熊娟
天然药物化学, 副教授

姓      名

熊娟

性      别

职      称

副教授/硕士生导师

学      历

博士

电      话

021-51980171

传      真

  

电子邮件

 jxiong@fudan.edu.cn

个人主页

   

通讯地址

张衡路826号化学楼北楼417


教育经历 2001.09 – 2005.06 武汉大学药学院(本科,药学专业)
2005.09 – 2007.06 武汉大学药学院(硕士,药物化学专业)
2007.10 – 2010.09 日本德島大学药学部(博士,天然药物化学专业)
 
工作经历 2016.12 – 至今       复旦大学药学院天然药物化学教研室,副教授

2011.05 – 2016.11  复旦大学药学院天然药物化学教研室,讲师

承担的主要科研项目
1. 国家自然科学基金面上项目,四种中国特有金粟兰属植物中新颖萜类化学成分的发现及其结构与生物功能研究(No. 21772025,2018/01-2021/12,64万元,主持)
2. 国家自然科学基金青年基金项目,樗白皮逆转P-gp介导肿瘤细胞多药耐药的物质基础研究(No. 81202420,2013/01 2015/12,23万元,主持)
3. 教育部博士点新教师基金,金丝条马尾杉中石松类生物碱及其神经营养活性(No. 20120071120049,2013/01 2015/12,4万,主持)

4. 国家自然科学基金面上项目,四种石松科植物新型生物碱成分及其抗阿尔茨海默症活性研究(No.  21472021,2015/01-2018/12,90万元,参与)


研究方向

开展我国特有植物来源的新颖萜类和生物碱类成分的快速发现及其生物功能多样性研究;围绕神经系统退行性疾病,开展新型活性天然产物的发现、结构鉴定与优化及作用机理研究。

 

代表性论著



近年已在本领域权威或重要学术期刊上发表论文60余篇,其中第一或通讯作者论文30篇(含SCI论文29篇),申请并授权中国发明专利6项。部分代表性论文列举如下:

[1]  Xiong Juan#, Jiang Wan#, Jie Ding, Pei-Pei Wang, Guang-Lei Ma, Li Jia, Hu Jin-Feng*, Camellianols A-G, barrigenol-like triterpenoids with PTP1B inhibitory effects from the endangered ornamental plant Camellia crapnelliana, Journal of Natural Products 2017, 80: 2874-2882.    (# co-first author)                                    
[2] Tang Yu#, Xiong Juan#, Zhang Jing-Jing, Wei-Wang, Zhang Hai-Yan*, Hu Jin-Feng*. Annotinolides A-C, three lycopodane-derived 8,5-lactones with polycyclic skeletons from Lycopodium annotinum. Organic Letters 2016, 18: 4376-4379. (# co-first author)
[3]  Xiong Juan, Hong Zhi-Lai, Xu Peng, Zou Yike, Yu Shang-Bo, Yang Guo-Xun, Hu Jin-Feng*. ent-Abietane diterpenoids with anti-neuroinflammatory activity from the rare Chloranthaceae plant Chloranthus oldhamii, Organic & Biomolecular Chemistry 2016, 14: 4678-4689.
[4]  Hu Chang-Ling#, Xiong, Juan#, Gao Li-Xin, Li Jia, Zeng Huaqiang, Zou Yike, Hu Jin-Feng*. Diterpenoids from the shed trunk barks of the endangered plant Pinus dabeshanensis and their PTP1B inhibitory effects. RSC Advances 2016, 6: 60467-60478. (# co-first author)
[5]  Hu Chang-Ling#, Xiong Juan#, Li Ji-Yang, Gao Li-Xin, Wang Wen-Xuan, Cheng Ke-Jun, Yang Guo-Xun, Li Jia, Hu Jin-Feng*. Rare sesquiterpenoids from the shed trunk barks of the critically endangered plant Abies beshanzuensis and their bioactivities. European Journal of Organic Chemistry 2016: 1832-1835. (# co-first author)
[6]  Xiong Juan, Huang Ya, Wu Xi-Ying, Liu Xin-Hua, Fan Hui, Wang Wei, Zhao Yun, Yang Guo-Xun, Zhang Hai-Yan, Hu Jin-Feng*, Chemical constituents from the fermented mycelia of the medicinal fungus Xylaria nigripes. Helvetica Chimica Acta 2016, 99: 83-89.
[7] Wu Xi-Ying, Xiong Juan*, Liu Xin-Hua, Hu Jin-Feng, Chemical constituents from the rare cliffplantOrestitrophe rupifraga and their anti-nueroinflammatory activity. Chemistry & Biodiversity 2016, 13: 1030–1037. 
[8]  Tang Yu, Xiong Juan*, Zou Yike, Zhang Hai-Yan, Hu Jin-Feng*, Palhicerines A–F, Lycopodium alkaloids from the club moss Palhinhaea cernua. Phytochemistry 2016, 131: 130-139. 
[9] Meng Wei-Jia, Xiong Juan*, Wang Wen-Xuan, Zhang Hai-Yan, Zeng Hua-Qiang, Hu Jin-Feng*, Phlefargesiine A, a C16N2 Lycopodium alkaloid with an unprecedented [6/7/6/6]-tetracyclic skeleton fromPhlegmariurus fargesii. Tetrahedron Letters 2016, 57, 3218-3221.
[10]  Xiong Juan, Hong Zhi-Lai, Gao Li-Xin, Shen Jie, Liu Shu-Ting, Yang Guo-Xun, Li Jia*, Zeng Huaqiang, Hu Jin-Feng*. Chlorabietols A-C, Phloroglucinol-diterpene adducts from the Chloranthaceae Plant Chloranthus oldhamii. Journal of Organic Chemistry 2015, 80: 11080-11085.
[11]  Xiong Juan, Bui Van-Binh, Liu Xin-Hua, Hong Zhi-Lai, Yang Guo-Xun, Hu Jin-Feng*. Lignans from the stems of Clematis armandii (“Chuan-Mu-Tong”) and their anti-neuroinflammatory activities. Journal of Ethnopharmacology 2014, 153: 737-743.
[12]  Xiong Juan, Liu Xin-Hua, Bui Van-Binh, Hong Zhi-Lai, Yang Guo-Xun, Hu Jin-Feng *. Phenolic constituents from the leaves of Cratoxylum formosum ssp. pruniflorum. Fitoterapia 2014, 94:114-119.
[13]  Hong Zhi-Lai, Juan Xiong*, Shi-Biao Wu, Jing-Jing Zhu, Jun-Lin Hong, Yun Zhao, Gang Xia, Jin-Feng Hu*. Tetracyclic triterpenoids and terpenylated coumarins from the bark of Ailanthus altissima (“Tree of Heaven”). Phytochemistry 2013, 86: 159-167.
[14]  Xiong Juan, Liu Shu-Ting, Tang Yu, Wang Wen-Xuan, Bui Van-Binh, Zhao Yun, Fan Hui, Yang Guo-Xun, Hu Jin-Feng *. Sesquiterpenoids from the aerial parts of Chloranthus elatior. Phytochemistry Letters 2013, 6: 586-589.






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