潘礼龙
药理学与生物化学, 讲师

姓      名

 潘礼龙

性      别

 男

职      称

 讲师

学      历

 博士

电      话

 021-51980159

传      真

 

电子邮件

 panlilong@fudan.edu.cn

个人主页

 

通讯地址

 上海市浦东新区张衡路826号科研楼417室

教育经历

2008/09-2011/07,复旦大学,药学院,博士 (导师:朱依谆 教授)
2004/09-2007/07,安徽中医学院,药学院,硕士 (导师: 戴敏 教授)
2002/09-2004/07,安徽中医学院,药学院,本科

 

工作经历

2013/9-至今,复旦大学药学院药理教研室,讲师

2011/09-2013/09,复旦大学,上海医学院,博士后 

研究方向

心血管分子药理学,主要从事动脉粥样硬化、缺血性心脏病、心脏重构等疾病的发病机制及新药发现研究

 

主持科研项目情况

1. NSFC面上项目,JMJD3在动脉粥样硬化过程中作用及硫化氢调控研究(№: 81573420 );

2. NSFC青年基金项目,Nox4/ROS在H2S抗心肌纤维化中的作用研究(№: 81202528);

3. 复旦大学“卓学计划”项目,2015.04;

4. 中央高校青年教师科研能力提升项目,CSE/H2S调控血管炎症反应的新机制探索(№: 20520133219) ;

5. 中国博士后基金特别资助,硫化氢在急性心肌损伤中免疫炎症调节作用(№: 2013T60417);

6. 中国博士后基金,Nox4/ROS在H2S抗AngII诱导的心肌纤维化反应中作用研究(№: 2012M511041 );

7. 上海博士后基金,Nox4/ROS在H2S抗内皮细胞炎症反应中作用研究(№: 12R21411900);

8. 复旦大学新教师基金,Nox4在调控VSMC衰老过程中作用及机制研究

 

获奖

1. 潘礼龙,中国药理学会,施维雅奖,2014.09;

2. 朱依谆,刘新华,潘礼龙,等,科学中药理念的开发新药的研究,上海市药学会科技奖二等奖,2013.12;

3. 朱依谆,刘新华,潘礼龙,等,1类新药SCM-198(益母草碱)药效学研究和临床前开发,中国药学会科技奖三等奖,2011.07;

 

代表性论文

目前在Antioxid Redox Signal、Free Radic Biol Med、Int J Cardiol、BBA、Athersclerosis等国际学术知名期刊上以第一作者/通讯作者发表了10余篇SCI论文

[1] Pan LL, Liu XH, Gong QH, Yang HB, Zhu YZ. Role of cystathionine gamma-lyase/hydrogen sulfide pathway in cardiovascular disease: a novel therapeutic strategy? Antioxid Redox Signal 2012; 17(1):106-18.

[2] Pan LL, Liu XH, Gong QH, Wu D, Zhu YZ. Hydrogen sulfide attenuated tumor necrosis factor-alpha-induced inflammatory signaling and dysfunction in vascular endothelial cells. PLoS One 2011; 6(5):e19766.

[3] Pan LL, Liu XH, Shen YQ, Wang NZ, Xu J, Wu D, et al. Inhibition of NADPH oxidase 4-related signaling by sodium hydrosulfide attenuates myocardial fibrotic response. Int J Cardiol 2013; 168(4):3770-8.

[4] Pan LL, Liu XH, Gong QH, Zhu YZ. S-Propargyl-cysteine (SPRC) attenuated lipopolysaccharide-induced inflammatory response in H9c2 cells involved in a hydrogen sulfide-dependent mechanism. Amino Acids 2011; 41(1):205-15.

[5] Pan LL, Liu XH, Jia YL, Wu D, Xiong QH, Gong QH, et al. A novel compound derived from danshensu inhibits apoptosis via upregulation of heme oxygenase-1 expression in SH-SY5Y cells. Biochim Biophys Acta 2013; 1830(4):2861-71.

[6] Pan LL, Liu XH, Zheng HM, Yang HB, Gong QH, Zhu YZ. S-propargyl-cysteine, a novel hydrogen sulfide-modulated agent, attenuated tumor necrosis factor-alpha-induced inflammatory signaling and dysfunction in endothelial cells. Int J Cardiol 2012; 155(2):327-32.

[7] Pan LL, Wang XL, Wang XL, Zhu YZ. Sodium Hydrosulfide Prevents Myocardial Dysfunction through Modulation of Extracellular Matrix Accumulation and Vascular Density. Int J Mol Sci 2014; 15(12):23212-26.

[8] Pan LL, Wang J, Jia YL, Zheng HM, Wang Y, Zhu YZ. Asymmetric synthesis and evaluation of danshensu-cysteine conjugates as novel potential anti-apoptotic drug candidates. Int J Mol Sci 2014; 16(1):628-44.

[9] Pan LL, Dai M. Paeonol from Paeonia suffruticosa prevents TNF-alpha-induced monocytic cell adhesion to rat aortic endothelial cells by suppression of VCAM-1 expression. Phytomedicine 2009; 16(11):1027-32.

[10] Liu X*, Pan L*, Wang X, Gong Q, Zhu YZ. Leonurine protects against tumor necrosis factor-alpha-mediated inflammation in human umbilical vein endothelial cells. Atherosclerosis 2012; 222(1):34-42. (co-first author)

[11] Liu XH*, Pan LL*, Deng HY, Xiong QH, Wu D, Huang GY, et al. Leonurine (SCM-198) attenuates myocardial fibrotic response via inhibition of NADPH oxidase 4. Free Radic Biol Med 2013; 54:93-104. (co-first author)

[12] Liu XH*, Pan LL*, Gong QH, Zhu YZ. Antiapoptotic effect of novel compound from Herba leonuri - leonurine (SCM-198): a mechanism through inhibition of mitochondria dysfunction in H9c2 cells. Curr Pharm Biotechnol 2010; 11(8):895-905. (co-first author)

[13] Liu XH*, Pan LL*, Jia YL, Wu D, Xiong QH, Wang Y, et al. A novel compound DSC suppresses lipopolysaccharide-induced inflammatory responses by inhibition of Akt/NF-kappaB signalling in macrophages. Eur J Pharmacol 2013; 708(1-3):8-13. (co-first author)

[14] Wang LJ, Xiong J#, Liu ST, Pan LL#, Yang GX, Hu JF#. ent-Abietane-Type and Related Seco-/Nor-diterpenoids from the Rare Chloranthaceae Plant Chloranthus sessilifolius and Their Antineuroinflammatory Activities. J Nat Prod 2015; 78(7):1635-46. (co-corresponding Author)




 

 

 

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