司长梅
天然药物学, 副研究员

姓      名

 司长梅

性      别

 

职      称

 青年副研究员

学      历

 博士

电      话

15921901271

传      真

 

电子邮件

 sicm@fudan.edu.cn

个人主页

 

通讯地址

 上海市浦东新区张衡路826号化学南楼205  

 

教育经历

2007.09 – 2011.06 西北农林科技大学理学院(学士,应用化学专业)

2011.09 – 2016.06 西北农林科技大学理学院(博士,化学生物学专业)

工作经历

2016.07 – 2018.12  复旦大学药学院,博士后

2019.01 – 至今       复旦大学药学院,青年副研究员

承担科研项目情况


1. 国家自然基金青年科学基金项目,基于串联环合反应高效合成苯并杂环类生物碱及其活性评价研究(No. 217020322018/01-2020/12,26万元,主持)

2. 复旦大学引进人才科研基金(2019/01-2021/12,50万元)

3. 北京工商大学植物资源研究开发北京市重点实验室开放基金,具有抗氧化作用核苷类衍生物的研究No. PRRD-2019-YB22019/07-2020/065万,主持)
4. 中国博士后科学基金第60批1级资助,基于ADC”弹头的两种抗癌手性肽的多样性研究(No. 2016M6002872016/09-2018/088万元,结题)



研究方向

以活性为导向,开展中药活性组分的不对称合成、结构修饰与改造、活性评价等。

代表性论著

      1. Xue-Mei Wang, Yi-Wen Liu, Rui-Jun Ma, Chang-Mei Si* and Bang-Guo Wei* Synthesis of 1,4- and 1,5-Amino Alcohols via Nucleophilic Addition of Semicyclic N,O-Acetal with Organozinc Reagents. J. Org. Chem. 2019, 84, 11261-11267;

2. Xue-Mei Wang, Yi-Wen Liu, Qiao-E Wang, Zhu Zhou, Chang-Mei Si* and Bang-Guo Wei* A divergent method to key unit of tubulysin V through one-pot diastereoselective Mannich process of N,O-acetal with ketone. Tetrahedron 2019, 75, 260-268;

3. Wen Zhou, Yan-Xue Zhang, Xiao-Di Nie, Chang-Mei Si,* Xun Sun and Bang-Guo Wei* Approach to Chiral 1?Substituted Isoquinolone and 3?Substituted Isoindolin-1-one by Addition?Cyclization Process J. Org. Chem. 2018, 83, 9879?9889;

4. Zhuo-Ya Mao, Yi-Wen Liu, Pan Han, Han-Qing Dong, Chang-Mei Si,* Bang-Guo Wei,* and Guo-Qiang Lin Regio- and Stereoselective Cascades via Aldol Condensation and 1,3-Dipolar Cycloaddition for Construction of Functional Pyrrolizidine Derivatives Org. Lett. 2018, 20, 1090?1093;

5. Pan Han, Zhu Zhou, Chang-Mei Si,* Xian-Yi Sha, Zheng-Yi Gu,* Bang-Guo Wei,* and Guo-Qiang Lin Asymmetric Synthesis of Rupestonic Acid and Pechueloic Acid Org. Lett. 2017, 196732?6735;

6. Wen Zhou, Xiao-Di Nie, Yu Zhang, Chang-Mei Si*, Zhu Zhou, Xun Sun, Bang-Guo Wei* A practical approach to asymmetric synthesis of dolastatin 10. Org. Biomol. Chem., 2017, 15, 6119-6131.

7. Yi-Wen Liu, Pan Han, Wen Zhou, Zhuo-Ya Mao, Chang-Mei Si*, Bang-Guo Wei* Asymmetric syntheses of epohelmins A and B by In-mediated allylation. Org. Biomol. Chem., 2016, 14, 10714-10722.

8. Chang-Mei Si, Wei Huang, Zhen-Ting Du, Bang-Guo Wei* and Guo-Qiang Lin Diastereoconvergent Synthesis of trans-5-Hydroxy-6-Substituted-2-Piperidinones by Addition?Cyclization?Deprotection Process. Org. Lett., 2014, 16, 4328?4331.

9. Chang-Mei Si, Zhuo-Ya Mao, Han-Qing Dong, Zhen-Ting Du, Bang-Guo Wei* and Guo-Qiang Lin Divergent Method to trans-5-Hydroxy-6-alkynyl/alkenyl-2-piperidinones: Syntheses of (-)-Epiquinamide and (+)-Swainsonine. J. Org. Chem., 2015, 80, 5824-5833.

10. Chang-Mei Si, Zhuo-Ya Mao, Yi-Wen Liu, Zhen-Ting Du, Bang-Guo Wei* and Guo-Qiang Lin Stereoselective Formation of Chiral trans-4-Hydroxy-5-Substituted 2-Pyrrolidinones: Syntheses of Streptopyrrolidine and 3-epi-Epohelmin A. Org. Chem. Front., 2015, 2, 1485-1499.

11. Chang-Mei Si, Lu-Ping Shao, Zhuo-Ya Mao, Wen Zhou, Bang-Guo Wei* An efficient approach to trans-4-hydroxy-5-substituted 2-pyrrolidinones through a stereoselective tandem Barbier process: divergent syntheses of (3R,4S)-statines, (+)-preussin and (-)-hapalosin. Org. Biomol. Chem., 2017, 15, 649-661.

12. Lu-Ping Shao#, Chang-Mei Si#, Zhuo-Ya Mao, Wen Zhou, Tadeusz F. Molinski,* Bang-Guo Wei* and Guo-Qiang Lin Synthesis and structure revision of symplocin A Org. Chem. Front., 2017, 4, 995–1004.  (# co-first author) 



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