叶德泳
药物化学, 教授, 博士生导师


姓      名

 叶德泳

性      别

 男

职      称

 教授

学      历

 研究生

电      话

 021-51980117

传      真

 021-51980125

电子邮件

 dyye@shmu.edu.cn

个人主页

 

通讯地址

 上海市张衡路826号化学实验南楼317室

个人简介

     1982年上海医科大学药物化学专业本科毕业,1982年至1984年于上海中医药大学中药学院任助教,1987年上海医科大学药物化学专业硕士研究生毕业,1987年起在上海医科大学药学院任教,历任讲师、副教授、教授。19972008年任药学院副院长,20082010年任药物化学教研室主任。19911992年意大利佩鲁贾大学化学系进修;2006年美国北卡罗莱纳大学药学院访问教授。兼任上海市药学会理事,上海市药学会药物化学专业委员会副主任委员,全国药学类本科专业论证评估专家委员会委员。主要从事有机化学、药物化学和药物设计学等教学工作,科研研究方向为小分子药物的合理设计与合成。主编和参编共10余部教材;主持国家自然科学基金项目多项、国家新药创制重大专项、上海市自然科学基金项目、上海市重点科技攻关项目和教育部博士点基金等项目。在国内外学术刊物发表科研论文和教学论文共90余篇,申请国家发明专利20项,其中已授权11项,并申请和获得美国等国家和地区的专利授权。曾获国家教学成果二等奖1项、上海市教学成果一、二和三等奖共4项、宝钢教育基金全国优秀教师奖,上海市育才奖、复旦大学教学名师、复旦大学我心目中的好老师等奖项和称号。



承担科研项目

1.国家重大新药创制科技重大专项,抗动脉粥样硬化潜在原创新药鞘磷脂合酶抑制剂的研究与开发,2018年1月至2020年12月

2.上海市 “科技创新行动计划”生物医药领域科技支撑项目,抗动脉粥样硬化全新靶点鞘磷脂合酶抑制剂的研究与开发,2017年6月至2020年9月

3.中国科学院上海有机化学研究所生命有机化学国家重点实验室 开放课题, 鞘磷脂合成酶光亲和标记探针的设计、合成及化学生物学研究,2015年1月至2017年12月

4.教育部博士点基金(博导类),“新型NS5B 抑制剂的设计合成及抗HCV活性研究”,2014年1月至2016年12月

5.国家自然基金面上项目:作用于活性位点的新型非核苷类NS5B抑制剂的设计合成及抗丙型肝炎病毒活性研究, 2014年1月至2017年12月 




代表性论著


1. Zhang, Xiaodan; Jiang, Lulu; Huang, Ke; Fang, Chuantao; Li, Jian; Yang, Jintong; Li, Huiti; Ruan, Xiaoxue; Wang, Penghui; Mo, Mingguang; Wu, Ping; Xu, Yanhui; Peng, Chao; Uesugi, Motonari; Ye, Deyong*; Yu, Fa-xing*; Zhou, Lu*. Site-selective phosphoglycerate mutase 1 acetylation by a small molecule. ACS Chem. Biol. 15: 632-639, 2020

2. Yan-Fei Chen#, Jiang Bian#, Peng Zhang, Lu-Lu Bu, Yan Shen, Wen-Bo Yu, Xiu-Hong Lu, Xin Lin, De-Yong Ye*, Jian Wang*, Yong Chu*. Design, synthesis and identification of N, N-dibenzylcinnamamide (DBC) derivatives as novel ligands for α-synuclein fibrils by SPR evaluation system, Bioorg Med Chem. 28: 115358, 2020
3. Ke Huang, Lulu Jiang, Ronghui Liang, Huiti Li, Xiaoxue Ruan, Changliang Shan*, Deyong Ye*, Lu Zhou*,Synthesis and biological evaluation of anthraquinone derivatives as allosteric phosphoglycerate mutase 1 inhibitors for cancer treatment. Eur. J. Med. Chem. 168: 45-57, 2019
4. Ke Huang, Lulu Jiang, Huiti Li, Deyong Ye * and Lu Zhou *,Development of Anthraquinone Analogues as Phosphoglycerate Mutase 1 Inhibitors. Molecules, 24, 845, 2019
5. Yali Li, Taomin Huang, Bin Lou, Deyong Ye, Xiangyu Qi, Xiaoxia Li, Shuang Hu, Tingbo Ding, Yan Chen, Yang Cao, Mingguang Mo, Jibin Dong, Min Wei, Yong Chu, Huiti Li, Xian-Cheng Jiang*, Nengneng Cheng*, Lu Zhou*. Discovery, synthesis and anti-atherosclerotic activities of a novel selective sphingomyelin synthase 2 inhibitor. Eur. J. Med. Chem. 163: 864-882, 2019
6. Penghui Wang, Zhining Li, Lulu Jiang, Lu Zhou*, Deyong Ye*. Design and Synthesis of the Diazirine-based Clickable Photo-affinity Probe Targeting Sphingomyelin Synthase 2. Lett Drug Des Discov. 16(6): 678-684, 2019
7. Mingguang Mo, Jintong Yang, Xian-Cheng Jiang, Yu Cao, Jinyu Fei, Yang Chen, Xiangyu Qi, Yong Chu, Lu Zhou*, Deyong Ye*. Discovery of 4-Benzyloxybenzo[d]isoxazole-3-amine Derivatives as Highly Selective and Orally Efficacious Human Sphingomyelin Synthase 2 Inhibitors that Reduce Chronic Inflammation in db/db Mice. J. Med. Chem.  61(18): 8241-8254, 2018
8. Penghui Wang, Lulu Jiang, Yang Cao, Xiaodan Zhang, Bangjing Chen, Shiyu Zhang, Ke Huang, Deyong Ye*, Lu Zhou*. Xanthone derivatives as phosphoglycerate mutase 1 inhibitors: Design, synthesis, and biological evaluation. Bioorg Med Chem 26, (8), 1961-1970, 2018
9. Bin Lou*, Qi Liu, Jiahui Hou, Inamul Kabir, Peipei Liu, Tingbo Ding, Jibin Dong, Mingguang Mo, Deyong Ye, Yang Chen, Hai H. Bui, Kenneth Roth, Yu Cao, Xian-Cheng Jiang, 2-Hydroxy-oleic acid does not activate sphingomyelin synthase activity, J. Biol. Chem.  293(47) :18328–18336,2018
10. Yang Gao, De-Yong Ye*, Wei-Cheng Zhou*, Yong Chu*.The discovery of novel benzothiazinones as highly selective non-ATP competitive glycogen synthase kinase 3β inhibitors for the treatment of ovarian cancer. Eur. J. Med. Chem., 135, 370-381, 2017
11. Qi, X-Y., Cao, Y., Li, Y-L., Mo, M-G., Zhou, L., Ye, D-Y.*, Discovery of the selective sphingomyelin synthase 2 inhibitors with the novel structure of oxazolopyridine, Bioorg Med. Chem. Lett. 27, 3511–3515, 2017
12. Haojun Gong, Lu Zhou*, Deyong Ye*, Xing Gao, Yali Li, Xiangyu Qi and Yong Chu. Novel Dual Inhibitors of Secretory Phospholipase A2 and Sphingomyelin Synthase: Design, Synthesis and Evaluation. Lett. Drug Des. Discov. 13, 1-8, 2016
13. Ya-li Li, Xiang-yu Qi, Hui Jiang, Xiao-dong Deng, Yan-ping Dong, Ting-bo Ding, Lu Zhou Peng Men, Yong Chu, Ren-xiao Wang*, Xian-cheng Jiang*, De-yong Ye*. Discovery, synthesis and biological evaluation of 2-(4-(Nphenethylsulfamoyl)phenoxy)acetamides (SAPAs) as novelsphingomyelin synthase 1 inhibitors. Bioor.Med. Chem. 23: 6173-6184, 2015
14. Dongwei Zhong, Mingming Liu, Yang Cao, Yelin Zhu, Shihui Bian, Jiayi Zhou, Fengjie Wu, Kum-Chol Ryu, Lu Zhou,* and Deyong Ye*. Discovery of Metal Ions Chelator Quercetin Derivatives with Potent Anti-HCV Activities. Molecules. 20: 6978-6999, 2015
15. Xiaodong Deng, Fu Lin, Ya Zhang, Yan Li, Lu Zhou, Bin Lou, Yue Li, Jibin Dong, Tingbo Ding, Xiancheng Jiang, Renxiao Wang*, Deyong Ye* ,Identification of Small Molecule Sphingomyelin synthase inhibitors, Eur. J. Med. Chem. 73:1-7, 2014
16. Bin Lou*, Jibin Dong, Yali Li, Tingbo Ding, Tingting Bi, Yue Li, Xiaodong Deng, Deyong Ye*, Xian-Cheng Jiang. Pharmacologic Inhibition of Sphingomyelin Synthase (SMS) Activity Reduces Apolipoprotein-B Secretion from Hepatocytes and Attenuates Endotoxin-Mediated Macrophage Inflammation. PLoS ONE 9(7): 1-7, 2014










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