丁宁

副教授

发布时间:2021-04-22阅读次数:19

丁 宁,药物化学,副教授,博士生导师

个人信息:

复旦大学药学院药物化学教研室

复旦大学张江校区化学南楼405

上海市张衡路826号,201203

电话:021-51980165

 E-mail: dingning@fudan.edu.cn

丁宁博士课题组的主要研究方向为糖类药物化学。发表SCI收录学术论文60余篇。研究工作获国家新药创制重大专项、国家自然科学基金、上海市人才发展基金、上海市生物医药专项等十余项国家、省部级课题的资助。主讲本科生课程《药物化学》(上海市精品课程/上海市教委本科重点课程/复旦大学精品课程)、《化学生物学导论》部分章节并带教《有机化学实验》等;主讲研究生课程《糖化学》及《高等药物化学》部分章节等。现任中国生物物理学会糖生物学分会第一届理事(2021-);Chin. Chem. Lett.第一届通讯编委会委员。

主要研究方向:

糖类药物化学

教育经历:

2004 – 2007,中国海洋大学医药学院,教育部海洋药物重点实验室,博士

2001 – 2004,中国海洋大学医药学院,教育部海洋药物重点实验室,硕士

1997 – 2001,中国海洋大学水产学院,药物化学专业,学士

工作经历:

2013 – 今,复旦大学药学院药物化学系,副教授

(其中:2014 – 2016,佐治亚大学复杂碳水化合物研究中心,访问学者)

2009 – 2012,复旦大学药学院药物化学系,讲师

2007 – 2008,普度大学化学系,博士后



主持科研项目情况:

  1. 国家自然科学基金面上项目(22077017)。

  2. 新药创制重大专项(任务2018ZX09711002-006-008)。

  3. 上海市科委“科技创新行动计划”生物医药领域科技支撑项目(17431902400)。

  4. 上海市人才发展资金(2017年度)。

  5. 国家自然科学基金青年项目(21002014)。

  6. 中科院上海药物所新药研究国家重点实验室开放课题(SIMM0812KF-08 & SIMM1403KF-08)。

  7. 教育部留学回国人员科研启动基金(第41-1)。

  8. 教育部博士点新教师基金(20100071120051)。

  9. 复旦大学新教师科研启动基金(10FX061)。



获奖及荣誉:

2018年复旦大学德传奖教金

2017年上海市人才发展资金(上海市人力资源与社会保障局)

2013 年复旦大学第一三共制药奖教金

2013 年复旦大学青年教师讲课比赛(医科组)二等奖

2012年复旦大学优秀青年人才项目“卓学计划”(2012-2014)。

2012年复旦大学药学院青年教师讲课比赛一等奖。


近期代表性论著:

  1. Yu-Long He, Meng-Ting Chen, Ting Wang, Ming-Ming Zhang, Ying-Xia Li*, He-Yao Wang*, Ning Ding*. Development of FABP4/5 inhibitors with potential therapeutic effect on type 2 diabetes mellitus. European Journal of Medicinal Chemistry, 2021, 224, 11370 (https://doi.org/10.1016/j.ejmech.2021.113720).

  2. Sumei Ren, Minmin Zhang, Yujie Wang, Jia Guo, Junfei Wang, Yingxia Li, Ning Ding*. Synthesis and biological evaluation of novel Cabazitaxel analogues. Bioorganic & Medicinal Chemistry, 2021, 41, 116224 (https://doi.org/10.1016/j.bmc.2021.116224).

  3. Lei Li, Haisheng He, Sifang Jiang, Jianping Qi, Yi Lu, Hai-shu Lin, Ning Ding, Wei Wu*, Xiaoqiang Xiang*. Simulation of the in vivo fate of polymeric nanoparticles traced by environment-responsive near-infrared dye: A physiologically based pharmacokinetic modelling approach. Molecules, 2021, 26, 1271 (https://doi.org/10.3390/molecules26051271) .

  4. Yang Zhang, Jia Guo, Xiaoyan Xu, Qi Gao, Xianglai Liu, and Ning Ding*. A practical and scalable synthesis of KRN7000 by using of glycosyl iodide as the glycosyl donor. Journal of Chemical Research, 2021, 248-252 (https://doi.org/10.1177/1747519820961018).

  5. Ke Xu#, Qingmin Man#, Yang Zhang, Jia Guo, Yichu Liu, Zunyun Fu, Yueyue Zhu, Yingxia Li, Mingyue Zheng*, Ning Ding*. Investigation of the remote acyl group participation in glycosylation from conformational perspectives by using trichloroacetimidate as the acetyl surrogate. Organic Chemistry Frontiers, 2020,7, 1606-1615 (DOI: 10.1039/d0qo00363h).

  6. Shiqiang Yan#, Yueyue Zhu#, Yujie Wang, Qiang Xiao, Ning Ding*, Yingxia Li*. Total synthesis of leontopodioside A. Tetrahedron Letters, 2020, https://doi.org/10.1016/j.tetlet.2020.151886.

  7. Xiying Wu, Hongmin Zhang, Shuhua He, Qin Yu, Yi Lu, Wei Wu, Ning Ding, Quangang Zhu, Zhongjian Chen, Yuhua Ma, Jianping Qi*. Improving dermal delivery of hyaluronic acid by ionic liquids for attenuating skin dehydration. International Journal of Biological Macromolecules, 2020, 150, 528–535 (https://doi.org/10.1016/j.ijbiomac.2020.02.072).

  8. Shiqiang Yan, Mingxian Xie, Yujie Wang, Qiang Xiao, Ning Ding*, Yingxia Li*. Semi-synthesis of a series natural flavonoids and flavonoid glycosides from scutellarin. Tetrahedron, 2020, https://doi.org/10.1016/j.tet.2020.130950.

  9. Sumei Ren, Ruiqi Liu, Yujie Wang, Ning Ding*, Yingxia Li*. Synthesis and biological evaluation of Ginsenoside compound K analogues as a novel class of anti-asthmatic agents. Bioorganic & Medicinal Chemistry Letters, 2019, 29, 51-55 (https://doi.org/10.1016/j.bmcl.2018.11.016).

  10. Xianglai Liu#, Sumei Ren#,Qi Gao, Chun Hu*,Yingxia Li, and Ning Ding*.  Glycosylation of a ketone with an O-glycosyl trichloroacetimidate provides an enol glycoside. Organic Letters2018, 20, 5186-5189 (https://doi.org/10.1021/acs.orglett.8b02126).

  11. Sumei Ren, Yujie Wang, Junfei Wang, Dingding Gao, Minmin Zhang, Ning Ding*, Yingxia Li*. Synthesis and biological evaluation of novel larotaxel analogues. European Journal of Medicinal Chemistry2018, 156, 692-710 (https://doi.org/10.1016/j.ejmech.2018.07.029).

  12. Ting Wang, Jianping Qi, Ning Ding, Xiaochun Dong, Weili Zhao, Yi Lu, Changhong Wang*, Wei Wu*. Tracking translocation of self-discriminating curcumin hybrid nanocrystals following intravenous delivery. International Journal of Pharmaceutics2018, 546, 10-19 (https://doi.org/10.1016/j.ijpharm.2018.05.020).

  13. Qi Yan, Yuzhe Chen, Baiyou Tang, Qiang Xiao, Rong Qu, Linjiang Tong, Jian Liu, Jian Ding, Yi Chen, Ning Ding, Wenfu Tan*, Hua Xie*, Yingxia Li*. Discovery of novel 2,4-diarylaminopyrimidine derivatives as potent and selective epidermal growth factor receptor (EGFR) inhibitors against L858R/T790M resistance mutation. European Journal of Medicinal Chemistry2018, 152, 298-306 (https://doi.org/10.1016/j.ejmech.2018.04.052).

  14. Shiqiang Yan, Sumei Ren, Ning Ding, Yingxia Li*. Concise total synthesis of acylated phenolic glycosides vitexnegheteroin A and ovatoside D. Carbohydrate Research2018, 460, 41-46 (https://doi.org/10.1016/j.carres.2018.02.015).

  15. Ning Ding, Xiuru Li, Zoeisha S. Chinoy, Geert-Jan Boons*. Synthesis of a glycosylphosphatidylinositol anchor derived from Leishmania donovani that can be functionalized by Cu-catalyzed azide-alkyne cycloadditions. Organic Letters 2017, 19, 3827−3830 (https://doi.org/10.1021/acs.orglett.7b01703).

  16. Dongming Yao#, Yichu Liu#, Qi Gao, Qiang Sui, Xiaoping Liu*, Ning Ding*. A comparison of benzyl and 2-naphthylmethyl ethers as permanent hydroxyl protecting groups in the synthesis of alpha-galactoglycosphingolipids KRN7000 and PBS-57. Journal of Carbohydrate Chemistry2017, 36, 173-188 (https://doi.org/10.1080/07328303.2017.1375114).

  17. Dongming Yao#, Yichu Liu#, Shiqiang Yan, Yingxia Li, Chun Hu, Ning Ding*. Evidence of robust participation by an equatorial 4-O group in glycosylation on a 2-azido-2-deoxy-glucopyranosyl donor. Chemical Communications2017, 53, 2986-2989 (https://doi.org/10.1039/C7CC00274B).

  18. Yichu Liu, Xiaoyan Xu, Qi Gao, Shiqiang Yan, Yingxia Li, Ning Ding*. Rapid access to 6”-functionalized alfa-galactosyl ceramides by using 2-naphthylmethyl ether as the permanent protecting group. Bioorganic & Medicinal Chemistry Letters2017, 27, 1795-1798 (https://doi.org/10.1016/j.bmcl.2017.02.055).