章旭耀

生物药物学, 青年研究员, 硕士生导师

姓名	章旭耀	性别	男
职称	青年研究员	学历	博士
电话	021-51980129	传真	021-51980035
电子邮件	xuyaozhang@fudan.edu.cn	个人主页	https://www.researchgate.net/profile/Xuyao_Zhang
通讯地址	上海市张衡路826号复旦大学药学院

教育经历

2015.9 – 2018.7复旦大学药学院博士

2012.9 – 2015.7郑州大学药学院硕士

2008.9 – 2012.7郑州大学药学院本科

工作经历

2020.9 – 至今复旦大学生物药物学系青年研究员

2018.7 – 2020.8宾夕法尼亚大学肿瘤生物学博士后

承担科研项目情况

复旦大学引进人才科研基金（2020-2023，主持）

获奖及荣誉

2018 上海市普通高等学校优秀毕业生

European Society for Medical Oncology (ESMO) Immuno Oncology Congress 2017. Poster Discussion & Travel Award

2017 宝钢教育奖学金特等奖

2017 Japanese Society of Medical Oncology (JSMO) Annual Meeting. Oral Presentation & Travel Award

European Society for Medical Oncology (ESMO) Asia 2016 Congress. Poster Presentation & Travel Award

2016 Japanese Society of Medical Oncology (JSMO) Annual Meeting. Oral Presentation & Travel Award

2015 河南省普通高等学校优秀毕业生

2014 研究生国家奖学金

研究方向

新型免疫治疗生物技术药物的研究与开发

代表性论著

1. Zhang X, Wang Y, Fan J, Chen W, Luan J, Mei X, Wang S, Li Y, Ye L,Li S, Tian W, Yin K*, Ju D*. Blocking CD47 efficiently potentiated therapeuticeffects of anti-angiogenic therapy in non-small cell lung cancer. Journal forImmunoTherapy of Cancer. 2019; 7:346.

2. Zhang X, Fan J, Ju D*. Insights into CD47/SIRPα axis-targetingtumor immunotherapy. Antibody Therapeutics. 2018; 1:37-42.

3. Zhang X, Chen W, Fan J, Wang S, Xian Z, Luan J, Li Y, Wang Y, NanY, Luo M, Li S, Tian W, Ju D*. Disrupting CD47-SIRPα axis alone or combinedwith autophagy depletion for the therapy of glioblastoma. Carcinogenesis. 2018;39:689-699.

4. Zhang X, Wang S, Nan Y, Fan J, Chen W, Luan J, Wang Y, Liang Y, LiS, Tian W, Ju D*. Inhibition of autophagy potentiated the anti-tumor effects ofVEGF and CD47 bispecific therapy in glioblastoma. Applied Microbiology and Biotechnology.2018; 102:6503-6513.

5. Zhang X, Luan J, Chen W, Fan J, Nan Y, Wang Y, Liang Y, Meng G, JuD*. Mesoporous silica nanoparticles induced hepatotoxicity via NLRP3inflammasome activation and caspase-1-dependent pyroptosis. Nanoscale. 2018;10:9141-9152.

6. Zhang X, Fan J, Wang S, Li Y, Wang Y, Li S, Luan J, Wang Z, Song P,Chen Q, Tian W, Ju D*. Targeting CD47 and autophagy elicited enhancedanti-tumor effects in non-small cell lung cancer. Cancer Immunology Research.2017; 5:363-375. (Spotlight Research)

7. Zhang X, Gu Y, Chen T, Yang D, Wang X, Jiang B, Shao K, Zhao W,Wang C, Wang J, Zhang Q, Liu H*. Synthesis, in vitro and in vivo anticanceractivities of novel 4-substituted 1,2-bis(4-chlorophenyl)-pyrazolidine-3,5-dione derivatives. MedChemComm. 2015, 6:1781-1786.

8. Luan J, Zhang X, Wang S, Li Y, Fan J, Chen W,Zai W, Wang S, Wang Y, Chen M, Meng G, Ju D*. NOD-Like Receptor Protein 3Inflammasome-Dependent IL-1β Accelerated ConA-Induced Hepatitis. Frontiers inImmunology. 2018; 9:758.

9. Chen W, Zhang X, Fan J, Zai W, Luan J, Li Y,Wang S, Chen Q, Wang Y, Liang Y, Ju D*. Tethering interleukin-22 toapolipoprotein A-I ameliorates mice from acetaminophen-induced liver injury.Theranostics. 2017; 7:4135-4148.