李炜
药物化学, 副教授, 硕士生导师

姓      名

 李炜

性      别

 男

职      称

 副教授

学      历

 博士

电      话

 

传      真

 

电子邮件

 wei-li@fudan.edu.cn

个人主页

 

通讯地址

 上海市浦东新区张衡路826号复旦大学张江校区

 

教育经历
1998.9-2002.7  复旦大学药学院药学专业本科

2002.9–2004.7 复旦大学药学院药物化学教研室硕士研究生

2004.9-2007.7  复旦大学药学院药物化学教研室博士研究生


工作经历
2016.12 – 至今        复旦大学药学院,副教授

2012.10– 2013.10   Medicinal Chemistry Laboratory, Alcohol and Drug Abuse Research Center, McLean Hospital | Psychiatric affiliate of Harvard Medical School,访问学者

2007.7 – 2016.11    复旦大学药学院,讲师


研究方向
1.  阿片受体配基及相关中枢神经系统疾病治疗药物的研究

2.  多样性导向化合物库的设计及其中枢神经系统疾病治疗药物发现中的应用


代表性论著

1. Xiao Liu#, Shuang Jiang#, Linghui Kong#, Rongrong Ye#, Li Xiao, Xuejun Xu, Qian He, Yuanyuan Wei, Zixiang Li, Huijiao Sun, Qiong Xie, Xu Xu, Yan Lu, Yujun Wang*, Wei Li*, Wei Fu, Zhuibai Qiu, Jinggen Liu*, Liming Shao*. An Exploration of the SAR Connection Between Morphinan and Arylacetamide-based κ Opioid Receptor (κOR) Agonists using the Strategy of Bridging. ACS Chem NeuroSci, 2021, 12(6), 1018-1030.

2. Huoming Huang, Xinwei Li, Wei Guo, Chen Zhu, Yuanyuan Qian, Qing Shen, Xuejun Xu, Wei Li, Yujun Wang*, Wei Fu*. Design, Synthesis, and Structure–Activity Relationship Exploration of Alkyl/Phenylalkyl Piperidine Analogues as Novel Highly Potent and Selective μ Opioid Receptor Agonists. ACS Chem NeuroSci, 2021, 12(2), 285–299.

3. Yijie Xue#, Dengqi Xue#, Qian He, Qianwei Ge, Wei Li, Liming Shao*. Additive-Free Radical Cascade Reaction of Oxime Esters: Synthesis of Pyrroline-Functionalized Phenanthridines. J Org Chem, 2020, 85, 12284-12293.

4. Bangyi Zhao#, Wei Li#, Lijie Sun, Wei Fu*. The Use of Computational Approaches in the Discovery and Mechanism Study of Opioid Analgesics. Front Chem, 2020, 8: 335.

5. Chen Zhu, Xinwei Li, Bangyi Zhao, Weiqing Peng, Wei Li, Wei Fu*. Discovery of aryl-piperidine derivatives as potential antipsychotic agents using molecular hybridization strategy. Eur J Med Chem, 2020, 193: 112214.

6. Huoming Huang, Wenli Wanga, Xuejun Xu, Chen Zhu, Yujun Wang, Jinggen Liu*, Wei Li*, Wei Fu*. Discovery of 3-((dimethylamino)methyl)-4-hydroxy-4-(3-methoxyphenyl)-N-phenylpiperidine-1-carboxamide as novel potent analgesic. Eur J Med Chem, 2020, 189: 112070.

7. Wenli Wang#, Lan Zheng#, Wei Li, Chen Zhu, Weiqing Peng, Bing Han*, Wei Fu*. Design, Synthesis, and Structure–Activity Relationship Studies of Novel Indolyalkylpiperazine Derivatives as Selective 5-HT1A Receptor Agonists. J Chem Inf Model, 2020, 60(1): 235-248.

8. Li Xiao# , Yujun Wang #, Mumei Zhang #, Weiwei Wu #, Linghui Kong, Yan Ma, Xuejun Xu, Xiao Liu, Qian He, Yuanyuan Qian, Huijiao Sun, Haihao Wu, Cheng Lin, Huoming Huang, Rongrong Ye, Shuang Jiang, Rufeng Ye, Congmin Yuan, Shengyang Fang, Dengqi Xue, Xicheng Yang, Hao Chen, Yilin Zheng, Linqian Yu, Qiong Xie, Lan Zheng, Wei Fu, Wei Li*, Zhuibai Qiu, Jinggen Liu *, Liming Shao*. Discovery of a highly selective and potent kappa opioid receptor agonist from N-cyclopropylmethyl-7α-phenyl-6,14-endoethano-tetrahydronorthebaines with reduced central nervous system (CNS) side effects navigated by the message-address concept. J Med Chem, 2019, 62(24): 11054-11070.

9. Xicheng Yang, Jian Shen, Lulu Jiang, Wei Li, Mingcheng Yu, Guanxing Pan, Yurong Yan, Chenghan Zhang, Wanwan Jia, Li Xiao, Haihua Yu, Hao Chen, Yilin Zheng, Linqian Yu, Qiong Xie*, Lu Zhou*, Liming Shao*. Discovery,cocrystallization and biological evaluation of novel piperidine derivatives as high affinity Ls-AChBP ligands possessing alpha-7nAChR activities. Eur J Med Chem, 2018, 160,37-48.

10. Huijiao Sun, Yuhua Wang, Congmin Yuan, Linghui Kong, Xuejun Xu, Yujun Wang, Haihao Wu, Cheng Lin, Yuanyuan Qian, Huoming Huang, Li Xiao, Xiao Liu, Qian He, Shengyang Fang, Dengqi Xue, Xicheng Yanga, Hao Chen, Yilin Zheng, Lan Zheng, Linqian Yu, Qiong Xie, Wei Fu, Wei Li*, Jinggen Liu*, Zhuibai Qiu, Liming Shao*. 7β-methyl substituent is a structural locus associated with activity cliff for nepenthone analogues. Bioorg Med Chem, 2018, 26 (14), 4254-4263.

11. Yulong Xu, Hao Chen, Wei Li, Qiong Xie, Linqian Yu, Liming Shao*. Synthetic access to isoxazoline-functionalized isoquinolines via microwave-assisted iminoxyl radical-participated cascade cyclization of vinyl isocyanides. Org Biomol Chem, 2018, 16 (27): 4996-5005.

12. Yulong Xu, Xicheng Yang, Yiyi Chen, Hao Chen, Huijiao Sun, Wei Li, Qiong Xie, Linqian Yu, Liming Shao*. Discovery of novel 20S proteasome inhibitors by rational topology-based scaffold hopping of bortezomib Bioorg Med Chem Lett, 2018, 28 (12), 2148-2152.

13. Wei Li#, Jiandong Long#, Yuanyuan Qian#, Yu Long, Xuejun Xu, Yujun Wang, Qing Shen, Zuoneng Wang, Xicheng Yang, Li Xiao, Hongpeng Sun, Yulong Xu, Yiyi Chen, Qiong Xie, Yonghui Wang, Liming Shao, Jinggen Liu*, Zhuibai Qiu, Wei Fu*. The Pharmacological Heterogeneity of Nepenthone Analogs in Conferring Highly Selective and Potent kappa-Opioid Agonistic Activities. ACS Chem NeuroSci, 2017, 8 (4), 766–776.


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