李炜

代表性论著                                                   

1. Zixiang Li, Rufeng Ye, Qian He, Jiashuo Lu, Yanting Sun, Xiujian Sun, Siyuan Tang, Shuyang Hu, Jingrui Chai, Linghui Kong, Xiaoning Liu, Jing Chen, Yun Fang, Yingjie Lan, Qiong Xie, Jinggen Liu*, Liming Shao*, Wei Fu, Yujun Wang*, Wei Li*. Discovery of an Ortho-Substituted N-Cyclopropylmethyl- 7α-phenyl-6,14-endoethano-tetrahydronorthebaine Derivative as a Selective and Potent Kappa Opioid Receptor Agonist with Subsided Sedative Effect. J Med Chem, 2024, DOI: 10.1021/acs.jmedchem.3c02439

2. Linghui Kong, Kuan Ning, Xiao Liu, Jiashuo Lu, Baiyu Chen, Rongrong Ye, Zixiang Li, Shuang Jiang, Siyuan Tang, Jingrui Chai, Yun Fang, Yingjie Lan, Xiaobo Mai, Qiong Xie, Jinggen Liu*, Liming Shao*, Wei Fu, Yujun Wang*, Wei Li*. Reversal of Subtype-Selectivity and Function by the Introduction of a Para-Benzamidyl Substituent to N-cyclopropylmethyl Nornepenthone. Eur J Med Chem, 2023, Oct 5;258:115589. https://doi.org/10.1016/j.ejmech.2023.115589

3. Linghui Kong, Xuelian Shu, Siyuan Tang, Rongrong Ye, Huijiao Sun, Shuang Jiang, Zixiang Li, Jingrui Chai, Yun Fang, Yinjie Lan, Linqian Yu, Qiong Xie, Wei Fu, Yujun Wang*, Wei Li*, Zhuibai Qiu, Jinggen Liu*, and Liming Shao*. SLL-627 is a highly selective and potent κ opioid receptor (KOR) agonist with an unexpected non-reduction in locomotor activity. J Med Chem, 2022, 65(15), 10377-10392. https://doi.org/10.1021/acs.jmedchem.2c00014

4. Yuanyuan Wei, Yan Ma, Songyu Yao, Linghui Kong, Xiao Liu, Jingrui Chai, Jing Chen, Wei Li*, Yujun Wang*, Liming Shao*, Jinggen Liu*. Novel selective κ agonists SLL-039 and SLL-1206 produce potent antinociception with fewer sedation and aversion. Acta Pharmacol Sin, 2022, 43(6):1372-1382. doi: 10.1038/s41401-021-00761-x.

5. Qian He, Yuanyuan Wei, Xiao Liu, Rongrong Ye, Linghui Kong, Zixiang Li, Shuang Jiang, Linqian Yu, Jingrui Chai, Qiong Xie, Wei Fu, Yujun Wang*, Wei Li*, Zhuibai Qiu, Jinggen Liu*, Liming Shao *. Discovery of an m‑substituted N‑cyclopropylmethyl-7α-phenyl-6,14-endoethanotetrahydronorthebaine as a selective, potent, and orally active κ‑opioid receptor agonist with an improved central nervous system safety profile. J Med Chem, 2021, 64(16), 12414–12433. https://doi.org/10.1021/acs.jmedchem.1c01082

6. Huoming Huang, Xueping Li, Peng Xie, Xinwei Li, XueJun Xu, Yuanyuan Qian, Congmin Yuan, Xiangguo Meng, JingRui Chai, Jing Chen, Jing Liu, Wenli Wang, Wei Li*, YuJun Wang*, Wei Fu*, Jinggen Liu. Discovery, Structure–Activity Relationship, and Mechanistic Studies of 1-((3R,4S)-3- ((Dimethylamino)methyl)-4-hydroxy-4-(3-methoxyphenyl)piperidin-1-yl)-2-(2,4,5-trifluorophenyl)ethan-1-one as a Novel Potent Analgesic. J Med Chem, 2021, 64(13), 9458–9483. https://doi.org/10.1021/acs.jmedchem.1c00722

Xiao Liu, Rongrong Ye, Linghui Kong, Shuang Jiang, Li Xiao, Xuejun Xu, Qian He, Yuanyuan Wei, Zixiang Li, Huijiao Sun, Qiong Xie, Xu Xu, Yan Lu, Yujun Wang*, Wei Li*, Wei Fu, Zhuibai Qiu, Jinggen Liu*, Liming Shao*. An Exploration of the SAR Connection Between Morphinan and Arylacetamide-based κ Opioid Receptor (κOR) Agonists using the Strategy of Bridging. ACS Chem NeuroSci, 2021, 12(6), 1018-1030. https://doi.org/10.1021/acschemneuro.1c00034

7. Huoming Huang, Wenli Wang, Xuejun Xu, Chen Zhu, Yujun Wang, Jinggen Liu*, Wei Li*, Wei Fu*. Discovery of 3-((dimethylamino)methyl)-4-hydroxy- 4-(3-methoxyphenyl)-N-phenylpiperidine-1-carboxamide as novel potent analgesic. Eur J Med Chem, 2020, 189: 112070-112084. doi: 10.1016/j.ejmech.2020.112070

8. Li Xiao, Yujun Wang, Mumei Zhang, Weiwei Wu, Linghui Kong, Yan Ma, Xuejun Xu, Xiao Liu, Qian He, Yuanyuan Qian, Huijiao Sun, Haihao Wu, Cheng Lin, Huoming Huang, Rongrong Ye, Shuang Jiang, Rufeng Ye, Congmin Yuan, Shengyang Fang, Dengqi Xue, Xicheng Yang, Hao Chen, Yilin Zheng, Linqian Yu, Qiong Xie, Lan Zheng, Wei Fu, Wei Li*, Zhuibai Qiu, Jinggen Liu *, Liming Shao*. Discovery of a highly selective and potent kappa opioid receptor agonist from N-cyclopropylmethyl-7α-phenyl- 6,14-endoethano-tetrahydro- northebaines with reduced central nervous system (CNS) side effects navigated by the message-address concept. J Med Chem 2019, 62(24): 11054-11070. 10.1021/acs.jmedchem.9b00857

9. Huijiao Sun, Yuhua Wang, Congmin Yuan, Linghui Kong, Xuejun Xu, Yujun Wang, Haihao Wu, Cheng Lin, Yuanyuan Qian, Huoming Huang, Li Xiao, Xiao Liu, Qian He, Shengyang Fang, Dengqi Xue, Xicheng Yanga, Hao Chen, Yilin Zheng, Lan Zheng, Linqian Yu, Qiong Xie, Wei Fu, Wei Li*, Jinggen Liu*, Zhuibai Qiu, Liming Shao*. 7β-methyl substituent is a structural locus associated with activity cliff for nepenthone analogues. Bioorg Med Chem, 2018, 26 (14), 4254-4263. https://doi.org/10.1016/j.bmc.2018.07.020

10. Wei Li#, Jiandong Long#, Yuanyuan Qian#, Yu Long, Xuejun Xu, Yujun Wang, Qing Shen, Zuoneng Wang, Xicheng Yang, Li Xiao, Hongpeng Sun, Yulong Xu, Yiyi Chen, Qiong Xie, Yonghui Wang, Liming Shao, Jinggen Liu*, Zhuibai Qiu, Wei Fu*. The Pharmacological Heterogeneity of Nepenthone Analogs in Conferring Highly Selective and Potent Kappa-Opioid Agonistic Activities. ACS Chem NeuroSci, 2017, 8 (4), 766–776. https://doi.org/10.1021/acschemneuro.6b00321