姓 名 | 魏邦国 | 性 别 | 男 |
职 称 | 研究员 | 学 历 | 博士研究生 |
电 话 |
| 传 真 | |
电子邮件 | bgwei1974@fudan.edu.cn | 个人主页 | |
通讯地址 | 上海市浦东新区张衡路826号南楼211 |
教育经历 1994.09 – 1998.07 西北师范大学化学系
1998.09 – 2001.07 西北师范大学化学化工学院 有机化学专业 硕士研究生
2001.09 – 2004.09 厦门大学化学化工学院 有机化学专业 博士研究生
工作经历 2004.10 – 2006.08 中国科学院上海有机化学研究所,博士后
2006.8 – 2016.12 复旦大学化学系,副研究员
2016.12 –今 复旦大学药学院,副研究员,研究员
研究方向
1. 活性导向天然产物高效合成方法学研究
2. 资源导向复杂海洋天然产物的不对称合成研究;
3. 含氮杂环生物碱的多样性合成及高效工艺研究;
主要科研贡献
以活性天然产物的多样性合成为导向,取得了如下研究结果:
1. 首次发现了官能化烷基锌试剂促进的叔丁基S-C 1,3-迁移新反应,建立了取代叔亮氨酸的高效合成方法。
2. 基于邻位诱导的串联环合反应建立了1类新药苦马豆素、常山酮公斤级的制备工艺;
3. 以高效合成策略为导向,完成了多个具有重要生理活性天然产物的不对称合成。
承担科研项目情况
1. 国家自然科学基金面上项目:
① 构象锁定小分子直链肽Dolastatin 10, Grassystatin A,Tubulysins和Symplocin A 多样性研究 (21772027)
② 基于抗体药物偶联物弹头的具有抗肿瘤活性海洋天然产物Hoiamides A、Lyngbyabellin N等的多样性研究(21472022);
③ 具有重要生理活性海洋环肽酯Lagunamide、Apratoxins及其氟代类似物的合成和活性评价研究 (21272041);
④具有抗癌活性海洋天然产物 Leiodelide A、B 及其类似物全合成和生理活性评价研究 (21272041)
⑤ 新型抗凝血酶抑制剂的合成 (20702007)
2. 国家自然科学基金重点项目:
重要生理活性天然产物的结构多样性合成研究 (20832005, 复旦子课题负责人,总课题由厦门大学黄培强教授主持)2012.05 第二十四届上海市优秀发明选拔赛优秀发明 金奖 (第二完成人)
2011.12 上海市药学会科技奖 二等奖(第二完成人)
2011.07 中国药学会科技奖 二等奖(第七完成人)
2010.12 上海市药学会科技奖 二等奖(第七完成人)
2005.04 甘肃省科技进步奖 二等奖 (第七完成人)
2004.07 甘肃省高校科技进步奖 一等奖 (第七完成人)
2002.10 甘肃省高校科技进步奖 二等奖 (第五完成人)
1. Zhuo-Ya Mao, Yi-Wen Liu, Rui-Jun Ma, Chang-Mei Si, Bang-Guo Wei* and Guo-Qiang Lin Divergent Synthesis of N-Heterocyclic 1,6-Enynes through Zinccatalyzed Decarboxylative A3 Reaction Chemical Communications 2019 Revised.
2. Yi-Wen Liu, Zhuo-Ya Mao, Xiao-Di Nie, Chang-Mei Si, Bang-Guo Wei* and Guo-Qiang Lin An Effective Approach to Tertiary Type β-Hydroxyl Carboxamides Through Sc(OTf)3-Catalyzed Addition of Ynamides and Ketones Organic Letters 2019, Under review.
3. Chen Wang, Zhuo-Ya Mao, Yi-Wen Liu, Qiao-E Wang, Chang-Mei Si, * Bang-Guo Wei * and Guo-Qiang Lin Stereoselective Intermolecular [4+2] Process of N,O-acetal with Terminal Alkynes for Construction of Functional cis-Pyrido and Pyrrolo[1,2-c][1,3]oxazin-1-ones Advanced Synthesis & Catalysis 2019, Under review.
4. Pan Han, Zhuo-Ya Mao, Chang-Mei Si, Zhu Zhou, Bang-Guo Wei* and Guo-Qiang Lin Stereoselective Synthesis of Pyrido- and Pyrrolo [1,2?c][1,3]oxazin-1-ones via a Nucleophilic Addition?Cyclization Process of N,O?Acetal with Ynamides Journal of Organic Chemistry 2019, 84, 914?923;
5. Xue-Mei Wang, Yi-Wen Liu, Rui-Jun Ma, Chang-Mei Si,* and Bang-Guo Wei* Synthesis of 1,4- and 1,5-Amino Alcohols via Nucleophilic Addition of Semicyclic N,O?Acetal with Organozinc Reagents Journal of Organic Chemistry 2019, 84, 11261?11267;
6. Zhuo-Ya Mao, Yi-Wen Liu, Pan Han, Han-Qing Dong, Chang-Mei Si,* Bang-Guo Wei* and Guo-Qiang Lin Regio- and Stereoselective Cascades via Aldol Condensation and 1,3-Dipolar Cycloaddition for Construction of Functional Pyrrolizidine Derivatives Organic Letters 2018, 20, 1090?1093;
7. Wen Zhou, Yan-Xue Zhang, Xiao-Di Nie, Chang-Mei Si,* Xun Sun, and Bang-Guo Wei* Approach to Chiral 1?Substituted Isoquinolone and 3?Substituted Isoindolin-1-one by Addition?Cyclization Process Journal of Organic Chemistry 2018, 83, 9879?9889;
8. Pan Han, Zhu Zhou, Chang-Mei Si,* Xian-Yi Sha, Zheng-Yi Gu, Bang-Guo Wei* and Guo-Qiang Lin Asymmetric Synthesis of Rupestonic Acid and Pechueloic Acid Organic Letters 2017, 19, 6732?6735;
9. Zhuo-Ya Mao, Chang-Mei Si, Yi-Wen Liu, Han-Qing Dong, Bang-Guo Wei* and Guo-Qiang Lin Divergent Synthesis of Revised Apratoxin E, 30-epi-Apratoxin E, and
30S/30R?Oxoapratoxin E Journal of Organic Chemistry 2017, 82, 10830-10845;
10. Lu-Ping Shao, Chang-Mei Si, Zhuo-Ya Mao, Wen Zhou, Tadeusz F. Molinski,* Bang-Guo Wei* and Guo-Qiang Lin Synthesis and structure revision of symplocin A Organic Chemistry Frontiers, 2017, 4, 995–1004;
11. Chang-Mei Si, Zhuo-Ya Mao, Yi-Wen Liu, Zhen-Ting Du, Bang-Guo Wei* and Guo-Qiang Lin Stereoselective Formation of Chiral trans-4-Hydroxy-5-Substituted 2-Pyrrolidinones: Syntheses of Streptopyrrolidine and 3-epi-Epohelmin A Organic Chemistry Frontiers 2015, 2, 1485-1499;
12. Chang-Mei Si, Zhuo-Ya Mao, Han-Qing Dong, Zhen-Ting Du, Bang-Guo Wei* and Guo-Qiang Lin Divergent Method to trans-5-Hydroxy-6-alkynyl/alkenyl-2-piperidinones: Syntheses of (-)-Epiquinamide and (+)-Swainsonine Journal of Organic Chemistry 2015, 80, 5824-5833;
13. Chang-Mei Si, Wei Huang, Zhen-Ting Du, Bang-Guo Wei* and Guo-Qiang Lin Diastereoconvergent Synthesis of trans-5-Hydroxy-6-Substituted-2-Piperidinones by Addition?Cyclization?Deprotection Process Organic Letters 2014, 16, 4328?4331.
14. Wei Huang, Jian-Liang Ye, Wei Zheng, Han-Qing Dong and Bang-Guo Wei* Radical Migration?Addition of N-tert-Butanesulfinyl Imines with Organozinc Reagents Journal of Organic Chemistry 2013, 78, 11229?11237.
15. Wei Huang, Rong-Guo Ren, Han-Qing Dong, Bang-Guo Wei* and Guo-Qiang Lin Diverse Synthesis of Marine Cyclic Depsipeptide Lagunamide A and Its Analogues Journal of Organic Chemistry 2013, 78, 10747?10762.