1. 中枢神经系统疾病诊断治疗药物的合理设计、合成与研究开发
2. 恶性肿瘤治疗药物的研究开发
3. 药物发现新方法（合成新方法、成药性、结构生物学）的研究开发
4. 药物研究中转化医学手段的探索研究
1.Li Xiao , Yujun Wang, Mumei Zhang, Weiwei Wu, Linghui Kong, Yan Ma, Xuejun Xu, Xiao Liu, Qian He, Yuanyuan Qian, Huijiao Sun, Haihao Wu, Cheng Lin, Huoming Huang, Rongrong Ye, Shuang Jiang, Rufeng Ye, Congmin Yuan, Shengyang Fang, Dengqi Xue, Xicheng Yang, Hao Chen, Yilin Zheng, Linqian Yu, Qiong Xie, Lan Zheng, Wei Fu, Wei Li*, Zhuibai Qiu, Jinggen Liu*, Liming Shao*. Discovery of a highly selective and potent kappa opioid receptor agonist from N-cyclopropylmethyl-7α-phenyl- 6,14-endoethano-tetrahydro- northebaines with reduced central nervous system (CNS) side effects navigated by the message-address concept. J. Med. Chem., 2019, 62(24): 11054-70.
2.Shengyang Fang, Haihua Yu, Xicheng Yang, Jianqi Li*, Liming Shao*. Nickel-Catalyzed Construction of 2,4-Disubstituted Imidazoles via C-C Coupling and C-N Condensation Cascade Reactions. Adv. Synth. Catal., 2019, 361, 3312-3317.
3.Yilin Zheng, Li Xiao, Qiong Xie, Liming Shao*. Palladium-Catalyzed Synthesis of beta,beta-Diaryl alpha,beta-Unsaturated Ketones. Synthesis-Stuttgart., 2019, 51, 1455-1465.
4.Dengqi Xue, Yulong Xu, Haihua Yu, Liming Shao*. Metal-Free Radical Cyclization of Vinyl Isocyanides with Alkanes: Synthesis of 1-Alkylisoquinolines. Synthesis-Stuttgart., 2019, 51, 874-884.
5.Li-li Xu, Huijun Gao, Kenneth I. Kaitin, Liming Shao*. Reforming China's drug regulatory system. Nat. Rev. Drug. Discov., 2018, 17, 858.
6.Xicheng Yang, Jian Shen, Lulu Jiang, Wei Li, Mingcheng Yu, Guanxing Pan, Yu-rong Yan, Chenghan Zhang, Wanwan Jia, Li Xiao, Haihua Yu, Hao Chen, Yilin Zheng, Linqian Yu, Qiong Xie*, Lu Zhou*, Liming Shao*. Discovery, cocrystallization and biological evaluation of novel piperidine derivatives as high affinity Ls-AChBP ligands possessing alpha-7 nAChR activities. Eur. J. Med. Chem., 2018, 160, 37-48.
7.Xicheng Yang, Haihua Yu, Yulong Xu, Liming Shao*. Regioselective Access to 3-Aryl-1-aminoisoquinolines via Nickel(I)-Catalyzed C-C and C-N Cascade Coupling Reactions from the Substituted 2-(Cyanomethyl)benzonitriles. J. Org. Chem., 2018, 83, 9682-9695.
8.HuiJiao Sun, Yuhua Wang, Congmin Yuan, Linghui Kong, Xuejun Xu, Yujun Wang, Haihao Wu, Cheng Lin, Yuanyuan Qian, Huoming Huang, Li Xiao, Xiao Liu, Qian He, Shengyang Fang, Dengqi Xue, Xicheng Yanga, Hao Chen, Yilin Zheng, Lan Zheng, Linqian Yu, Qiong Xie, Wei Fu, Wei Li*, Jinggen Liu*, Zhuibai Qiu, Liming Shao*. 7β-methyl substituent is a structural locus associated with activity cliff for nepenthone analogues. Bioorg. Med. Chem., 2018, 26 (14), 4254-4263.
9.Yulong Xu, Hao Chen, Wei Li, Qiong Xie, Linqian Yu, Liming Shao*. Synthetic access to isoxazoline-functionalized isoquinolines via microwave-assisted iminoxyl radical-participated cascade cyclization of vinyl isocyanides. Org. Biomol. Chem., 2018, 16 (27): 4996-5005.
10.Yulong Xu, Xicheng Yang, Yiyi Chen, Hao Chen, Huijiao Sun, Wei Li, Qiong Xie, Linqian Yu, Liming Shao*. Discovery of novel 20S proteasome inhibitors by rational topology-based scaffold hopping of bortezomib. Bioorg. Med. Chem. Lett., 2018, 28 (12), 2148-2152.
11.Dengqi Xue, Hao Chen, Yulong Xu, Haihua Yu, Linqian Yu, Wei Li, Qiong Xie*, Liming Shao*. Microwave-assisted synthesis of hydroxyl-containing isoquinolines by metal-free radical cyclization of vinyl isocyanides with alcohols. Org. Biomol. Chem., 2017, 15(47), 10044-10052.
12.Li Xiao, Yilin Zheng, Qiong Xie*, Liming Shao*. Palladium-Catalyzed Cascade Saegusa-Heck Reaction: Synthesis of beta,beta-Diarylacroleins from Arylpropanals and Aryl Iodides. Eur. J. Org. Chem., 2017, 5880-5883.
13.Hongpeng Sun, Li Xiao, Wei Li, Qiong Xie*, Liming Shao*. On-Water Silver(I)-Catalyzed Cycloisomerization of Acetylenic Free Amines/Amides towards 7-Azaindole/Indole/Isoquinolone Derivatives. Synthesis-Stuttgart, 2017, 49, 4845-4852.
14.Qing Liu, Xiaoqing Cai, Dehua Yang, Yi Chen, Yafang Wang, Li-ming Shao*, Ming-wei Wang*. Cycloalkane analogues of sinefungin as EHMT1/2 inhibitors. Bioorg. Med. Chem., 2017, 25, 4579-4594.
15.Yulong Xu, Hao Chen, Wei Li, Qiong Xie, Linqian Yu, Liming Shao*. Microwave-Assisted Radical Insertion/Cyclization of Vinyl Isocyanides for the Synthesis of Multi-Substituted Isoquinolines. Chemistryselect, 2017, 2, 8033-8038.
16.Haihua Yu, Li Xiao, Xicheng Yang, Liming Shao*. Controllable access to multi-substituted imidazoles via palladium(II)-catalyzed C-C coupling and C-N condensation cascade reactions. Chem. Commun., 2017, 53, 9745-9748.
17.Jian Shen#, Xicheng Yang#, Mingcheng Yu, Li Xiao, Xunjie Zhang, Huijiao Sun, Hao Chen, Guanxin Pan, Yurong Yan, Sichen Wang, Wei Li*, Lu Zhou*, Qiong Xie, Linqian Yu, Yonghui Wang, Liming Shao*. Discovery, synthesis, biological evaluation and structure-based optimization of novel piperidine derivatives as acetylcholine-binding protein ligands. Acta. Pharmacol. Sin., 2017, 38(1): 146-155.
18.Yulong Xu, Yiyi Chen, Wei Li, Qiong Xie, Liming Shao*. Microwave-Assisted Synthesis of Phenanthridines by Radical Insertion/Cyclization of Biphenyl Isocyanides. J. Org. Chem., 2016; 81: 8426-35.
19. Liming Shao*, Lili Xu. Qiu Li, R. Chakravarth, Ziling Yang & Kenneth I Kaitin, REGULATORY WATCH Innovative drug availability in China. Nat. Rev. Drug. Discov., 2016, 15, 739-740.
20. Liming Shao, Una C. Campbell, Q. Kevin Fang, Noel A. Powell, John E. Campbell, Philip G. Jones, Taleen Hanania, Vadim Alexandrov, Irene Morganstern, Emily Sabath, Hua M. Zhong, Thomas H. LargeKerry L. Spear*. In vivo phenotypic drug discovery: applying a behavioral assay to the discovery and optimization of novel antipsychotic agents. Med. Chem. Commun., 2016, 7, 1093-1101.
21.Yulong Xu, Qiong Xie, Wei Li, Hongpeng Sun, Yonghui Wang, Liming Shao*, A convenient aqueous copper-catalyzed synthesis of quinazolinones. Tetrahedron, 2015, 72(29):4853-4958.
