郁韵秋

发布时间:2023-09-14浏览次数:420


教育经历

1979.09 – 1983.08 华东师范大学化学系(本科)

1983.09 – 1986.06 华东师范大学化学系(研究生)

 

工作经历

1986.07 – 1988.09 上海医科大学药学院,助教

1988.10 – 1994.09 上海医科大学药学院,讲师

1994.10 – 2011.08 复旦大学药学院,副教授

2011.09 – 至今 复旦大学药学院,教授

1997.09  - 1998.03 日本长崎大学药学部进修

 

主要科研贡献

3.建立了多种体内药物浓度的测定方法,药物涉及多种类别,包括小分子蛋白(多肽)药物的测定,比如建立了测定人血中和尿中重组双功能水蛭素方法,该方法具有准确、灵敏,选择性好,血浆用量少等优点,成功应用于该药物的临床试验和研究。

4.开展了多个药物的质量标准研究,在此过程中,通过定性定量分析为合成工艺的改进提供了非常重要的帮助,为药品的质量控制提供了合理有用的方法。

5.近年来开始进入疾病的代谢组学研究领域,目前运用代谢组学方法对CTCL生物标志物进行研究、已经筛寻得到数十个潜在的生物标志物。 通过代谢组学的研究将为疾病的诊断提供依据,进一步可展望靶点药物研发。

6.发表论文50余篇,申请专利6项(获得授权4项)。

7.培养的博士生2人; 培养硕士生15人,获得上海市优秀硕士毕业论文1人,上海市优秀硕士毕业生1人。

 

承担科研项目情况

国家自然科学基金面上项目:木鳖子抗肿瘤药效的物质基础研究(NSFC  C190703);基于LC-MS技术的CTCL生物标志物的发现及其生物学意义研究(NSFC  81272988)

上海市自然科学基金项目:霉酚酸酯药动学与器官移植存活率相关性研究(03ZR14010)

 

获奖及荣誉

2009.11  上海市科技进步三等奖

2009.12 上海市研究生优秀成果(学位论文),导师

2011.05  上海市优秀发明选拔赛优秀发明银奖

 

研究方向

1.新药质量标准的建立

2.体内药物分析方法研究

3.代谢组学研究

 

代表性论著

1.Xia Li, Yu Wang, Qingyuan Zhou, Yunqiu Yu*, Lihong Chen, Jie Zheng, A sensitive method for digoxin determination using formate-adduct ion based on the effect of ionization enhancement in liquid chromatograph-mass spectrometer, Journal of Chromatography B[J], 2015, 978–979: 138-44.  

2.Qing-Yuan Zhou, Yue-Lin Wang, Xia Li, Xiao-Yan Shen, Ke-Jia Li, Jie Zheng, Yun-Qiu Yu*, Metabolics Investigation of Cutaneous T Cell Lymphpma Based on UHPLC-QTOF/MS. Asian Pacific journal of cancer prevention[J]. 2014;15(13):5417-21.

3.Xiaoyun Liu, Shuiqing Zheng, Zheng Jiang, Chen Liang, Rong Wang, Zhe Zhou, Yurong Zhang, Yunqiu Yu*, Rapid separation and identification of Strychnos alkaloids metabolites in rats by ultra high performance liquid chromatography with linear ion trap Orbitrap mass spectrometry Journal of Separation Science  2014(37),764–774

4.Qixin Dong,Jiajun Zhu,Qiang Sui,Chao Tang,Xiaomei Wang,Yunqiu Yu*,Optimization of mobile phase for the determination of Esomeprazole and related compounds and investigation of stress degradation by LC–MS  Journal of Separation Science  2013(36),1200–1208

5.Zhuhong Yu,  Zhongping Wu,  Feijun Gong,  Rong Wong,  Chen Liang,  Yurong Zhang*,  Yunqiu Yu*   Simultaneous determination of six toxic alkaloids in human plasma and urine using capillary zone electrophoresis coupled to time-of-flight mass spectrometry   Journal of Separation Science   2012, 35(20), 2773–2780  ISSN 1615-9314

6.Zhi-Yan Lin, Xiaoyun Liu, Fan Yang, Yun-Qiu Yu,  Structural characterization and identification of five triterpenoid saponins isolated from Momordica cochinchinensis extracts by liquid chromatography/tandem mass spectrometry International Journal of Mass Spectrometry  328–329 (2012) , 43–66 ISSN 1387-3806

7.Le Pan, Yunqiu Yu*, Longwei Sun, An LC–MS Method for a Hexokinase Inhibitor Study Based on Adenosine 50-Triphosphate Determination and Application to the Anticancer Mechanism of Momordica cochinchinensis, Chromatographia,  2010  (72)  425-430  ISSN 0009-5893(print) 1612-1112(online)

8.Le Pan, Yanping Guo, Zhongdong Li, Jun Chen, Tian Jiang, Yunqiu Yu*, Longwei Sun,Simultaneous Determination of Levodopa, Benserazide and 3-O-Methyldopa in Human Serum by LC–MS–MS,Chromatographia, 2010  (72)  627-633   ISSN 0009-5893(print) 1612-1112(online)

9.Shengmin Su, Yunqiu Yu*, Online preconcentration of recombinant Arg-Gly-Asp-hirudin using dynamic pH junction for analysis in human urine samples by capillary electrophoresis-mass spectrometry. Journal of Chromatography A, 2009, (1216) 1490–1495 ISSN 0021-9673

10.Shengmin Su, Yunqiu Yu, Wei Mob, Yanling Zhang, Houyan Song, Qinfen Chen, Yi Xie,A development of LC–MS method combining ultrafiltration and lyophilization for determination of r-RGD-Hirudin in human serum Journal of Chromatography B,2008,870 27-31  ISSN 1570-0232


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