邵黎明
药物化学, 教授, 博士生导师

姓      名

 邵黎明

性      别

 男

职      称

 教授

学      历

 博士

电      话

 021-51980201 

传      真

 021-51980017

电子邮件

 limingshao@fudan.edu.cn

个人主页

 

通讯地址

 上海市浦东新区张衡路826号科研楼裙西108室

教育经历 1978.09 – 1982.07 复旦大学化学系, 有机化学专业,理学学士
1987.09 – 1990.03 日本东京大学工学部, 工业化学专业,工学硕士
1990.03 – 1993.03 日本东京大学工学部, 工业化学专业,工学博士
1993.04 – 1996.08 哈佛大学, 化学和化学生物系, 博士后研究员
 
工作经历 1982.08 – 1987.05 世界卫生组织人类生殖研究中心/上海计划生育研究所, 药物研究室,助理研究员

1998.09 – 2010.10  Sepracor公司, 药物研发及临床前研究部 (美国, 马萨诸塞州)
2008-2010  资深总监
2005-2008  总监
2001-2005  副总监
2000-2001  资深科学家
1998-2000  科学家
2010.10 – 2012.05 Sunovion公司, 临床前研究及转化医学部 (美国, 马萨诸塞州)资深总监
2012.06 –至今复旦大学药学院,国家千人计划特聘教授

 

专家类别 教授、国家千人计划

 

职       务 博士生导师、上海药物创制产业化开发中心主任、复旦大学医药健康产业发展战略研究中心主任

 

主要科研贡献
     参与和主持了各类药物的研究与开发工作,其中4个化合物获美国FDA认准进入临床试验,曾参与避孕药的研发,其中一个药物获得中国FDA 批准上市

 

研究方向

1. 中枢神经系统疾病诊断治疗药物的合理设计、合成与研究开发
2. 恶性肿瘤治疗药物的研究开发
3. 药物发现新方法(合成新方法、成药性、结构生物学)的研究开发
4. 药物研究中转化医学手段的探索研究

 
 
代表性论著
1. Yulong Xu*, Qiong Xie, Wei Li, Hongpeng Sun, Yonghui Wang, Liming Shao*A convenient aqueous copper-catalyzed synthesis of quinazolinones. Tetrahedron 71(29): 4853-4858, 2015
2. Liming Shao*, Wei Li, Qiong Xie, Hong Yin. Triple reuptake inhibitors: a patent review (2006 - 2012). Expert Opin. Ther. Pat., 24(2): 131-154, 2014.
3. Liming Shao*, Scott C. Malcolm, Michael C. Hewitt, Fengjiang Wang, Jianguo Ma, Una Campbell, Nancy Spicer, Sharon Engel, Larry Hardy, Zhi-Dong Jiang, Rudy Schreiber, Kerry Spear, Mark A. Varney; Synthesis and pharmacologic characterization of 3-(3,4dichlorophenyl)octahydrocyclopenta[c]pyrroles, a novel bicyclic triple reuptake inhibitor; J. Med. Chem., 54, 5283–5295, 2011
4. Liming Shao*, Michael C. Hewitt b, Fengjiang Wang, Scott C. Malcolm, Jianguo Ma, John E. Campbell, Una C. Campbell, Sharon R. Engel, Nancy A. Spicer, Larry W. Hardy, Rudy Schreiber, Kerry L. Spear, Mark A. Varney; Discovery of N-methyl-1-(1-phenylcyclohexyl) methanamine, a novel triple serotonin, norepinephrine, and dopamine reuptake inhibitor; Bioorg. Med. Chem. Lett., 21, 1438–1441,2011
5. Liming Shao*, Michael C. Hewitt, Fengjiang Wang, Scott C. Malcolm, Jianguo Ma, John E. Campbell, Una C. Campbell, Sharon R. Engel, Nancy A. Spicer, Larry W. Hardy, Rudy Schreiber, Kerry L. Spear, Mark A. Varney; Discovery of N-methyl-1-(1-phenylcyclo- hexyl) ethanamine, a novel triple serotonin, norepinephrine and dopamine reuptake inhibitor; Bioorg. Med. Chem. Lett., 21, 1434–1437, 2011
6. Liming Shao*, Jianguo Ma, Fengjiang Wang, Scott C. Malcolm, Michael C. Hewitt, Una C. Campbell, Nancy A. Spicer, Larry W. Hardy, Rudy Schreiber, Kerry L. Spear, Mark A. Varney; Discovery of 1-(3,4-dichlorophenyl)-N,N- dimethyl-1,2,3,4- tetrahydroquinolin-4-amine, a dual serotonin and dopamine reuptake inhibitor; Bioorg. Med. Chem. Lett., 21, 520–523, 2011
7. Liming Shao*, Fengjiang Wang, Scott C. Malcolm, Jianguo Ma, Michael C. Hewitt, Una C. Campbell, Larry R. Bush, Nancy A. Spicer, Sharon R. Engel, Lakshmi D. Saraswat, Larry W. Hardy, Patrick Koch,Rudy Schreiber, Kerry L. Spear, Mark A. Varney; Synthesis and pharmacological evaluation of 4-(3,4-dichlorophenyl) -N-methyl-1,2,3,4-tetrahydronaphthalenyl amines as triple reuptake inhibitors; Bioorg. Med. Chem., 19, 663–676, 2011
8. Shao, Liming; Wang, Fengjiang; Malcolm, Scott C; Hewitt, Michael C; Bush, Larry R; Ma, Jianguo; Varney, Mark A; Campbell, Una; Engel, Sharon R; Hardy, Larry W; Koch, Patrick; Campbell, John E; Cycloalkylamine as monoamine reuptake inhibitors, 2007-08-30, US2007/0203111A1
9. Shao, Liming; Wang, Fengjiang; Malcolm, Scott C; Hewitt, Michael C; Bush, Larry R; Varney, Mark A; Campbell, Una; Engel, Sharon R; Hardy, Larry W; Koch, Patrick; Ma, Jianguo; Tetralone-based monoamine reuptake inhibitors, 2007-08-27, US2007/0197588A2
10. Shao, Liming; Wang, Fengjiang; Malcolm, Scott C; Hewitt, Michael C; Bush, Larry R; Varney, Mark A; Campbell, Una; Engel, Sharon R; Hardy, Larry W; Koch, Patrick; Ma, Jianguo. Tetralone-based monoamine reuptake inhibitors, 2007-07-19, WO2007/081542A2
11. Shao, Liming; Wang, Fengjiang; Malcolm, Scott C; Hewitt, Michael C; Bush, Larry R; Ma, Jianguo; Varney, Mark A; Campbell, Una; Engel, Sharon R; Hardy, Larry W; Koch, Patrick; Campbell. John E; Cycloalkylamine as monoamine reuptake inhibitors, 2007-07-19,WO2007/081857A2
12. Aquila, Brian M; Bannister Thomas D; Cuny, Gregory D; Hauske, James R; Holland, Joanne M; Persons, Paul E; Radeke, Heike; Wang, Fengjiang; Shao, Liming; Ligands for monoamine receptors and transporters, and methods of use thereof, 2006-11-07, US7132551B2
13. Aquila, Brian, M.; Bannister, Thomas, D.; Cuny, Gregory, D.; Hauske, James, R.; Holland, Joanne, M.; Persons, Paul, E.; Radeke, Heike, S.; Wang, Fengjiang; Shao, Liming;Ligand for a monoamine receptor or transporter for treating addiction or dependence, 2005-08-25, WO05077463A3
14. Aquila, Brian, M.; Bannister, Thomas, D.; Cuny, Gregory, D.; Hauske, James, R.; Holland, Joanne, M.; Persons, Paul, E.; Radeke, Heike, S.; Wang, Fengjiang; Shao, Liming; Method of treating addiction or dependence using a ligand for a monoamine receptor or transporter, 2005-08-25, WO05077463A2
15. Aquila, Brian M.; Bannister, Thomas D.; Cuny, Gregory D.; Hauske, James R.; Holland, Joanne M.; Persons, Paul E.; Radeke, Heike S.; Wang, Fengjiang; Shao, Liming;Method of treating addiction or dependence using a ligand for a monoamine receptor or transporter, 2005-04-14, US20050080078A1 
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