Deyong YE Professor of Medicinal Chemistry. Ye studied medicinal chemistry in Shanghai Medical University and obtained his master degree in 1987. He was employed in Shanghai Medical University (which was merged with Fudan University) as lecturer, associate professor and professor. His research field is rational design, synthesis and bioassay of small molecular drugs, especially the novel bioactive molecules aimed at potential novel targets, such as SMS (sphingomyelin synthase), GSK-3β (glycogen synthase-3β), NS5B (non-structural protein RNA-dependent RNA polymerase) and PGAM1 (phosphoglycerate mutase-1).
Computer modeling of the 3D structure of sphingomyelin synthase (SMS) , design and synthesis of SMS inhibitors, bioassessment of anti-apoptosis activities;
Design and synthesis of non ATP competitive glycogen synthase-3 beta (GSK-3β) inhibitors;
Design and synthesis of anti-HCV agents
Education
BS, School of Pharmacy, Shanghai Medical University;
MS, School of Graduate Studies, Shanghai Medical University
Professional Experiences
Teaching assistant, School of TCM, Shanghai University of TCM;
Lecturer, Associate professor and Professor, School of Pharmacy, Fudan University;
Teaching Activities
Organic Chemistry; Medicinal Chemistry; Drug Designology;
Molecular Methods and Technologies in Organic Synthesis.
Awards & Honors
National Teaching Achievement Award (1999);
Shanghai Teaching Achievement Award (1999);
Shanghai Municipal Teaching Award (2001);
Teaching Master of Fudan University (2008)
Memberships
Council member of Shanghai Pharmaceutical Association;
Deputy director of the Medicinal Chemistry committee, Shanghai Pharmaceutical Association;
Member of the National Assessment Committee of Pharmaceutical Education.
Invited Presentations
Plenary lecture, the Discovery of the First-class Inhibitors of Sphingomyelin Synthase, 2014 Queenstown Molecular Biology Meetings in Shanghai, March 14, 2014
Selected Publications
1. Yang Gao, De-Yong Ye*, Wei-Cheng Zhou*, Yong Chu*.The discovery of novel benzothiazinones as highly selective non-ATP competitive glycogen synthase kinase 3β inhibitors for the treatment of ovarian cancer. Eur. J. Med. Chem., 135, 370-381, 2017
2. Qi, X-Y., Cao, Y., Li, Y-L., Mo, M-G., Zhou, L., Ye, D-Y.*, Discovery of the selective sphingomyelin synthase 2 inhibitors with the novel structure of oxazolopyridine, Bioorg Med. Chem. Lett. 27, 3511–3515, 2017
3. Haojun Gong, Lu Zhou*, Deyong Ye*, Xing Gao, Yali Li, Xiangyu Qi and Yong Chu. Novel Dual Inhibitors of Secretory Phospholipase A2 and Sphingomyelin Synthase: Design, Synthesis and Evaluation. Lett. Drug Des. Discov. 13, 1-8, 2016
4. Ya-li Li, Xiang-yu Qi, Hui Jiang, Xiao-dong Deng, Yan-ping Dong, Ting-bo Ding, Lu Zhou Peng Men, Yong Chu, Ren-xiao Wang*, Xian-cheng Jiang*, De-yong Ye*. Discovery, synthesis and biological evaluation of 2-(4-(Nphenethylsulfamoyl)phenoxy)acetamides (SAPAs) as novelsphingomyelin synthase 1 inhibitors. Bioor.Med. Chem. 23: 6173-6184, 2015
5. Dongwei Zhong, Mingming Liu, Yang Cao, Yelin Zhu, Shihui Bian, Jiayi Zhou, Fengjie Wu, Kum-Chol Ryu, Lu Zhou,* and Deyong Ye*. Discovery of Metal Ions Chelator Quercetin Derivatives with Potent Anti-HCV Activities. Molecules. 20: 6978-6999, 2015
6. Xiaodong Deng, Fu Lin, Ya Zhang, Yan Li, Lu Zhou, Bin Lou, Yue Li, Jibin Dong, Tingbo Ding, Xiancheng Jiang, Renxiao Wang*, Deyong Ye* ,Identification of Small Molecule Sphingomyelin synthase inhibitors, Eur. J. Med. Chem. 73:1-7, 2014
7. Bin Lou*, Jibin Dong, Yali Li, Tingbo Ding, Tingting Bi, Yue Li, Xiaodong Deng, Deyong Ye*, Xian-Cheng Jiang. Pharmacologic Inhibition of Sphingomyelin Synthase (SMS) Activity Reduces Apolipoprotein-B Secretion from Hepatocytes and Attenuates Endotoxin-Mediated Macrophage Inflammation. PLoS ONE 9(7): 1-7, 2014
8. Huang T, Li X, Hu S, Zhao B, Chen P, Liu X, Ye D, Cheng N. Analysis of Fluorescent Ceramide and Sphingomyelin Analogs: A Novel Approach for in Vivo Monitoring of Sphingomyelin Synthase Activity. Lipids, 1-9, 2014
9. Peng Zhang, Shufen Li, Yang Gao, Wenbo Lu, Ke Huang, De-Yong Ye, Xi Li*,Yong Chu*, Novel Benzothiazinones (BTOs) as Allosteric Modulator or Substrate Competitive Inhibitor of Glycogen Synthase Kinase 3β (GSK-3β) with Cellular Activity of Promoting Glucose Uptake. Bioorg. Med. Chem. Lett.，24(24):5639-43, 2014
10. Peng Zhang, Hai-Rong Hu, Shi-Hui Bian, Zhao-Hui Huang , Yong Chu*, De-Yong Ye*, Design, synthesis and biological evaluation of benzothiazepinones (BTZs) as novel non-ATP competitive inhibitors of glycogen synthase kinase-3β(GSK-3β), Eur. J. Med. Chem., 65, 95-103, 2013
11. Gao Xing, Gong Haojun, Men Peng, Zhou Lu*, Ye Deyong*, Design, synthesis, and biological evaluation of novel dual in-hibitors of secretory phospholipase A2 and sphingomyelin synthase, Chin. J. Chem., 31(9): 1164–1170, 2013
12. Wu-Hui Song?, Ming-Ming Liu?, Dong-Wei Zhong, Ye-lin Zhu, Mike Bosscher, Lu Zhou*, De-Yong Ye*, Zheng-Hong Yuan*, Tetrazole and triazole as bioisosteres of carboxylic acid: Discovery of diketo tetrazoles and diketo triazoles as anti-HCV agents, Bioorg. Med. Chem. Lett., 23(16): 4528-4531, 2013
