雷春

天然药物学, 副教授, 博士生导师

发布时间:2021-05-10浏览次数:4992

姓      名

 雷春

性      别

 女

职      称

 副教授

学      历

 博士

电      话

 51980173

传      真

 51980173

电子邮件

 chunlei@fudan.edu.cn

个人主页

 无

通讯地址

 上海市浦东新区金科路3728号


教育经历

1998.09 – 2002.07 南京农业大学园艺学院,学士
2002.09 – 2005.01 南京农业大学,作物遗传与种质创新国家重点实验室,硕士
2005.03 – 2008.03 中国科学院昆明植物研究所,植物化学与西部植物资源持续利用国家重点实验室,博士

 

工作经历
2008.04 – 2010.11 上海有机化学研究所,生命有机化学国家重点实验室,博士后
2010.11 – 2014.12 复旦大学药学院,讲师
2015.01 – 至今 复旦大学药学院,副教授    
 
研究方向

天然先导化合物的发现与研究


承担科研项目情况

1)国家自然科学基金面上项目,清热解毒傣药鹊肾树抗病毒活性成分的发现与研究(82073717)

2)国家自然科学基金面上项目,新异戊烯基酚类化合物的发现与抗糖尿病功能研究(21372049)

3)国家自然科学基金青年基金项目,以发掘基因组信息为基础的新颖硫肽类天然产物的发现研究(20902102)

4)第45批中国博士后科学基金面上资助一等资助,以挖掘基因组信息为基础的新颖抗生素的发现研究(20090450084)


代表性论著

1) Kai Jiang, Xiaoli Yan, Zixin Deng, Chun Lei*, Xudong Qu*. Expanding the Chemical Diversity of Fasamycin Via Genome Mining and Biocatalysis. Journal of Natural Products 2022, 85: 943-950.

2) Chun Lei, Ya-Nan Li, Jia-Nan Li, Yu-Bo Zhou, Ming-Jun Cui, Kai-Cong Fu, Jia Li, Ai-Jun Hou*. Two New Cytotoxic Maytansinoids Targeting Tubulin from Trewia nudiflora. Planta Medica 2022, 88: 678-684.

3) Jian-Fa Zong, Meng-Meng Zhang, Yu-Bo Zhou, Jia Li, Ai-Jun Hou*, Chun Lei*. Polyprenylated acylphloroglucinol meroterpenoids with PTP1B inhibition from Hypericum forrestii. Fitoterapia 2021, 153: 104959.

4) Xiao-Tong Zhao #, Chun Lei #, Jin-Qiu You, Ting Zhao, Mei-Hua Yu, Xun-Long Shi, Xiao Hu*, Ai-Jun Hou*. Dimeric clerodane diterpenoids and antiviral constituents of Dodonaea viscosa. Bioorganic Chemistry 2021, 112: 104916.

5) Chun Lei, Xiao-Hang Wang, Yi-Nan Liu, Ting Zhao, Zhu Hu, Jing-Ya Li, Ai-Jun Hou*. Clerodane diterpenoids from Dodonaea viscosa and their inhibitory effects on ATP citrate lyase. Phytochemistry 2021, 183: 112614.

6) Xiao-Tong Zhao, Mei-Hua Yu, Shi-Yun Su, Xun-Long Shi, Chun Lei*, Ai-Jun Hou*. Cycloartane triterpenoids from Pseudolarix amabilis and their antiviral activity. Phytochemistry 2020, 171: 112229.

7) Chun Lei, Qing-Hua Huang, Ting Zhao, Pei-Pei Wang, Jing-Ya Li, Jia Li, Ai-Jun Hou*. New triterpenoids and PTP1B inhibitory constituents of Pseudolarix amabilis. Fitoterapia 2019, 139: 104414.

8) Xian-Yi Mei, Xiao-Li Yan, Hui Zhang, Ming-Jia Yu, Guang-Qing Shen, Lin-Jun Zhou, Zi-Xin Deng, Chun Lei*, Xu-Dong Qu*. Expanding the bioactive chemical space of anthrabenzoxocinones through engineering the highly promiscuous biosynthetic modification steps. ACS Chemical Biology 2018, 13: 200-206.

9) Mei-Hua Yu, Zheng-Feng Shi, Bang-Wei Yu, En-Hao Pi, He-Yao Wang, Ai-Jun Hou, Chun Lei*. Triterpenoids and α-glucosidase inhibitory constituents from Salacia hainanensis. Fitoterapia 2014, 98: 143-148.

10) Chun Lei, Sheng-Xiong Huang, Wei-Lie Xiao, Xiao-Nian Li, Jian-Xin Pu*, Han-Dong Sun*. Schisanartane Nortriterpenoids with Diverse Post-modifications from Schisandra propinqua var. propinqua. Journal of Natural Products 2010, 73: 1337-1343.


联系我们
地址:上海浦东新区张衡路826号
电话:(021)51980001
邮编:201203