程志红天然药物学系,教授,博士生导师,硕士生导师
姓名:程志红
职称:教授
电子邮件:chengzhh@fudan.edu.cn
电话:021-51980137
学历:博士
通讯地址:浦东张衡路826号复旦大学药学院
个人主页:

教育经历

1998.09 – 2003.06 中国药科大学中药学院,生药学博士
1994.09 – 1998.06 中国药科大学中药学院,中药分析学学士

 

工作经历

2018.12 -- 今 复旦大学药学院,教授

2009.01 – 2018.12 复旦大学药学院,副研究员

2005.10 – 2008.08 美国马里兰大学(University of Maryland at College Park),博士后
2003.07 – 2005.09 中科院上海有机化学研究所,博士后


社会任职

2020.08-  上海市药学会生药学专业委员会副主任委员  

2020.12-  上海市药学会第12届理事会理事

2020.06-今   中国康复医学会中药学与康复专业委员会第一届委员会常务委员 

2015.12-  SCI收录期刊《Current Analytical Chemistry》编委


获奖及荣誉

2011.01 教育部自然科学二等奖-麦冬类中药的系统研究(第三完成人)


承担科研项目情况

1. 国家自然科学基金面上项目:基于薄层自显影谱效关系-生物定量法的板蓝根抗流感病毒活性成分辨识与质量控制研究(82173967, 2022.01-2025.12;

2. 上海市科委自然科学基金面上项目: 基于微生物转化和化学修饰探讨续随子烷二萜抑制肿瘤多药耐药性的构效关系(19ZR1406100, 2019.7-2022.07;

3. 国家自然科学基金面上项目: 维药天山堇菜和一枝蒿治疗重症流感的物质基础研究(81473421, 2015.1-2018.12);

4. 国家自然科学基金面上项目: 基于补体抑制作用探讨紫花地丁和夏枯草的清热药效物质(81073025, 2011.1-2013.12);

5. 上海市科委中药现代化专项基金: 紫花地丁清热药效物质基础及其对急性肺损伤的防治作用(09dZ1970100, 2009.6-2012.6);

6. 教育部博士点基金(新教师类) : 清热药夏枯草的清热药效物质基础研究(20100071120052, 2011.1-2013.12);

7. “国家重大新药创制科技重大专项课题: 中药药效物质基础及物质资源库研究关键技术(2009ZX09502-013, 2009.1-2010.12, 课题副组长);

8. 2010国家药品标准提高研究课题:五加皮药材、五加皮饮片国家标准的制定研究(2010.9-2012.12.


研究方向

1. 中草药的药效物质基础及质量控制研究;

2. 小分子天然产物的微生物转化研究。


代表性论著

1. Fan Xiaofan, Li Yingzhe, Wu Tao, Cheng Zhihong*. Screening and identification of neuraminidase inhibitors from Baphicacanthus cusia by a combination of affinity ultrafiltration, HPLC-MS/MS, molecular docking, and fluorescent techniques. Journal of Chromatography B, 2023, 1231: 123924;

2. Zang Yichao, Miao Yu, Wu Tao*, Cheng Zhihong*. Development of a thin-layer chromatography bioautographic assay for neuraminidase inhibitors hyphenated with electrostatic field induced spray ionisation-mass spectrometry for identification of active Isatis indigotica root compounds. Journal of Chromatography A, 2021, 1638: 461597; 

3. Guo Qihui, Li Zeyun, Shen Lulu, Xiao Ying*, Cheng Zhihong*. Quantitative 1H nuclear magnetic resonance (qHNMR) methods for accurate purity determination of glucosinolates isolated from Isatis indigotica roots. Phytochemical Analysis, 2021, 32: 104-111;

4. Ding Pei-Lan, He Chang-Ming,  Cheng Zhi-Hong*, Chen Dao-Feng*. Flavonoids rather than alkaloids as the diagnostic constituents to distinguish Sophorae Flavescentis Radix from Sophorae Tonkinensis Radix et Rhizoma: an HPLC fingerprint study. Chinese Journal of Natural Medicines, 2018, 16(12): 951-960;

5. Qin Yan, Gao Boyan, Shi Haiming, Cao Jie, Yin Chengle, Lu Weiying, Yu Liangli, Cheng Zhihong*. Characterization of flavonol mono-, di-, tri- and tetra-O-glycosides by ultra-performance liquid chromatography-electrospray ionization-quadrupole time-of-flight mass spectrometry and its application for identification of flavonol glycosides in Viola tianschanicaJournal of Pharmaceutical and Biomedical Analysis, 2017, 142: 113-124;

6. Zhang Lei, Shi Jiyao, Tang Jihe, Cheng Zhihong*, Lu Xiaohui, Kong Yao, Wu Tao*. Direct coupling of thin-layer chromatography-bioautography with electrostatic field induced spray ionization-mass spectrometry for separation and identification of lipase inhibitors in lotus leaves. Analytica Chimica Acta, 2017, 967: 52-58;

7. Wu Yiqing, Yin Chengle, Cao Yue, Liu Xin, Yu Jinxiang, Zhang Jian, Yu Boyang, Cheng Zhihong*. Regioselective hydroxylation of lathyrane diterpenoids biocatalyzed by microorganisms and its application in integrated synthesis. Journal of Molecular Catalysis B: Enzymatic, 2016, 133: S352-S359;

8. Du Dongsheng, Lu Yan,  Cheng Zhihong*, Chen Daofeng*. Structure characterization of two novel polysaccharides isolated from the spikes of Prunella vulgaris and their anticomplement activities. Journal of Ethnopharmacology, 2016, 193: 345-353;

9. Qin Yan, Pang Yingming,  Cheng Zhihong*. Needle trap device as a new sampling and preconcentration approach for volatile organic compounds of herbal medicines and its application to the analysis of volatile components in Viola tianschanicaPhytochemical Analysis, 2016, 27(6): 364-374;

10. Yin Chengle, Zhou Jinge, Wu Yiqing, Cao Yue, Wu Tao, Zhang Shoude, Li Honglin,  Cheng Zhihong*. Pterocarpans and triterpenoids from Gueldenstaedtia vernaFitoterapia, 2015, 106: 46-54;

11. Cao Jie, Yin Chengle, Qin Yan,  Cheng Zhihong*, Chen Daofeng. Approach to the study of flavone di-C-glycosides by high performance liquid chromatography-tandem ion trap mass spectrometry and its application to characterization of flavonoid composition in Viola yedoensisJournal of Mass Spectrometry, 2014, 49: 1010-1024;

12. Xiao Guodong, Li Guowen, Chen Liang, Zhang Zijia, Yin Jun-Jie, Wu Tao*, Cheng Zhihong*, Xiaohui Wei, Zhengtao Wang.Isolation of antioxidants from Psoralea corylifolia fruits using high-speed counter-current chromatography guided by thin layer chromatography-antioxidant autographic assay. Journal of Chromatography A, 2010, 1217: 5470-5476;

13. Cheng Zhihong, Zhou Huiping, Luther Marla, Yin Junjie, Yu Liangli*. Effects of wheat antioxidants on oxygen diffusion-concentration products in liposomes and key genes for cholesterol biosynthesis and metabolism in primary rat hepatocytes. Journal of Agricultural & Food Chemistry, 2008, 56(13): 5033-5042;

14. Cheng Zhihong, Guo Yinlong*, Wang Haoyang, Chen Guoqiang. Qualitative and quantitative analysis of quaternary ammonium alkaloids from Rhizoma Corydalis by MALDI-FTMS coupled with a special precipitation reaction using Reinecke salt. Analytica Chimica Acta, 2006, 555: 269-277;

15. Cheng Zhihong, Yu Boyang*, Geoffrey A. Cordell, Qiu Shengxiang*. Biotransformation of quinovic acid glycosides by microbes: direct conversion of the ursane to the oleanane triterpene skeleton by Nocardia sp. NRRL 5646. Organic Letters, 2004, 6(18): 3163-3165. 


联系我们
地址:上海浦东新区张衡路826号
电话:(021-51980000)
邮编:201203