左中，香港中文大学药剂学院教授。1998年获加拿大阿尔伯塔大学药学博士，拥有多年药物生物药剂学与药代动力学领域研究经验，作为PI获得了大学资助局、创新科技基金、食物及卫生局、香港特别行政区医院管理局等机构逾2400万元持续支持，发表高质量的研究论文和会议文章超过300篇，并在美国、中国和马来西亚等地获得4项专利，相关研究成果已应用于改进西药和草药产品的质量控制、递送、阐明甚至预测体内潜在的草药/药物相互作用等领域。

教育经历

1986.09 – 1991.07 四川大学华西药学院，药学专业，学士

1993.09 – 1998.08 加拿大阿尔伯塔大学药学院，药学科学专业，博士（导师：Leonard Wiebe）

工作经历

2000.01 – 至今 香港中文大学医学院药学院

1997.09 – 1999.12 加拿大NAEJA制药公司，生物药剂学与药代动力学部，科学家

1994.01 – 1997.09 加拿大阿尔伯塔大学药学院，助教

1991.08 – 1992.12 西安杨森制药有限公司（中国），运营部，工业药剂师

研究方向

1.新型药物及草药活性成分的生物药剂学与药代动力学

2.聚焦药物递送系统（舌下/鼻腔给药）及体内代谢机制

3.草药-药物相互作用的临床前/临床及AI辅助研究

4.结合AI文献挖掘、动物模型和临床试验评价相互作用机制

5.代谢性疾病与肠道菌群的调控机制

6.探索中药多糖（如铁皮石斛、黄芪）通过肠道菌群改善糖尿病的药效学

专业学会任职

1.美国药学科学家协会会士 (Fellow)

2.国际外源化合物研究学会会员 (Member)

3.美国药学科学家协会会员 (Member)

4.世界中医药学会联合会执行理事 (Executive Council Member)

5.香港学者协会主席 (President, Hong Kong SAR)

代表性论著

1.Hung KKC, Lam RPK, Lee HKH, Choi YF, Tenney J, Zuo Z, Chong MKC, Hui TS, Wong TK, Yiu TY, Chan SY, Mok CPY, Leung LY, Mak WK, Sun DTF, Cheng CH, Graham C. Comparison of diclofenac with tramadol, tizanidine or placebo in the treatment of acute low back pain and sciatica: multi-center randomized controlled trial. Postgraduate Medical Journal 2024, DOI10.1093/postmj/qgae052. (IF: 3.6, Q1, JCI Rank 70/329 in Medicine, General & Internal).

2.Zou JJ, Song QB, Shaw PC, Zuo Z*. Dendrobium officinale regulate lipid metabolism in diabetic mouse liver via PPAR-RXR signaling pathway: Evidence from an integrated multi-omics analysis. Biomedicine & Pharmacotherapy 2024, 173: 116395. DOI10.1016/j.biopha.2024.116395 (IF: 6.9, Q1, JCI Rank 25/354 in Pharmacology & Pharmacy).

3.Xie HL, Zhang AL, Li JW, Mou X, He T, Yeung TC, Lau CBS, Zuo Z, Li P, Kennelly EJ, Leung PC, Tang Y, Fan XH, Wang CC, Li L. Cycasin derivative: a potential embryotoxic component of Atractylodes macrocephala rhizome for limb malformation. Toxicology Research 2024, 13(2). DOI10.1093/toxres/tfae057. (IF: 2.2, Q3, JCI Rank 77/106 in Toxicology).

4.Fong W, Li Q, Ji FF, Liang W, Lau HCH, Kang X, Liu WX, To KKW, Zuo Z, Li XX, Zhang X, Sung JJY, Yu, J. Lactobacillus gallinarum-derived metabolites boost anti-PD1 efficacy in colorectal cancer by inhibiting regulatory T cells through modulating IDO1/Kyn/AHR axis. GUT 2023, 721(12):2272-2285. DOI10.1136/gutjnl-2023-329543. (IF: 23, Q1, JCI Rank 4/143 in Gastroenterology & Hepatology).

5.Scheeff S, Wang Y, Lyu MY, Nasiri Ahmadabadi B, Hau S, Hui T, Zhang YF, Zuo Z, Chan RWY, Ng BWL. Design and Synthesis of Bicyclo-[4.3.0]-nonene Nucleoside Analogues. Organic Letters 2023,  DOI:10.1021/acs.orglett.3c03590. (IF: 5.2, Q1, JCI Rank 3/58 in Chemistry, Organic).

6.Song QB, Cheng SW, Zou JJ, Li KSL, Cheng HY, Song QB, Cheng SW, Zou JJ, Li KSL, Cheng HY, Lau DTW, Han QB, Yang X, Shaw PC, Zuo Z*. Role of gut microbiota on regulation potential of Dendrobium officinale Kimura & Migo in metabolic syndrome: In-vitro fermentation screening and in-vivo verification in db/db mice. J Ethnopharmacol. 2023, DOI: 10.1016/j.jep.2023.117437. (IF: 5.4, Q1, JCI Rank 4/42 in Integrative & Complimentary Medicine).

7.Zhang J, Zhang YF, Lai YS, Song QB, Xiao M, Ji XY, Yan XY, Zuo Z*. Elucidation of Carboxylesterase Mediated Pharmacokinetic Interactions between Irinotecan and Oroxylin A in Rats via Physiologically Based Pharmacokinetic Modeling. Pharm. Research 2023, https://doi.org/10.1007/s11095-023-03590-1. (IF: 3.7, Q2, JCI Rank 69/230 in Chemistry, Multidisciplinary).

8.Scheeff S, Wang Y, Lyu MY, Ahmadabadi BN, Hau SCK, Hui TK, Zhang YF, Zuo Z, Chan RWY, Ng BWL. Diversification of Nucleoside Analogues as Potent Antiviral Drug Leads. bioRxiv 2023, DOI: 10.1101/2023.06.17.545395

9.Huang QH, Zhang J, Cho WCS, Huang Y, Yang W, Zuo Z, Xian YF, Lin ZX. Brusatol suppresses the tumor growth and metastasis of colorectal cancer via upregulating ARRDC4 expression through modulating PI3K/YAP1/TAZ Pathway. Phytomedicine, 2023, 109:154567. DOI: 10.1016/j.phymed.2022.154567. (IF: 7.9, Q1, JCI Rank 1/42 in Integrative & Complimentary Medicine).

10.Ji X., Yang M., Shen G., Or K.H., Yim W.S., Zuo Z*. Safety evaluations of the processed lateral root of Aconitum carmichaelii Debx. and its hepatotoxicity mechanisms in rats. J Ethnopharmacol. 2023, 301:115801. (IF: 5.4, Q1, JCI Rank 4/42 in Integrative & Complimentary Medicine).