丁宁

药物化学, 教授, 博士生导师

发布时间:2021-05-10浏览次数:9783

姓      名

 丁宁

性      别

 男

职      称

 教授

学      历

 博士

电      话

 021-51980120

传      真

 

电子邮件

 dingning@fudan.edu.cn

个人主页

 

通讯地址

 上海市张衡路826号复旦大学张江校区实验南楼405室

 

教育经历

2004 – 2007,中国海洋大学医药学院,教育部海洋药物重点实验室,博士

2001 – 2004,中国海洋大学医药学院,教育部海洋药物重点实验室,硕士

1997 – 2001,中国海洋大学水产学院,药物化学专业,学士


工作经历

2022 –  今, 复旦大学药学院药物化学系,教授,博士生导师

2013 – 2021,  复旦大学药学院药物化学系,副教授

(其中:2014 – 2016,佐治亚大学复杂碳水化合物研究中心,访问学者)

2009 – 2012,复旦大学药学院药物化学系,讲师

2007 – 2008,普度大学化学系,博士后


主持科研项目情况

1. 国家自然科学基金面上项目。

2. 新药创制重大专项。

3. 上海市科委“科技创新行动计划”生物医药领域科技支撑项目。

4. 上海市人才发展资金。

5. 国家自然科学基金青年项目。

6. 中科院上海药物所新药研究国家重点实验室开放课题。

7. 教育部留学回国人员科研启动基金。

8. 教育部博士点新教师基金。

9. 复旦大学新教师科研启动基金。

10.企业横向课题。


获奖及荣誉

2018年 复旦大学德传奖教金

2017年 上海市人才发展资金(上海市人力资源与社会保障局)

2013年 复旦大学第一三共制药奖教金

2013年 复旦大学青年教师讲课比赛(医科组)二等奖

2012年 复旦大学优秀青年人才项目“卓学计划”(2012-2014)。

2012年 复旦大学药学院青年教师讲课比赛一等奖。


研究方向

糖类药物与海洋药物


成果

丁宁博士为上海市人社局人才发展资金获得者。课题组的主要研究兴趣为糖类药物与海洋药物。发表SCI收录学术论文60余篇。研究工作获国家新药创制重大专项、国家自然科学基金、上海市生物医药专项等十余项国家、省部级课题的资助。主讲本科生课程《药物化学》(上海市精品课程/上海市教委本科重点课程/复旦大学精品课程)、《化学生物学导论》部分章节并带教《有机化学实验》等;主讲研究生课程《糖化学》及《高等药物化学》部分章节等。


近期代表性论著

1. Yu-Long He, Meng-Ting Chen, Ting Wang, Ming-Ming Zhang, Ying-Xia Li*, He-Yao Wang*, Ning Ding*. Development of FABP4/5 inhibitors with potential therapeutic effect on type 2 diabetes mellitus. European Journal of Medicinal Chemistry, 2021, 224, 11370 (https://doi.org/10.1016/j.ejmech.2021.113720).

2. Sumei Ren, Minmin Zhang, Yujie Wang, Jia Guo, Junfei Wang, Yingxia Li, Ning Ding*. Synthesis and biological evaluation of novel Cabazitaxel analogues. Bioorganic & Medicinal Chemistry, 2021, 41, 116224 (https://doi.org/10.1016/j.bmc.2021.116224).

3. Lei Li, Haisheng He, Sifang Jiang, Jianping Qi, Yi Lu, Hai-shu Lin,Ning Ding, Wei Wu*, Xiaoqiang Xiang*. Simulation of the in vivo fate of polymeric nanoparticles traced by environment-responsive near-infrared dye: A physiologically based pharmacokinetic modelling approach. Molecules, 2021, 26, 1271 (https://doi.org/10.3390/molecules26051271) .

4. Yang Zhang, Jia Guo, Xiaoyan Xu, Qi Gao, Xianglai Liu, and Ning Ding*. A practical and scalable synthesis of KRN7000 by using of glycosyl iodide as the glycosyl donor. Journal of Chemical Research, 2021, 248-252 (https://doi.org/10.1177/1747519820961018).

5. Ke Xu#, Qingmin Man#, Yang Zhang, Jia Guo, Yichu Liu, Zunyun Fu, Yueyue Zhu, Yingxia Li, Mingyue Zheng*, Ning Ding*. Investigation of the remote acyl group participation in glycosylation from conformational perspectives by using trichloroacetimidate as the acetyl surrogate. Organic Chemistry Frontiers, 2020,7, 1606-1615 (DOI: 10.1039/d0qo00363h).

6. Shiqiang Yan#, Yueyue Zhu#, Yujie Wang, Qiang Xiao, Ning Ding*, Yingxia Li*. Total synthesis of leontopodioside A. Tetrahedron Letters, 2020, https://doi.org/10.1016/j.tetlet.2020.151886.

7. Xiying Wu, Hongmin Zhang, Shuhua He, Qin Yu, Yi Lu, Wei Wu, Ning Ding, Quangang Zhu, Zhongjian Chen, Yuhua Ma, Jianping Qi*. Improving dermal delivery of hyaluronic acid by ionic liquids for attenuating skin dehydration. International Journal of Biological Macromolecules, 2020, 150, 528–535 (https://doi.org/10.1016/j.ijbiomac.2020.02.072).

8. Shiqiang Yan, Mingxian Xie, Yujie Wang, Qiang Xiao, Ning Ding*, Yingxia Li*. Semi-synthesis of a series natural flavonoids and flavonoid glycosides from scutellarin. Tetrahedron, 2020, https://doi.org/10.1016/j.tet.2020.130950.

9. Sumei Ren, Ruiqi Liu, Yujie Wang, Ning Ding*, Yingxia Li*. Synthesis and biological evaluation of Ginsenoside compound K analogues as a novel class of anti-asthmatic agents. Bioorganic & Medicinal Chemistry Letters, 2019, 29, 51-55 (https://doi.org/10.1016/j.bmcl.2018.11.016).

10. Xianglai Liu#, Sumei Ren#,Qi Gao, Chun Hu*,Yingxia Li, and Ning Ding*.Glycosylation of a ketone with an O-glycosyl trichloroacetimidate provides an enol glycoside. Organic Letters2018, 20, 5186-5189 (https://doi.org/10.1021/acs.orglett.8b02126).

11. Sumei Ren, Yujie Wang, Junfei Wang, Dingding Gao, Minmin Zhang, Ning Ding*, Yingxia Li*. Synthesis and biological evaluation of novel larotaxel analogues. European Journal of Medicinal Chemistry2018, 156, 692-710 (https://doi.org/10.1016/j.ejmech.2018.07.029).

12. Ting Wang, Jianping Qi, Ning Ding, Xiaochun Dong, Weili Zhao, Yi Lu, Changhong Wang*, Wei Wu*. Tracking translocation of self-discriminating curcumin hybrid nanocrystals following intravenous delivery. International Journal of Pharmaceutics2018, 546, 10-19 (https://doi.org/10.1016/j.ijpharm.2018.05.020).

13. Qi Yan, Yuzhe Chen, Baiyou Tang, Qiang Xiao, Rong Qu, Linjiang Tong, Jian Liu, Jian Ding, Yi Chen, Ning Ding, Wenfu Tan*, Hua Xie*, Yingxia Li*. Discovery of novel 2,4-diarylaminopyrimidine derivatives as potent and selective epidermal growth factor receptor (EGFR) inhibitors against L858R/T790M resistance mutation. European Journal of Medicinal Chemistry2018, 152, 298-306 (https://doi.org/10.1016/j.ejmech.2018.04.052).

14. Shiqiang Yan, Sumei Ren, Ning Ding, Yingxia Li*. Concise total synthesis of acylated phenolic glycosides vitexnegheteroin A and ovatoside D. Carbohydrate Research 2018, 460, 41-46 (https://doi.org/10.1016/j.carres.2018.02.015).

15. Ning Ding, Xiuru Li, Zoeisha S. Chinoy, Geert-Jan Boons*. Synthesis of a glycosylphosphatidylinositol anchor derived from Leishmania donovani that can be functionalized by Cu-catalyzed azide-alkyne cycloadditions. Organic Letters 2017, 19, 3827−3830 (https://doi.org/10.1021/acs.orglett.7b01703).

16. Dongming Yao#, Yichu Liu#, Qi Gao, Qiang Sui, Xiaoping Liu*, Ning Ding*. A comparison of benzyl and 2-naphthylmethyl ethers as permanent hydroxyl protecting groups in the synthesis of alpha-galactoglycosphingolipids KRN7000 and PBS-57. Journal of Carbohydrate Chemistry2017, 36, 173-188  (https://doi.org/10.1080/07328303.2017.1375114)

17. Dongming Yao#, Yichu Liu#, Shiqiang Yan, Yingxia Li, Chun Hu, Ning Ding*. Evidence of robust participation by an equatorial 4-O group in glycosylation on a 2-azido-2-deoxy-glucopyranosyl donor. Chemical Communications2017, 53, 2986-2989 (https://doi.org/10.1039/C7CC00274B).

18. Yichu Liu, Xiaoyan Xu, Qi Gao, Shiqiang Yan, Yingxia Li, Ning Ding*. Rapid access to 6”-functionalized alfa-galactosyl ceramides by using 2-naphthylmethyl ether as the permanent protecting group. Bioorganic & Medicinal Chemistry Letters2017, 27, 1795-1798  (https://doi.org/10.1016/j.bmcl.2017.02.055).


联系我们
地址:上海浦东新区张衡路826号
电话:(021)51980001
邮编:201203