孙域
药物化学, 青年研究员

姓      名

 孙域

性      别

  男

职      称

 青年研究员

学      历

 博士

电      话

 

传      真

 

电子邮件

  ysunpharm@fudan.edu.cn

个人主页

 https://www.x-mol.com/groups/sunyu

通讯地址

 上海浦东新区张衡路826号化学实验楼(南)305室 邮编201203

 

教育经历
2011-2016 中国科学院上海有机化学研究所 博士(导师:李昂 研究员)

2007-2011 复旦大学药学院 学士

工作经历
2020-至今 复旦大学药学院 青年研究员

2017-2020 波士顿学院 博士后(导师:Prof. Amir H. Hoveyda)

2016-2017 中国科学院上海有机化学研究所 助理研究员

获奖及荣誉
2016 Reaxys PhD Prize(入围奖)

2014 中国科学院院长优秀奖

2013 Special Symposium Award, Roche and Royal Society of Chemistry Symposium

研究方向
1. 具有生物活性的复杂天然产物的全合成

2. 过渡金属催化的高立体专一性反应的开发及其在天然产物、药物合成中的应用

3. 基于天然产物的先导化合物发现及构效关系研究

代表性论著
1. Y. Sun, Y. Zhou, Y. Shi, J. del Pozo, S. Torker, and A. H. Hoveyda* Copper?Hydride-Catalyzed Enantioselective Processes with Allenyl Boronates. Mechanistic Nuances, Scope, and Utility in Target-Oriented Synthesis, J. Am. Chem. Soc. 2019, 141, 12087.

2. Y. Sun, P. Chen, D. Zhang, M. Baunach, C. Hertweck, and A. Li,* Bioinspired Total Synthesis of Sespenine, Angew. Chem. Int. Ed. 2014, 53, 9012.

3. Y. Sun, R. Li, W. Zhang, and A. Li,* Total Synthesis of Indotertine A and Drimentines A, F, and G, Angew. Chem. Int. Ed. 2013, 52, 9201.

4. Y. Sun, Z. Meng, P. Chen, D. Zhang, M. Baunach, C. Hertweck, and A. Li,* A concise total synthesis of sespenine, a structurally unusual indole terpenoid from Streptomyces, Org. Chem Front. 2016, 3, 368.

5. H. Li, Y. Sun, Q. Zhang, Y. Zhu, S. Li, A. Li, and C. Zhang,* Elucidating the Cyclization Cascades in Xiamycin Biosynthesis by Substrate Synthesis and Enzyme Characterizations, Org. Lett. 2015, 17, 306.

6. Q. Zhang, H. Li, Y. Sun, L. Yu, Y. Zhu, H. Zhu, L. Zhang, S. Li, Y. Shen, C. Tian, A. Li, H. Liu * and C. Zhang,* Characterization of the flavoenzyme Xia K as an N-hydroxylase and implications in indolosesquiterpene diversification, Chem. Sci. 2017, 8, 5067.

7. J. Pei, S. Zhou, F. Yang, Y. Sun, A. Li,* W. Zhang,* and W. He,* Identification and mechanistic studies of a cell cycle regulator JP18 from a library of synthetic indole terpenoid mimics, Chem. Asian J. 2016, 11, 2715.

8. X. Xiong, D. Zhang, J. Li, Y. Sun, S. Zhou, M. Yang, H. Shao,* and A. Li,* Synthesis of Indole Terpenoid Mimics via a Functionality-Tolerated Eu(fod)3-Catalyzed Conjugate Addition, Chem. Asian J. 2015, 10, 869.

9. S. Zhou, D. Zhang, Y. Sun, R. Li, W. Zhang, and A. Li,* Intermolecular Conjugate Addition of Pyrroloindoline and Furoindoline Radicals to α,β-Unsaturated Enones via Photoredox Catalysis, Adv. Synth. Catal. 2014, 2867.

10. M. Bian, Z. Wang, X. C. Xiong, Y. Sun, C. Matera, K. C. Nicolaou,* and A. Li,* Total Syntheses of Anominine and Tubingensin A, J. Am. Chem. Soc. 2012, 134, 8078.


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