姓 名 | 邵黎明 | 性 别 | 男 |
职 称 | 教授 | 学 历 | 博士 |
电 话 | 021-51980201 | 传 真 | 021-51980017 |
电子邮件 | limingshao@fudan.edu.cn | 个人主页 | |
通讯地址 | 上海市浦东新区张衡路826号科研楼裙西108室 | ||
教育经历
1978.09 – 1982.07 复旦大学化学系, 有机化学专业，理学学士
1987.09 – 1990.03 日本东京大学工学部, 工业化学专业，工学硕士
1990.03 – 1993.03 日本东京大学工学部, 工业化学专业，工学博士
1993.04 – 1996.08 哈佛大学, 化学和化学生物系, 博士后研究员
工作经历
1982.08 – 1987.05 世界卫生组织人类生殖研究中心/上海计划生育研究所, 药物研究室，助理研究员
1998.09 – 2010.10 Sepracor公司, 药物研发及临床前研究部 (美国, 马萨诸塞州)
2008-2010 资深总监
2005-2008 总监
2001-2005 副总监
2000-2001 资深科学家
1998-2000 科学家
2010.10 – 2012.05 Sunovion公司, 临床前研究及转化医学部 (美国, 马萨诸塞州)资深总监
2012.06 –至今复旦大学药学院，教授
专家类别
教授
职务
博士生导师、上海市药物研发协同创新中心主任、复旦大学医药健康产业发展战略研究中心主任
主要科研贡献
参与和主持了各类药物的研究与开发工作，其中4个化合物获美国FDA认准进入临床试验，曾参与避孕药的研发，其中一个药物获得中国FDA批准上市
研究方向
1. 中枢神经系统疾病诊断治疗药物的合理设计、合成与研究开发
2. 恶性肿瘤治疗药物的研究开发
3. 药物发现新方法（合成新方法、成药性、结构生物学）的研究开发
4. 药物研究中转化医学手段的探索研究
1. Kong, L.H.; Ning, K.; Liu, X.; Lu, J.S.; Chen, B.Y.; Ye, R.R.; Li, Z.X.; Jiang, S.; Tang, S.Y.; Chai, J.R.; Fang, Y.; Lan, Y.J.; Mai, X.B.; Xie, Q.; Liu, J.G.*; Shao, L.M.*; Fu, W.; Wang, Y.J.*; Li, W.* Reversal of Subtype-Selectivity and Function by the Introduction of a Para-Benzamidyl Substituent to N-cyclopropylmethyl Nornepenthone. Eur J Med Chem, 2023, Oct 5;258:115589.
2. Ouyang, X.S.; Su, M.; Xue, D.Q.; Dong, L.Y.; Niu, H.L.; Li, W.*; Liu, Y.N.*; Wang, K.W.*; Shao, L.M*. Design, synthesis, and biological evaluation of acyl sulfonamide derivatives with spiro cycles as NaV1.7 inhibitors for antinociception. Bioorg Med Chem, 2023, 86, 117290.
3. Kong, L. H.; He, Q.; Li, Q.; Schreiber, R.; Kaitin, K. I.; Shao, L. M.* Rapid progress in neuroimaging technologies fuels central nervous system translational medicine. Drug Discov Today 2023 Mar; 28(3):103485.
4. Tang, S. Y.; Xue, Y. J.; Dengqi, X.; Shao, L. M.* Design, development and evaluation of a prodrug-type TrkA-selective inhibitor with antinociceptive effects in vivo. Eur J Med Chem 2023 Jan 5;245(Pt 2):114901.
5. Liang, Q.Q.; Qiao, Z.; Zhou, Q.Q.; Xue, D.Q.; Wang, K.W.; Shao, L.M.* Discovery of Potent and Selective Transient Receptor Potential Vanilloid 1 (TRPV1) Agonists with Analgesic Effects In Vivo Based on the Functional Conversion Induced by Altering the Orientation of the Indazole Core. J Med Chem 2022, 65, 11658-11678.
6. Kong, L. H.; Shu, X. L.; Tang, S. Y.; Ye, R. R.; Sun, H. J.; Jiang, S.; Li, Z. X.; Chai, J. R.; Fang, Y.; Lan, Y. J.; Yu, L. Q.; Xie, Q.; Fu, W.; Wang, Y. J.*; Li, W.*; Qiu, Z. B.; Liu, J. G.*; Shao, L. M.* SLL-627 Is a Highly Selective and Potent Kappa Opioid Receptor (KOR) Agonist with an Unexpected Nonreduction in Locomotor Activity. J Med Chem 2022, 65, 10377-10392.
7. Qiao, Z.; Tang, S. Y.; Guan, J. L.; Yin, Z. J.; Zhu, C.; Zhou, Q. Q.; Shao, L. M.* Design and development of selective competitive fluorescent ligands for the detection and visualization of Kv7.2/7.3 in vitro. Chem Commun 2022, 58, 3791-3794.
8. Wei, Y. Y.; Ma, Y.; Yao, S. Y.; Kong, L. H.; Liu, X.; Chai, J. R.; Chen, J.; Li, W.*; Wang, Y. J.*; Shao, L. M.*; Liu, J. G.* Novel selective kappa agonists SLL-039 and SLL-1206 produce potent antinociception with fewer sedation and aversion. Acta Pharmacol Sin 2022, 43, 1372-1382.
9. Xue, D. Q.; Liu, Y. N.*; Zheng, Y. L.; Niu, H. L.; Dong, L. Y.; Ouyang, X. S.; Song, S. Y.; Zhang, D. G.; Ge, Q. W.; Wang, K. W.; Shao, L. M.* Design and synthesis of novel alpha-aminoamides derivatives as Nav1.7 inhibitors for antinociception. Chinese Chem Lett 2022, 33, 1643-1646.
10. Liang, Q. Q.; Cheng, H.; Li, C. W.; Ning, L. M.*; Shao, L. M.* A covalent modification strategy for di-alkyne tagged metal-organic frameworks to access efficient heterogeneous catalysts toward C-C bond formation. New J Chem 2022, 46, 1210-1221.
11. Xue, D. Q.; Liu, R. Q.; Zhang, D. G.; Li, N.; Xue, Y. J.; Ge, Q. W.; Shao, L. M.* Iron-catalyzed radical cascade cyclization of oxime esters with isocyanides: synthesis of 1-cyanoalkyl isoquinolines and 6-cyanoalkyl phenanthridines. Org Biomol Chem 2021, 19, 8597-8606.
12. Chen, H.; N., L.M.; Liao, S. Y.*; Li, W.; Tang, S. Y.; Li, J. L.; Chen, H. X.; Liu, X.; Shao, L. M.* Nickel- alkyne-functionalized metal-organic frameworks: An efficient and reusable catalyst. Appl Catal A - Gen 2021, 623, 118216.
13. Liu, X.; Jiang, S.; Kong, L. H.; Ye, R. R.; Xiao, L.; Xu, X. J.; He, Q.; Wei, Y. Y.; Li, Z. X.; Sun, H. J.; Xie, Q.; Xu, X.; Lu, Y.; Wang, Y. J.*; Li, W.*; Fu, W.; Qiu, Z. B.; Liu, J. G.*; Shao, L. M.* Exploration of the SAR Connection between Morphinan- and Arylacetamide-Based kappa Opioid Receptor (kappa OR) Agonists Using the Strategy of Bridging. Acs Chem Neurosci 2021, 12, 1018-1030.
14. He, Q.; Wei, Y.; Liu, X.; Ye, R.; Kong, L.; Li, Z.; Jiang, S.; Yu, L.; Chai, J.; Xie, Q.; Fu, W.; Wang, Y.J.*; Li, W.*; Qiu, Z.; Liu, J.G.*; Shao, L.M.* Discovery of an M-Substituted N-Cyclopropylmethyl-7alpha-phenyl-6,14-endoethanotetrahydronorthebaine as a Selective, Potent, and Orally Active kappa-Opioid Receptor Agonist with an Improved Central Nervous System Safety Profile. J Med Chem 2021, 64, 12414-12433.
15. Niu, H. L.; Liu, Y. N.*; Xue, D. Q.; Dong, L. Y.; Liu, H. J.; Wang, J.; Zheng, Y. L.; Zou, A. R.; Shao, L. M.*; Wang, K. W.* Inhibition of Nav1.7 channel by a novel blocker QLS-81 for alleviation of neuropathic pain. Acta Pharmacol Sin 2021, 42, 1235–1247.
16. Xue, Y. J.; Xue, D. Q.; He, Q.; Ge, Q. W.; Li, W.; Shao, L. M.* Additive-Free Radical Cascade Reaction of Oxime Esters: Synthesis of Pyrroline-Functionalized Phenanthridines. J Org Chem 2020, 85, 12284-12293.
17. Zheng, Y. L.; Xiao, L.; Xie, Q.; Shao, L. M.* Palladium-Catalyzed Synthesis of beta,beta-Diaryl alpha,beta-Unsaturated Ketones. Synthesis-Stuttgart 2019, 51, 1455-1465.
18. Xue, D. Q.; Xue, Y. J.; Yu, H. H.; Shao, L. M.* Metal-Free Radical Cyclization of Vinyl Isocyanides with Alkanes: Synthesis of 1-Alkylisoquinolines. Synthesis-Stuttgart 2019, 51, 874-884.
19. Xiao, L.; Wang, Y.J.; Zhang, M.M.; Wu, W.; Kong, L.; Ma, Y.; Xu, X.; Liu, X.; He, Q.; Qian, Y.; Sun, H.; Wu, H.; Lin, C.; Huang, H.; Ye, R.; Jiang, S.; Ye, R. F.; Yuan, C.; Fang, S.; Xue, D.; Yang, X.; Chen, H.; Zheng, Y.; Yu, L.; Xie, Q.; Zheng, L.; Fu, W.; Li, W.*; Qiu, Z.B.; Liu, J.G.*; Shao, L.M.* Discovery of a Highly Selective and Potent kappa Opioid Receptor Agonist from N-Cyclopropylmethyl-7alpha-phenyl-6,14-endoethanotetrahydronorthebaines with Reduced Central Nervous System (CNS) Side Effects Navigated by the Message-Address Concept. J Med Chem 2019, 62, 11054-11070.
20. Fang, S. Y.; Yu, H. H.; Yang, X. C.; Li, J. Q.; Shao, L. M.* Nickel-Catalyzed Construction of 2,4-Disubstituted Imidazoles via C-C Coupling and C-N Condensation Cascade Reactions. Adv Synth Catal 2019, 361, 3312-3317.
21. Yang, X. C.; Shen, J.; Jiang, L. L.; Li, W.; Yu, M. C.; Pan, G. X.; Yan, Y. R.; Zhang, C. H.; Jia, W. W.; Xiao, L.; Yu, H. H.; Chen, H.; Zheng, Y. L.; Yu, L. Q.; Xie, Q.; Zhou, L.; Shao, L. M.* Discovery, cocrystallization and biological evaluation of novel piperidine derivatives as high affinity Ls-AChBP ligands possessing alpha 7 nAChR activities. Eur J Med Chem 2018, 160, 37-48.
22. Yang, X.; Yu, H.; Xu, Y.; Shao, L.M.* Regioselective Access to 3-Aryl-1-aminoisoquinolines via Nickel(I)-Catalyzed C-C and C-N Cascade Coupling Reactions from the Substituted 2-(Cyanomethyl)benzonitriles. J Org Chem 2018, 83, 9682-9695.
23. Xu, Y. L.; Yang, X. C.; Chen, Y. Y.; Chen, H.; Sun, H. J.; Li, W.; Xie, Q.; Yu, L. Q.; Shao, L. M.* Discovery of novel 20S proteasome inhibitors by rational topology-based scaffold hopping of bortezomib. Bioorg Med Chem Lett 2018, 28, 2148-2152.
24. Xu, Y. L.; Chen, H.; Li, W.; Xie, Q.; Yu, L. Q.; Shao, L. M.* Synthetic access to isoxazoline-functionalized isoquinolines via microwave-assisted iminoxyl radical-participated cascade cyclization of vinyl isocyanides. Org Biomol Chem 2018, 16, 4996-5005.
25. Sun, H. J.; Wang, Y. H.; Yuan, C. M.; Kong, L. H.; Xu, X. J.; Wang, Y. J.; Wu, H. H.; Lin, C.; Qian, Y. Y.; Huang, H. M.; Xiao, L.; Liu, X.; He, Q.; Fang, S. Y.; Xue, D. Q.; Yang, X. C.; Chen, H.; Zheng, Y. L.; Zheng, L.; Yu, L. Q.; Xie, Q.; Fu, W.; Li, W.; Liu, J. G.; Qiu, Z. B.; Shao, L. M.* 7 beta-Methyl substituent is a structural locus associated with activity cliff for nepenthone analogues. Bioorg Med Chem 2018, 26, 4254-4263.
