姓 名 | 王洋 | 性 别 | 女 |
职 称 | 教授 | 学 历 | 博士 |
电 话 | 021-51980115 | 传 真 | |
电子邮件 | wangyang@shmu.edu.cn | 个人主页 | |
通讯地址 | 上海市浦东新区张衡路826号复旦大学药学院 | ||
1989.09 – 1992.06 郑州大学化学系有机化学专业，硕士
2001.09 – 2005.06 复旦大学药学院药物化学专业，在职博士，获理学博士学位
1993.09 – 1994.09 日本京都龍谷大学，访问学者
1999.04 – 现在 复旦大学药学院药物化学教研室，副教授（2000年）、教授（2010年）
2006.01 – 现在 兼任药学实验教学中心主任
2015年 “宝钢优秀教师奖”
2013年 上海市教学成果二等奖（第二完成人）
2012年 复旦大学“创先争优·教书育人”优秀共产党员称号
代表性论著
2. Tang, H.; Liang, Y.; Cheng, J.; Ding, K.*; Wang, Y.* Bifunctional Chiral Selenium-Containing 1,4-Diarylazetidin-2-ones with Potent Antitumor Activities by Disrupting Tubulin Polymerization and Inducing Reactive Oxygen Species Production, Eur. J. Med. Chem. 2021, 221, 113531.
3. Lin, S.; Liang, Y.; Cheng, J.; Pan, F.; Wang, Y.* Novel Diaryl-2H-azirines: Antitumor Hybrids for Dual-targeting Tubulin and DNA, Eur. J. Med. Chem. 2021, 214, 113256.
4. Hao, E.-J.; Li, G.-X.; Liang, Y.-R.; Xie, M.-S.; Wang, D.-C.; Jiang, X.-H.; Cheng, J.-Y.; Shi, Z.-X.; Wang, Y.*; Guo, H.-M.* Design, Synthesis and Activity Evaluation of Novel Acyclic Nucleosides as Potential Anticancer Agents in Vitro and in Vivo, J. Med. Chem.2021, 64, 2077-2109.
5. Tang, H.; Cheng, J.; Liang, Y.; Wang, Y.* Discovery of a Chiral Fluorinated Azetidin-2-one as a Tubulin Polymerisation Inhibitor with Potent Antitumour Efficacy, Eur. J. Med. Chem. 2020, 197, 112323.
6. Liu, M.; Liang, Y.; Zhu, Z.; Wang, J.; Cheng, X.; Cheng, J.; Xu, B.; Li, R.; Liu, X.*; Wang, Y.* Discovery of Novel Aryl Carboxamide Derivatives as Hypoxia-Inducible Factor (HIF) 1α Signaling Inhibitors with Potent Activities of Anticancer Metastasis, J. Med. Chem. 2019, 62, 9299-9314.
7. Gao, F.; Liang, Y.; Zhou, P.; Cheng, J.; Ding, K.*; Wang, Y.* Design, Synthesis, Antitumor Activities and Biological Studies of Novel Diaryl Substituted Fused Heterocycles as Dual Ligands Targeting Tubulin and Katanin, Eur. J. Med. Chem.2019, 178, 177-194.
8. Zhou, P.; Liang, Y.; Zhang, H.; Jiang, H.; Feng, K.; Xu, P.; Wang, J.; Wang, X.; Ding, K.*; Luo, C.*; Liu, M.*; Wang, Y.*Design, Synthesis, Biological Evaluation and Cocrystal Structures with Tubulin of Chiral β-Lactam Bridged Combretastatin A-4 Analogues as Potent Antitumor Agents, Eur. J. Med. Chem. 2018, 144, 817-842.
9. Zhang M.; Liang, Y.-R.; Li, H.; Liu, M.-M.*; Wang, Y.* Design, Synthesis, and Biological Evaluation of Hydantoin Bridged Analogues of Combretastatin A-4 as Potential Anticancer Agents, Bioorg. Med. Chem. 2017, 25, 6623-6634.
10. Sheng, X.; Jia, X.-Y.; Tang, F.; Wang, Y.*; Hou, A.-J.* The Total Synthesis of (±)-Sanggenol F, Tetrahedron 2017, 73, 3485-3491.
11. Zhou, P.; Liu, Y.; Zhou, L.; Zhu, K.; Feng, K.; Zhang, H.; Liang, Y.; Jiang, H.; Luo, C.*; Liu, M.*; Wang, Y.* Potent Anti-tumor Activities and Structure Basis of the Chiral β-Lactam Bridged Analogue of Combretastatin A-4 Binding to Tubulin, J. Med. Chem.2016, 59, 10329-10334.
