Weina Wang, Wei Zhou, Baolong Wang, Haiyan Zhu, Meiqing Feng*.Antioxidant effect of apolipoprotein A-I on high-fat diet-induced non-alcoholic fatty liver disease in rabbits ActaBiochimica et BiophysicaSinica. 2013; 45: 95–103

13. Baolong Wan ,Yuan Yuan, Lei Han, and Meiqing Feng Recombinant lipoproteins reinforce cytotoxicity of doxorubicin to hepatocellular carcinoma. J Drug Target, 2014; 22(1): 76–85

14. Jiajun Fan, Xian Zeng, Yubin Li, Shaofei Wang, Ziyu Wang, Yun Sun, MeiqingFeng*, DianwenJu* Autophagy Plays a Critical Role in ChLym-1-Induced Cytotoxicity of Non-Hodgkin’s Lymphoma Cells. Plos One  doi:10.1371/journal.pone.0072478

15. Li Ye, Jiajun Fan, et al, Meiqing Feng*,  DianwenJu*  Tumor Necrosis Therapy Antibody Interleukin-2 Fusion Protein Elicits Prolonged and Targeted Antitumor Effects in vivo. ApplMicrobiolBiotechnol. 2014; 98:4053–4061

16. Meiqing Feng, Ziwei Liao, Lei Han, Jiyang Li & Li Ye. Enhancement of microbial hydroxylation of 13-ethyl-gon-4-ene-3,17-dione by Metarhiziumanisopliae using anoliposome technique. Journal of Industrial Microbiology &Biotechnology. 2014; 41:619-627 

17. Wang baolongHanleiet al, Feng meiqing*  Combination of ApoA1 Modified  Liposome-doxorubicin with Autophagy Inhibitors Overcame Drug resistance in Vitro Pharmaceutical Sciences  103:3994–4004, 2014

18. Zhu HaiYan, Han Lei et al, Feng Meiqing*  Baicalin Inhibits Autophagy Induced by Influenza A Virus H3N2. Antiviral Research. 2015; 113: 62-70


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