张伟
药物化学, 副教授, 硕士生导师


姓      名

 张伟

性      别

 男

职      称

 副教授

学      历

 博士

电      话

 021-51980120

传      真

  

电子邮件

 zhangw416@fudan.edu.cn

个人主页

  

通讯地址

 张衡路826号化学南楼405 

教育经历


2005.09 – 2008.06 中国海洋大学医药学院  博士

2002.09 – 2005.07 中国海洋大学医药学院  硕士

1998.09 – 2002.07 中国海洋大学化学化工学院  本科

工作经历


2015.12 – 至今      复旦大学药学院,副教授

2009.11 –  2015.11 复旦大学药学院,讲师
2012.01 – 2013.01  佛罗里达大学药学院,访问学者
2008.07 – 2009.10  中国海洋大学医药学院,讲师

 承担科研项目情况

1. 国家重点研发计划子课题(2018YFC0310906),主持

2. 国家自然科学基金面上项目(81573340),主持
3. 国家自然科学基金青年项目(81001392),主持
4. 复旦大学卓学人才计划,主持
5. 重大新药创制专项(2009ZX09102-014),参与(课题副组长)

 

获奖及荣誉

2014.05  复旦大学药学院青年教师讲课比赛一等奖

2014.11  第四届全国高等医学院校青年教师教学基本功比赛三等奖
2015.01  复旦大学第一三共制药奖教金 


研究方向


1. 基于活性天然产物的药物研究

2. 药物优势骨架的高效构建

 

代表性论著


1. Wu Ping#, Xu Senhan#, Xu Hao, Hu Haiyan, Zhang Wei*. One-pot synthesesof α,α-dibromoacetophenones from aromatic alkenes with1,3-dibromo-5,5-dimethylhydantoin. Tetrahedron Letters, 2017, 58, 618–621.

2. Xu Hao#, Bao Keting#, Tang Shuai, Ai Jing*, Hu Haiyan*, Zhang Wei*.Cyanobacterial peptides as a prototype for the design of cathepsin Dinhibitors. Journal of Peptide Science, 2017, 23, 701–706.

3. Wu Ping#, CaiWeijing#, Chen Qi-Yin, Xu Senhan, Yin Ruwen, Li Yingxia, Zhang Wei*, LueschHendrik*. Total synthesis and biological evaluation of apratoxin E and its C30epimer: Configurational reassignment of the natural product. Organic Letters,2016, 18, 5400–5403.

4. Xu Senhan#, Wu Ping#, Zhang Wei*.1,3-Dibromo-5,5-dimethylhydantoin (DBH) mediated one-pot syntheses ofα-bromo/amino ketones from alkenes in water. Organic & BiomolecularChemistry, 2016, 14, 11389-11395.

5. Yan Qi, Wang Yujie, Zhang Wei*, Li Yingxia*. Novelazetidine-containing TZT-1027 analogues as antitumor agents. Marine Drugs,2016, 14, 85.

6. Liu Shihui#, ChenXiaobei#, Hu Yanwei*, Yuan Laiqi, Chen Shaohua, Wu Ping, Wang Wei, Zhang Shilei*,Zhang Wei*. An efficient method for the production of terminal alkynes from1,1-dibromo-1-alkenes and its application in the total synthesis of naturalproduct dihydroxerulin. Advanced Synthesis & Catalysis, 2015, 357, 553–560.

7. Liu Jian, Chen Wuyan,Xu Yechun, Ren Sumei, Zhang Wei*, Li Yingxia*. Design, synthesis and biologicalevaluation of tasiamide B derivatives as BACE1 inhibitors. Bioorganic &Medicinal Chemistry, 2015, 23, 1963–1974.

8. Zhang Wei, Sun Tiantian, Ma Zhenhua, Li Yingxia*.Design, synthesis and biological evaluation of tasiamide analogues as tumorinhibitors. Marine Drugs, 2014, 12, 2308?2325.

9. Zhang Wei#, AiJing#, Shi Dakuo, Peng Xia, Ji Yinchun, Liu Jian, Geng Meiyu*, Yingxia Li*.Discovery of novel type II c-Met inhibitors based on BMS-777607. EuropeanJournal of Medicinal Chemistry, 2014, 80, 254–266.

10. Liu Yanxia#,Zhang Wei#, Li Li#, Salvador, Lilibeth A., Chen Tiantian, Chen Wuyan, FelsensteinKevin M., Ladd Thomas B., Price Ashleigh R., Golde Todd E., He Jianhua, XuYechun*, Li Yingxia*, Luesch Hendrik*. Cyanobacterial peptides as a prototypefor the design of potent β-secretase inhibitors and the development ofselective chemical probes for other aspartic proteases. Journal of MedicinalChemistry, 2012, 55, 10749–10765.

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