郭薇
药理学与生物化学, 讲师

姓      名

 郭薇

性      别

 女

职      称

 讲师

学      历

 博士

电      话

 51980043

传      真

 

电子邮件

 guowei@fudan.edu.cn

个人主页

 

通讯地址

上海市张衡路826号

教育经历
1991.09 – 1996.06 哈尔滨医科大学临床医学专业,学士
1999.09– 2002.07   哈尔滨医科大学普通外科,硕士
2002.09 – 2007.06 哈尔滨医科大学药理学专业,博士
 
工作经历
1996.09 – 2002.08   哈尔滨市第一医院普外科,主治医师
2007.07 – 2009.11 复旦大学药学院,博士后
2009.12 –  复旦大学药学院,讲师
2013.12 – 2014.12   加拿大湖首大学王睿教授课题组,访问学者

 

承担科研项目情况

1. 2007年重大国家重点基础研究发展计划973项目2007CB512006子课题“缺血性心衰的早期干预新途径及其细胞分子机制”,参加人。
2. 2008年“重大新药创制”科技重大专项 “创新药物研究开发技术平台建设”中“药物筛选新靶标的发现和研究”,参加人。
3. 硫化氢对急性心梗心肌细胞信号转导机制的影响,2008年上海市博士后科研基金获资助4.0万元。


 
研究方向
1. 心血管药理
2. 离子通道药理学
代表性论著

1. The Cardioprotective Effects of Hydrogen Sulfide in Heart Diseases: From Molecular Mechanisms to Therapeutic Potential.Shen Y, Shen Z, Luo S, Guo W*, Zhu YZ*. Oxid Med Cell Longev. 2015;2015:925167. doi: 10.1155/2015/925167. Epub 2015 May 11(*Corresponding author).
2. miRNA-30 family inhibition protects against cardiac ischemic injury by regulating cystathionine-γ-lyase expression.Shen Y, Shen Z, Miao L, Xin X, Lin S, Zhu Y, Guo W*, Zhu YZ*.Antioxid Redox Signal. 2015 Jan 20;22(3):224-40. doi: 10.1089/ars.2014.5909. Epub 2014 Oct 27(*Corresponding author).
3. SPRC protects hypoxia and re-oxygenation injury by improving rat cardiac contractile function and intracellular calcium handling.Liang YH, Shen YQ, Guo W*, Zhu YZ*.Nitric Oxide. 2014 Sep 15;41:113-9. doi: 10.1016/j.niox.2014.05.010. Epub 2014 Jun 2(*Corresponding author).
4. S-propargyl-cysteine, a novel water-soluble modulator of endogenous hydrogen sulfide, promotes angiogenesis through activation of signal transducer and activator of transcription 3.Kan J$, Guo W$, Huang C, Bao G, Zhu Y, Zhu YZ.Antioxid Redox Signal. 2014 May 20;20(15):2303-16. doi: 10.1089/ars.2013.5449. Epub 2014 Jan 30($co-first author).
5. Hydrogen sulfide and translational medicine.Guo W, Cheng ZY, Zhu YZ.
ActaPharmacol Sin. 2013 Oct;34(10):1284-91. doi: 10.1038/aps.2013.127. Review.
6. Daphnoretin-induced apoptosis in HeLa cells: a possible mitochondria-dependent pathway.Yang ZY, Kan JT, Cheng ZY, Wang XL, Zhu YZ, Guo W*.Cytotechnology. 2014 Jan;66(1):51-61. doi: 10.1007/s10616-013-9536-8. Epub 2013 Oct 4.
7. Hydrogen sulfide as an endogenous modulator in mitochondria and mitochondria dysfunction.Guo W, Kan JT, Cheng ZY, Chen JF, Shen YQ, Xu J, Wu D, Zhu YZ.Oxid Med Cell Longev. 2012;2012:878052. doi: 10.1155/2012/878052. Epub 2012 Dec 5. Review.
8. Yanfei Zhang$, Wei Guo$, Yadan Wen, QinghuiXiong, Hongrui Liu, Jian Wu, YunzengZou, Yizhun Zhu. SCM-198 attenuates early atherosclerotic lesion in hypercholesterolemic rabbits via modulation of inflammation and oxidative stress pathways. Atherosclerosis.Volume 224, Issue 1, 2012: 43–50 ($co-first author).
9. Liu C, Guo W, Shi X, Kaium MA, Gu X, Zhu YZ. Leonurine-cysteine analog conjugates as a new class of multifunctional anti-myocardial ischemia agent. Eur J Med Chem. 2011 Sep;46(9):3996-4009.
10. MAERZ Stefanie, LIU Chun-Hua, GUO Wei, ZHU Yi-Zhun. Anti-ischemic effects of bilobalide on neonatal rat cardiomyocytes and the involvement of the platelet-activating factor receptor. Bioscience Reports. 2011, vol. 31, no. 5: 439–447.
11. Xianli Wang, Qian Wang, Wei Guo, Yi-Zhun Zhu. Hydrogen sulfide attenuates cardiac dysfunction in a rat model of heart failure: a mechanism through cardiac mitochondrial protection. Bioscience Reports. 2010,31(2): 87-98.
12. YANG Zhenyu,GUO Wei*. Effects of astragalusmembranaceus injection on smooth muscle cells of small coronary arteries in experimental hyperlipidemic rats. Chinese Journal of Clinical Pharmacy. 2009, 18(2): 69-74(*Corresponding author).
13. Wei Guo, Yizhun Zhu. Voltage-gated calcium channels play an essential role in H2S preconditioning-induced cardioprotection in rats. ActaPhysiologicaSinica. 2008, Oct. Suppl. 1:99.
14. YANG Zhen-yu; GUO Wei; WU Dong-yuan; DU Zhi-min. Study on Extraction,Isolation and Anti-tumor Activity of Daphnoretin from Wikstroemiaindica. Natural Product Research and Development 2008,20(03):522-526.
15. GUO Wei, YANG Lei, WANG Chun-hua, HUO Rong, DU Zhi-min. Culture of vascular smooth muscle cells from coronary arteries of diabetic rats. Chinese Pharmacological Bulletin. 2007,23(01):127-130.

 


 

 
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