魏邦国
天然药物化学, 研究员, 博士生导师

姓      名

 魏邦国

性      别

 男

职      称

 研究员

学      历

 研究生

电      话

 13611780559

传      真

 

电子邮件

 bgwei1974@fudan.edu.cn

个人主页

 

通讯地址

 上海市徐汇区东安路130号西13号楼318  


教育经历 1994.09 – 1998.07 西北师范大学化学系
1998.09 – 2001.07 西北师范大学化学化工学院 有机化学专业   硕士研究生
2001.09 – 2004.09 厦门大学化学化工学院 有机化学专业   博士研究生

工作经历 2004.10 – 2006.08 中国科学院上海有机化学研究所,博士后
2006.8 – 2015.06 复旦大学化学系,副研究员
2015.06 –今 复旦大学药学院,副研究员,研究员

 

研究方向

1. 基于廉价资源,开展具有重要生理活性天然产物的不对称合成方法学研究;

2. 以活性为导向,开展若干复杂海洋天然产物的多样性合成研究;

3. 以稀有中药为目标,开展中药活性成分的化学合成工艺及新药开发研究


主要科研贡献
以活性天然产物的多样性合成为导向,取得了如下研究结果:
1. 首次发现了官能化烷基锌试剂促进的叔丁基S-C 1,3-迁移新反应,建立了取代叔亮氨酸的高效合成方法。
2. 建立了邻位诱导的串联反应合成羟基哌啶、吡咯酰(亚)胺高效合成方法,并用于多个诸如HyacinthacineA1, (+)-Febrifugine, (-)-Nemonapride, (-)-Deoxoprosophylline, (+)-CP-99,994, Hapalosin, (-)-Epiquinamide, (-)-Swainsonine, epohelmins, Agelasphine-9b等多个具有重要生理活性天然产物及药物分子不对称合成。 
3. 基于廉价氨基酸资源,发展了多个诸如Apratoxins, Lagunamides, Emericellamides, Hoiamides,Symplocin A, Tubulusins, Dolastatins等复杂海洋(环)肽酯的多样性合成方法。 
4. 从新药研发的角度出发,建立了具有强抑制肿瘤转移活性的苦马豆素、具有抗疟活性常山碱、抗癌活性常山酮、海兔毒素及抗病毒活性一枝蒿酮酸的实验室小试合成新工艺路线。3个天然产物及类似物的合成新工艺与企业合作或转让用于1类新药的研发。

 

承担科研项目情况
1. 国家自然科学基金面上项目:
① 基于抗体药物偶联物弹头的具有抗肿瘤活性海洋天然产物Hoiamides A、Lyngbyabellin N等的多样性研究(21472022);
② 具有重要生理活性海洋环肽酯Lagunamide、Apratoxins及其氟代类似物的合成和活性评价研究 (21272041);
③具有抗癌活性海洋天然产物Leiodelide A、B 及其类似物全合成和生理活性评价研究 (21272041)
④ 新型抗凝血酶抑制剂的合成 (20702007)
2. 国家自然科学基金重点项目:
重要生理活性天然产物的结构多样性合成研究 (20832005, 复旦子课题负责人,总课题由厦门大学黄培强教授主持)
 
获奖及荣誉

2015.12   上海市药学会科技奖 三等奖(第二完成人)

2012.05    第二十四届上海市优秀发明选拔赛优秀发明 金奖 (第二完成人)
2011.12   上海市药学会科技奖 二等奖(第二完成人)
2011.07   中国药学会科技奖 二等奖(第七完成人)
2010.12   上海市药学会科技奖 二等奖(第七完成人)
2005.04   甘肃省科技进步奖   二等奖  (第七完成人)
2004.07   甘肃省高校科技进步奖 一等奖   (第七完成人)
2002.10   甘肃省高校科技进步奖 二等奖   (第五完成人)


 
代表性论著

1. Lu-Ping Shao, Chang-Mei Si, Zhuo-Ya Mao, Wen Zhou, Tadeusz F Molinski,* Bang-Guo Wei* and Guo-Qiang Lin  Synthesis and Structure Revision of Symplocin A Org. Chem. Front. 2017, 4  DOI: 10.1039/c7qo00052a; 
2. Zhuo-Ya Mao, Chang-Mei Si, Yi-Wen Liu, Han-Qing Dong, Bang-Guo Wei* and Guo-Qiang Lin Asymmetric Synthesis of Apratoxin E J. Org.Chem. 2016, 81, 9903-9911;
3. Chang-Mei Si, Zhuo-Ya Mao, Han-Qing Dong, Zhen-Ting Du, Bang-Guo Wei* and Guo-Qiang Lin Divergent Method to trans-5-Hydroxy-6-alkynyl/alkenyl-2-piperidinones: Syntheses of (-)-Epiquinamide and (+)-Swainsonine  J. Org. Chem. 2015, 80, 5824-5833;
4. Chang-Mei Si, Zhuo-Ya Mao, Yi-Wen Liu, Zhen-Ting Du, Bang-Guo Wei* and Guo-Qiang Lin Stereoselective Formation of Chiral trans-4-Hydroxy-5-Substituted 2-Pyrrolidinones: Syntheses of Streptopyrrolidine and 3-epi-Epohelmin A Org. Chem. Front. 2015, 2, 1485-1499;
5. Chang-Mei Si, Wei Huang, Zhen-Ting Du, Bang-Guo Wei* and Guo-Qiang Lin Diastereoconvergent Synthesis of trans-5-Hydroxy-6-Substituted-2-Piperidinones by Addition-Cyclization-Deprotection Process Org. Lett. 2014, 16, 4328-4331;
6. Wei Huang, Jian-Liang Ye, Wei Zheng, Han-Qing Dong, Bang-Guo Wei* Radical Migration?Addition of N-tert-Butanesulfinyl Imines with Organozinc Reagents J. Org. Chem. 2013, 78, 11229-11237;
7. Wei Huang, Rong-Guo Ren, Han-Qing Dong, Bang-Guo Wei* and Guo-Qiang Lin Diverse Synthesis of Marine Cyclic Depsipeptide Lagunamide A and Its Analogues J. Org. Chem. 2013, 78, 10747-10762;
8. Chang-Mei Si, Lu-Ping Shao, Zhuo-Ya Mao, Wen Zhou and and Bang-Guo Wei* An efficient approach to trans-4-hydroxy-5-substituted 2-pyrrolidinones through a stereoselective tandem Barbier process: divergent syntheses of (3R,4S)-statines, (+)-preussin and (-)-hapalosin Org. Biomol. Chem. 2017, 15, 649-661;
9. Yi-Wen Liu, Zhuo-Ya Mao, Rui-Jun Ma, Jia-Hang Yan, Chang-Mei Si* and Bang-Guo Wei* Divergent syntheses of L-733, 060 and CP-122721 from functionalized pieridinones made by one-pot tandem cyclization Tetrahedron 2017, 73, 2100-2108;
10. Yi-Wen Liu, Pan Han, Wen Zhou, Zhuo-Ya Mao, Chang-Mei Si*, Bang-Guo Wei* Asymmetric syntheses of epohelmins A and B by In-mediated allylation Org. Biomol. Chem. 2016, 14, 10714-10722;
11. Chang-Mei Si, Yi-Wen Liu, Zhuo-Ya Mao, Pan Han, Zhen-Ting Du, Bang-Guo Wei* Asymmetric synthesis of epohelmins A, B 3-epi ent-epohelmin A Tetrahedron 2016, 72, 8091-8098;
12. Ming Li, Pan Han, Zhuo-Ya Mao, Wen Zhou, Chang-Mei Si, Juan Xiong*, Bang-Guo Wei*, Jin-Feng Hu Studies toward synthesis of hoiamides A B Tetrahedron Lett. 2016, 57, 5620-5623;
13. Wei Tao, Wen Zhou, Zhu Zhou, Chang-Mei Si*, Xun Sun, Bang-Guo Wei* An enantioselective total synthesis of tubulysin V Tetrahedron 2016, 72, 5928-5933;
14. Xiao-Xing Huang, Wei Huang, Li Li, Xi-Huan Sun, Si-Yang Song, Qing-Yan Xu, Lian-Ru Zhang, Bang-Guo Wei, Xian-Ming Deng* Structure Determinants of Lagunamide A for Anticancer Activity and Its Molecular Mechanism of Mitochondrial Apoptosis Mol. Pharmaceutics 2016, 13, 3756-3763;
15. Chang-Mei Si, Zhuo-Ya Mao, Zhu Zhou, Zhen-Ting Du*, Bang-Guo Wei* Divergent synthesis of L-685,458 and its analogues involving one-pot intramolecular tandem sequence reaction Tetrahedron 2015, 71, 9396-9402;
16. Chang-Mei Si, Zhuo-Ya Mao, Rong-Guo Ren, Zhen-Ting Du*, Bang-Guo Wei* Flexible approach for the synthesis of (-)-hyacinthacine A1 and its 7a-epimer Tetrahedron 2014, 70, 7936-7941;
17. Rong-Guo Ren, Ming Li, Chang-Mei Si, Zhuo-Ya Mao and Bang-Guo Wei* Studies toward asymmetric synthesis of leiodelide A Tetrahedron Lett. 2014, 55, 5285-5292;
18. Qian-Ru Zhou, Xiao-Yun Wei, You-Qin Li, Danfeng Huang*, Bang-Guo Wei* An efficient method for the preparation of 3-hydroxyl-5-substituted 2-pyrrolidones and application in the divergent synthesis of (-)-preussin and its analogues Tetrahedron 2014, 70, 4799-4808.



 

 

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