教育经历2004.9.-2007.6:复旦大学药学院药物化学专业,博士
2000.9.-2003.6:复旦大学药学院药物化学专业,硕士
1993.9.-1997.6:华东师范大学化学系化学专业,学士
工作经历2013.12- 至今:复旦大学药学院药物化学教研室,副教授
2008.9 -2009.9:美国明尼苏达大学药学院药物化学系,博士后
1997.7- 2013.11:复旦大学药学院药物化学教研室,助教/讲师
承担科研项目情况1. 上海市“科技创新行动计划”生物医药科技支撑专项项目(21S11907200),新型双阳离子硼修饰BODIPY抗菌光敏剂的临床前研究,主持
2. 上海市“科技创新行动计划”自然科学基金项目(21ZR1425600),新型小分子Myostatin通路抑制剂的设计、合成及其抗肿瘤恶病质作用研究,主持
3. 国家自然科学基金面上项目(21572037),新结构类型Hedgehog通路抑制剂的设计、合成和构效关系研究,主持
4. 上海市自然科学基金面上项目(12ZR1403300),含氮杂四元环骨架的新型Hedgehog通路抑制剂的设计、合成及抗肿瘤活性研究,主持
5. 国家自然科学基金面上项目(81573363),基于水淬灭近红外荧光探针的口服脂质纳米给药系统体内命运与作用机制研究,参与
6. 国家自然科学基金面上项目(81872816),新型水淬灭近红外荧光探针的设计及其在纳米粒体内过程研究中的应用,参与
研究方向1. 基于分子靶向、肿瘤信号通路及免疫相关小分子抗肿瘤药物先导化合物研究
2. 有机药物合成方法研究
代表性论著
1. Zhiliang Yu, Junliang Zhou,Xin Ji, Guangyu Lin, Shuang Xu, Xiaochun Dong*, Weili Zhao*.Discovery of a Monoiodo Aza-BODIPY Near-Infrared Photosensitizer: in vitro andin vivo Evaluation for Photodynamic Therapy. J. Med. Chem., 2020,63 (17): 9950-9964
2. Kedan Gu, Guangyu Lin,Yuanxing Zhu, Xin Ji, Jiyang Li*, Xiaochun Dong*, Weili Zhao*.Anchoring BODIPY photosensitizers enable pan-microbial photoinactivation. Eur.J Med. Chem., 2020, 199: 1123613. Zhifeng Xia, Yanyang Nan,Chang Liu, Guangyu Lin, Kedan Gu, Cheng Chen, Weili Zhao, Dianwen Ju, XiaochunDong*. Design, Synthesis and Biological Evaluation of Novel1,2,5-Oxadiazol-3-Carboximidamide Derivatives as Indoleamine 2, 3-Dioxygenase 1(IDO1) Inhibitors. Anti-Cancer Agents in Medicinal Chemistry, 2020,20: 1592-16034. Mingfei Zhu, Hong Wang, Chenglin Wang, Yanfen Fang, Tong Zhu, Weili Zhao, Xiaochun Dong*, Xiongwen Zhang*. L-4, a well-tolerated and orally active inhibitor of hedgehog pathway, exhibited potent anti-tumor effects against medulloblastoma in vitro and in vivo. Front. Pharmacol., 2019, 10, e89.5.Xiaochun Dong, Chenglin Wang, Zhongjian Chen*, Weili Zhao*. Overcoming the Resistance mechanisms of Smoothened inhibitors, Drug Discovery Today, 2018, 23: 704-7106. Chenglin Wang, Mingfei Zhu,Xiuhong Lu, Hong Wang, Weili Zhao, Xiongwen Zhang*, Xiaochun Dong*.Synthesis and evaluation of novel dimethylpyridazine derivatives as hedgehogsignaling pathway inhibitors. Bioorg. Med. Chem., 2018,26, 3308-33207. Xiuhong Lu, ZhongjianChen*, Xiaochun Dong*, Weili Zhao*. Water -Soluble FluorescentProbe with Dual Mitochondria/Lysosome Targetability for Selective SuperoxideDetection in Live Cells and in Zebrafish Embryos. ACS Sensors, 2018,3: 59-648. Xiuhong Lu, Yuanqiu Peng,Chenglin Wang, Jun Yang, Xiaolong Bao, Qian Dong, Weili Zhao*, WenfuTan*, Xiaochun Dong*. Design, synthesis, and biological evaluationof optimized phthalazine derivatives as hedgehog signaling pathwayinhibitors. Eur. J Med. Chem., 2017, 138, 384-395.9. Feng Yang, Wen Wang, KaidiLi, Weili Zhao*, Xiaochun Dong*. Efficient one-pot construction ofunsymmetrical disulfide bonds with TCCA. Tetrahedron Lett., 2017,58, 218–222.10. Xiaolong Bao, YuanqiuPeng, Xiuhong Lu, Jun Yang, Weili Zhao*, Wenfu Tan*, Xiaochun Dong*.Synthesis and evaluation of novel benzylphthalazine derivatives as hedgehogsignaling pathway inhibitors. Bioorg. Med. Chem, Lett., 2016,26, 3048-3051