李炜

药物化学, 副教授, 硕士生导师

发布时间:2021-05-10浏览次数:345

姓      名

 李炜

性      别

 男

职      称

 副教授

学      历

 博士

电      话

 

传      真

 

电子邮件

 wei-li@fudan.edu.cn

个人主页

 

通讯地址

 上海市浦东新区张衡路826号复旦大学张江校区

 

教育经历
1998.9-2002.7  复旦大学药学院药学专业本科

2002.9–2004.7 复旦大学药学院药物化学教研室硕士研究生

2004.9-2007.7  复旦大学药学院药物化学教研室博士研究生


工作经历
2016.12 – 至今    复旦大学药学院,副教授

2012.10– 2013.10   哈佛医学院精神卫生中心药物化学实验室,访问学者

2007.7 – 2016.11   复旦大学药学院,讲师


研究方向
1.  镇痛药物与阿片受体配基的研究

2.  多样性化合物库的构建及其在中枢神经系统疾病治疗药物发现中的应用


代表性论著                                                   


1.   Qian He#, Yuanyuan Wei#, Xiao Liu #, Rongrong Ye, Linghui Kong, Zixiang Li, Shuang Jiang, Linqian Yu, Jingrui Chai, Qiong Xie, Wei Fu, Yujun Wang*, Wei Li*, Zhuibai Qiu, Jinggen Liu*, Liming Shao*. Discovery of an m‑substituted N‑cyclopropylmethyl-7α-phenyl-6,14-endoethanotetrahydronorthebaine as a selective, potent, and orally active κ‑opioid receptor agonist with an improved central nervous system safety profile. J Med Chem, 2021, 64(16), 12414–12433.

2.   Huoming Huang#, Xueping Li#, Peng Xie#, Xinwei Li#, XueJun Xu, Yuanyuan Qian, Congmin Yuan, Xiangguo Meng, JingRui Chai, Jing Chen, Jing Liu, Wenli Wang, Wei Li*, YuJun Wang*, Wei Fu*, and Jinggen Liu. Discovery, Structure–Activity Relationship, and Mechanistic Studies of 1-((3R,4S)-3-((Dimethylamino)methyl)-4-hydroxy-4-(3-methoxyphenyl)piperidin-1-yl)-2-(2,4,5-trifluorophenyl)ethan-1-one as a Novel Potent Analgesic. J Med Chem, 2021, 64(13), 9458–9483.

3.   Xiao Liu#, Rongrong Ye#, Linghui Kong#, Shuang Jiang#, Li Xiao, Xuejun Xu, Qian He, Yuanyuan Wei, Zixiang Li, Huijiao Sun, Qiong Xie, Xu Xu, Yan Lu, Yujun Wang*, Wei Li*, Wei Fu, Zhuibai Qiu, Jinggen Liu*, Liming Shao*. An Exploration of the SAR Connection Between Morphinan and Arylacetamide-based κ Opioid Receptor (κOR) Agonists using the Strategy of Bridging. ACS Chem NeuroSci, 2021, 12(6), 1018-1030.

4.   Huoming Huang, Xinwei Li, Wei Guo, Chen Zhu, Yuanyuan Qian, Qing Shen, Xuejun Xu, Wei Li, Yujun Wang*, Wei Fu*. Design, Synthesis, and Structure–Activity Relationship Exploration of Alkyl/Phenylalkyl Piperidine Analogues as Novel Highly Potent and Selective μ Opioid Receptor Agonists. ACS Chem NeuroSci, 2021, 12(2), 285–299.

5.  Bangyi Zhao#, Wei Li#Lijie Sun, Wei Fu*. The Use of Computational Approaches in the Discovery and Mechanism Study of Opioid Analgesics. Front Chem, 2020, 8: 335.

6.   Huoming Huang, Wenli Wanga, Xuejun Xu, Chen Zhu, Yujun Wang, Jinggen Liu*, Wei Li*, Wei Fu*. Discovery of 3-((dimethylamino)methyl)-4-hydroxy- 4-(3-methoxyphenyl)-N-phenylpiperidine-1-carboxamide as novel potent analgesic. Eur J Med Chem, 2020, 189: 112070-112084.

7.   Li Xiao# , Yujun Wang #, Mumei Zhang #, Weiwei Wu #, Linghui Kong, Yan Ma, Xuejun Xu, Xiao Liu, Qian He, Yuanyuan Qian, Huijiao Sun, Haihao Wu, Cheng Lin, Huoming Huang, Rongrong Ye, Shuang Jiang, Rufeng Ye, Congmin Yuan, Shengyang Fang, Dengqi Xue, Xicheng Yang, Hao Chen, Yilin Zheng, Linqian Yu, Qiong Xie, Lan Zheng, Wei Fu, Wei Li*, Zhuibai Qiu, Jinggen Liu *, Liming Shao*. Discovery of a highly selective and potent kappa opioid receptor agonist from N-cyclopropylmethyl-7α-phenyl-6,14-endoethano-tetrahydro- northebaines with reduced central nervous system (CNS) side effects navigated by the message-address concept. J Med Chem 2019, 62(24): 11054-11070.

8.   Xicheng Yang, Jian Shen, Lulu Jiang, Wei Li, Mingcheng Yu, Guanxing Pan, Yurong Yan, Chenghan Zhang, Wanwan Jia, Li Xiao, Haihua Yu, Hao Chen, Yilin Zheng, Linqian Yu, Qiong Xie*, Lu Zhou*, Liming Shao*. Discovery, cocrystallization and biological evaluation of novel piperidine derivatives as high affinity Ls-AChBP ligands possessing alpha-7 nAChR activities. Eur J Med Chem, 2018, 160, 37-48.

9.   Huijiao Sun#, Yuhua Wang#, Congmin Yuan#, Linghui Kong, Xuejun Xu, Yujun Wang, Haihao Wu, Cheng Lin, Yuanyuan Qian, Huoming Huang, Li Xiao, Xiao Liu, Qian He, Shengyang Fang, Dengqi Xue, Xicheng Yanga, Hao Chen, Yilin Zheng, Lan Zheng, Linqian Yu, Qiong Xie, Wei Fu, Wei Li*, Jinggen Liu*, Zhuibai Qiu, Liming Shao*. 7β-methyl substituent is a structural locus associated with activity cliff for nepenthone analogues. Bioorg Med Chem, 2018, 26 (14), 4254-4263.

10. Wei Li#, Jiandong Long#, Yuanyuan Qian#, Yu Long, Xuejun Xu, Yujun Wang, Qing Shen, Zuoneng Wang, Xicheng Yang, Li Xiao, Hongpeng Sun, Yulong Xu, Yiyi Chen, Qiong Xie, Yonghui Wang, Liming Shao, Jinggen Liu*, Zhuibai Qiu, Wei Fu*. The Pharmacological Heterogeneity of Nepenthone Analogs in Conferring Highly Selective and Potent κ-Opioid Agonistic Activities. ACS Chem NeuroSci, 2017, 8 (4), 766–776.

11. Jian Shen#, Xicheng Yang#, Mingcheng Yu, Li Xiao, Xunjie Zhang, Huijiao Sun, Hao Chen, Guanxin Pan, Yurong Yan, Sichen Wang, Wei Li*, Lu Zhou*, Qiong Xie, Linqian Yu, Yonghui Wang, Liming Shao*. Discovery, synthesis, biological evaluation and structure-based optimization of novel piperidine derivatives as acetylcholine-binding protein ligands. Acta Pharmacol Sin 2017, 38(1): 146-155.

12.  Qing Shen, Yuanyuan Qian, Xiaoqin Huang, Xuejun Xu, Wei Li*, Jinggen Liu*, Wei Fu*. Discovery of Potent and Selective Agonists of δ Opioid Receptor by Revisiting the “Message-Address” Concept. ACS Med Chem Lett, 2016, 7 (4), 391–396.

联系我们
地址:上海浦东新区张衡路826号
电话:(021)51980001
邮编:201203