程志红

天然药物学, 教授, 博士生导师

发布时间:2021-05-10浏览次数:8481

姓      名

 程志红

性      别

 男

职      称

 教授

学      历

 博士

电      话

 021-51980137

传      真

 021-51980017

电子邮件

 chengzhh@fudan.edu.cn

个人主页


通讯地址

 上海市浦东新区张衡路826号复旦大学药学院


教育经历

1998.09 – 2003.06 中国药科大学中药学院,生药学博士
 1994.09 – 1998.06 中国药科大学中药学院,中药分析学学士

 

工作经历

2018.12 -- 今 复旦大学药学院,教授

2009.01 – 2018.12 复旦大学药学院,副研究员

2005.10 – 2008.08 美国马里兰大学(University of Maryland at College Park),博士后
 2003.07 – 2005.09 中科院上海有机化学研究所,博士后


获奖及荣誉
2011.01 教育部自然科学二等奖-麦冬类中药的系统研究(第三完成人)


承担科研项目情况

1.主持国家自然科学基金面上项目:基于薄层自显影谱效关系-生物定量法的板蓝根抗流感病毒活性成分辨识与质量控制研究(82173967, 2022.01-2025.12);

2.主持上海市科委自然科学基金面上项目基于微生物转化和化学修饰探讨续随子烷二萜抑制肿瘤多药耐药性的构效关系(19ZR1406100, 2019.07-2022.07);

3.主持国家自然科学基金面上项目:维药天山堇菜和一枝蒿治疗重症流感的物质基础研究(81473421, 2015.01-2018.12);

4.主持国家自然科学基金面上项目:基于补体抑制作用探讨紫花地丁和夏枯草的清热药效物质(81073025, 2011.01-2013.12);

5.主持教育部博士点基金(新教师类):清热药夏枯草的清热药效物质基础研究, (20100071120052, 2011.01-2013.12);

6.主持上海市科委中药现代化专项基金:紫花地丁清热药效物质基础及其对急性肺损伤的防治作用(09dZ1970100, 2009.06-2012.06);

7.承担“国家重大新药创制” 科技重大专项课题: 中药药效物质基础及物质资源库研究关键技术(2009ZX09502-013, 2009.1-2010.12, 课题副组长)。


研究方向
1. 中草药的药效物质基础及质量控制研究;

2. 小分子天然产物的微生物转化研究。


代表性论著

1.Yichao Zang, Yu Miao, Tao Wu*, Zhihong Cheng*. Development of a thin-layer chromatography bioautographic assay for neuraminidase inhibitors hyphenated with electrostatic field induced spray ionisation-mass spectrometry for identification of active Isatis indigotica root compounds. Journal of Chromatography A, 2021, 1638: 461597;

2.Qihui Guo, Zeyun Li, Lulu Shen, Ying Xiao*, Zhihong Cheng*. Quantitative 1H nuclear magnetic resonance (qHNMR) methods for accurate purity determination of glucosinolates isolated from Isatis indigotica roots. Phytochemical Analysis, 2021, 32: 104-111;

3.Haiyan Feng, Jihe Tang, Peiliang Zhang, Yu Miao, Tao Wu*, Zhihong Cheng*. Anti-adipogenic 18,19-seco-ursane stereoisomers and oleane-type saponins from Ilex cornuta leaves. Phytochemistry, 2020, 175: 112363;

4.Pei-Lan Ding, Chang-Ming He, Zhi-Hong Cheng*, Dao-Feng Chen*. Flavonoids rather than alkaloids as the diagnostic constituents to distinguish Sophorae Flavescentis Radix from Sophorae Tonkinensis Radix et Rhizoma: an HPLC fingerprint study. Chinese Journal of Natural Medicines, 2018, 16(12): 951-960;

5.Yan Qin, Boyan Gao, Haiming Shi, Jie Cao, Chengle Yin, Weiying Lu, Liangli Yu, Zhihong Cheng*. Characterization of flavonol mono-, di-, tri- and tetra-O-glycosides by ultra-performance liquid chromatography-electrospray ionization-quadrupole time-of-flight mass spectrometry and its application for identification of flavonol glycosides in Viola tianschanica. Journal of Pharmaceutical and Biomedical Analysis, 2017,142: 113-124;

6.Lei Zhang, Jiyao Shi, Jihe Tang, Zhihong Cheng*, Xiaohui Lu, Yao Kong, Tao Wu*. Direct coupling of thin-layer chromatography-bioautography with electrostatic field induced spray ionization-mass spectrometry for separation and identification of lipase inhibitors in lotus leaves. Analytica Chimica Acta, 2017, 967: 52-58; 

7.Yiqing Wu, Chengle Yin, Yue Cao, Xin Liu, Jinxiang Yu, Jian Zhang, Boyang Yu, Zhihong Cheng*. Regioselective hydroxylation of lathyrane diterpenoids biocatalyzed by microorganisms and its application in integrated synthesis. Journal of Molecular Catalysis B: Enzymatic, 2016, 133: S352-S359;

8.Dongsheng Du, Yan Lu, Zhihong Cheng*, Daofeng Chen*. Structure characterization of two novel polysaccharides isolated from the spikes of Prunella vulgaris and their anticomplement activities. Journal of Ethnopharmacology, 2016, 193: 345-353;

9.Yan Qin, Yingming Pang, Zhihong Cheng*. Needle trap device as a new sampling and preconcentration approach for volatile organic compounds of herbal medicines and its application to the analysis of volatile components in Viola tianschanica. Phytochemical Analysis, 2016, 27(6): 364-374;

10.Chengle Yin, Jinge Zhou, Yiqing Wu, Yue Cao, Tao Wu, Shoude Zhang, Honglin Li, Zhihong Cheng*. Pterocarpans and triterpenoids from Gueldenstaedtia verna. Fitoterapia, 2015, 106: 46-54;

11.Dongsheng Du, Zhihong Cheng*, Daofeng Chen*. Anti-complement sesquiterpenes from Viola yedoensis. Fitoterapia, 2015, 101: 73-79;

12.Jie Cao, Chengle Yin, Yan Qin, Zhihong Cheng*, Daofeng Chen. Approach to the study of flavone di-C-glycosides by high performance liquid chromatography-tandem ion trap mass spectrometry and its application to characterization of flavonoid composition in Viola yedoensis. Journal of Mass Spectrometry, 2014, 49: 1010-1024;

13.Zhihong Cheng, Huiping Zhou, Marla Luther, Junjie Yin, Liangli (Lucy) Yu*. Effects of wheat antioxidants on oxygen diffusion-concentration products in liposomes and key genes for cholesterol biosynthesis and metabolism in primary rat hepatocytes. Journal of Agricultural & Food Chemistry, 2008, 56(13): 5033-5042;

14.Zhihong Cheng, Yinlong Guo*, Haoyang Wang, Guoqiang Chen. Qualitative and quantitative analysis of quaternary ammonium alkaloids from Rhizoma Corydalis by MALDI-FTMS coupled with a special precipitation reaction using Reinecke salt. Analytica Chimica Acta, 2006, 555: 269-277;

15.Zhihong Cheng, Boyang Yu*, Cordell Geoffrey A., Shengxiang Qiu*. Biotransformation of quinovic acid glycosides by microbes: direct conversion of the ursane to the oleanane triterpene skeleton by Nocardia sp. NRRL 5646. Organic Letters, 2004, 6(18): 3163-3165.


联系我们
地址:上海浦东新区张衡路826号
电话:(021)51980001
邮编:201203