Dr.Bin Lou obtained his Ph.D from University of Fudan in 2000. She worked at Ddepartment of Pharmacology and Biochemistry ,School of Pharmacy, Fudan University since 1989 to present.She specializes in the machenism of atherosclerosis and small molecular in cells.
Lipid metabolism; Atherosclerosis; Inflammation
Education
2005 Ph.D., Biochemistry and molecular Biology, Fudan University
1989 M.S. Radiopharmacy, Fudan University
1983 B.S. Medicinal chemistry,School of Pharmacy, Fudan University
Professional Experiences
1998- Present Associate Professor, Department of Biochemistry School of Pharmacy, Fudan University, Shanghai
1989-1998 Instructor, Department of Biochemistry, School of Pharmacy,Fudan University, Shanghai
Teaching Activities
undergraduate courses: Biochemistry , Molecular Biology
Graduate courses: Advanced Biochemistry in Pharmaceutical studies.
Selected Publications（latest 5 yrs，<20 papers）
1. Yali Li, Taomin Huang, Bin Lou, Deyong Ye, Xiangyu Qi, Xiaoxia Li, Shuang Hu, Tingbo Ding, Yan Chen, Yang Cao, Mingguang Mo, Jibin Dong, Min Wei, Yong Chu, Huiti Li, Xian-Cheng Jiang, Nengneng Cheng a, Lu Zhou. Discovery, synthesis and anti-atherosclerotic activities of a novel selective sphingomyelin synthase 2 inhibitor. Eur J Med Chem. 1;163: 864-882, 2019
2. Bin Lou, Qi Liu Jiahui Hou, Inamul Kabir, Peipei Liu, Tingbo Ding, Jibin Dong, Mingguang Mo, Deyong Ye, Yang Chen, Hai H. Bui, Kenneth Roth, Yu Cao, Xian-Cheng Jiang. 2-Hydroxy-oleic acid does not activate sphingomyelin synthase activity. J Biol Chem. 293(47):18328-18336, 2018
3. Chunyan Feng, Bin Lou, Jibin Dong, Zhiqiang Lib, Yunqin Chen, Yue Li, Xuemei Zhang, Xian-Cheng Jiang, Tingbo Ding. Lysophosphatidylcholine acyltransferase 3 de?ciency impairs 3T3L1 cell adipogenesis through activating Wnt/β-catenin pathway.BBA - Molecular and Cell Biology of Lipids 1863: 834–843,2018
4. Hui Jiang,Amirfarbod Yazdanyar, Bin Lou, Yunqin Chen, Xiaomin Zhao, Ruohan Li, Hai Hoang Bui, Ming-Shang Kuo, Mohamad Navab, Shucun Qin, Zhiqiang Li, Weijun Jin, Xian-Cheng Jiang. Adipocyte Phospholipid Transfer Protein and Lipoprotein Metabolism. Arteriosclerosis, Thrombosis, and Vascular Biology.;35:316–322,2015
5. Adipocyte Phospholipid Transfer Protein and Lipoprotein Metabolism. Hui Jiang, Amirfarbod Yazdanyar, Bin Lou, Yunqin Chen, Xiaomin Zhao,Ruohan Li, Hai Bui, Ming-Shang Kuo, Mohamad Navab, Shucun Qin,Zhiqiang Li, Weijun Jin, and Xian-Cheng Jiang. Arterioscler Thromb Vasc Biol. 2015 Feb; 35(2): 316–322.
6.Bin Lou., Jibin Dong., Yali Li, Tingbo Ding, Tingting Bi, Yue Li, Xiaodong Deng, Deyong Ye, Xian-Cheng Jiang.Pharmacologic Inhibition of Sphingomyelin Synthase(SMS) Activity Reduces Apolipoprotein-B Secretion from Hepatocytes and Attenuates Endotoxin-Mediated Macrophage Inflammation. PLoS ONE 9(7): e102641，2014
7.Xiaodong Deng, Fu Lin, Ya Zhang, Yan Li, Lu Zhou, Bin Lou, Yue Li, Jibin Dong, Tingbo Ding， Xiancheng Jiang, Renxiao Wang,Deyong Ye. Identification of small molecule sphingomyelin synthase inhibitors. European Journal of Medicinal Chemistry,73（12）,1-7,2014
8.Tingbo Ding, Jibin Dong, Bin Lou, XianCheng Jiang. Sphingomyelin synthase activity measurement by the fluorescent product in cell culture medium or animal plasma. J. Chin. Pharm. Sci.2014,23(4),256–261
9.Yuhong Du, Robert W. Fu,Bin Lou,Jing Zhao,Min Qui, Fadlo R. Khuri, and Haian Fu.A Time-Resolved Fluorescence Resonance EnergyTransfer Assay for High-Throughput Screening. ASSAY and Drug Development Technologies .11(6),367-381, 2013.
10. Jing Zhao, Yuhong Du, John Horton, Anup Upadhyay, Bin Lou, Xing Zhang, Lupei Du, Minyong Li, Binghe Wang, Lixin Zhang, Joseph Barbieri, Fadlo Khuri, Xiaodong Cheng, and Haian Fu. Discovery and structural characterization of a small molecule 14-3-3 protein-protein interaction inhibitor. PNAS 108 (39)16212–16216, 2011.
