李炜
药物化学, 副教授


姓      名

李炜

性      别

职      称

副教授

学      历

博士

电      话

021-51980122

传      真

021-51980122

电子邮件

wei-li@fudan.edu.cn

个人主页


通讯地址

上海市浦东新区张衡路826号


教育经历



1998.9-2002.7  复旦大学药学院药学专业本科
2002.9–2005.7 复旦大学药学院药物化学教研室硕士研究生
2005.9-2007.7  复旦大学药学院药物化学教研室博士研究生



工作经历



2016.12 – 至今        复旦大学药学院,副教授

2012.10– 2013.10   美国哈佛医学院麦可林医院(McLean Hospital),访问学者

2007.7 – 2016.11    复旦大学药学院,讲师



研究方向   



1. 阿片受体配基及相关中枢神经系统疾病治疗药物的研究

2. 基于pDOS策略的多样性类药化合物库的设计与开发
 
代表性论著


1. Wei Li#, Jian-Dong Long#, Yuan-Yuan Qian#, Yu Long, Xue-Jun Xu, Yu-Jun Wang, Qing Shen, Zuo-Neng Wang, Xi-Cheng Yang, Li Xiao, Hong-Peng Sun, Yu-Long Xu, Yi-Yi Chen, Qiong Xie, Yong-Hui Wang, Li-Ming Shao, Jing-Gen Liu*, Zhui-Bai Qiu, Wei Fu*. The pharmacological heterogeneity of nepenthone analogs in conferring highly selective and potent kappa-opioid agonistic activities. ACS Chem NeuroSci, 2017, 8 (4), 766–76.


2. Jian Shen#, Xi-cheng Yang#, Ming-cheng Yu, Li Xiao, Xun-jie Zhang, Hui-jiao Sun, Hao Chen, Guan-xin Pan, Yu-rong Yan, Si-chen Wang, Wei Li*, Lu Zhou*, Qiong Xie, Lin-qian Yu, Yong-hui Wang, Li-ming Shao*. Discovery, synthesis, biological evaluation and structure-based optimization of novel piperidine derivatives as acetylcholine-binding protein ligands. Acta Pharmacol Sin, 2017, 38(1): 146-55. 

3. Yulong Xu, Yi-yi Chen, Wei Li, Qiong Xie, Liming Shao*. Microwave-assisted synthesis of phenanthridines by radical insertion/cyclization of biphenyl isocyanides. J Org Chem, 2016, 81: 8426-35.

4. Wei Li#, Jian Wu#, Lili Xu#, Peng Du, Xuechu Zhen*, Wei Fu*. Functional reversal of (-)-Stepholidine analogues by replacement of benzazepine substructure using the ring-expansion strategy, Chem Biol Drug Des, 2016, 88(4), 599-607.

5. Qing Shen, Yuanyuan Qian, Xiaoqin Huang, Xuejun Xu, Wei Li*, Jinggen Liu*, and Wei Fu*. Discovery of potent and selective agonists of delta opioid receptor by revisiting the “Message-Address” concept. ACS Med Chem Lett, 2016, 7 (4), 391–6.

6. Qing Shen, Yuan-yuan Qian, Xue-jun Xu, Wei Li*, Jing-gen Liu*, Wei Fu*. Design, synthesis and biological evaluation of N-phenylalkyl-substituted tramadol derivatives as novel mu opioid receptor ligands. Acta Pharmacol Sin, 2015, 36: 887-94.

7. Yulong Xu, Qiong Xie, Wei Li, Hongpeng Sun, Yonghui Wang, Liming Shao*, A convenient aqueous copper-catalyzed synthesis of quinazolinones. Tetrahedron, 2015, 72(29):4853-8.

8. Anna W. Sromek, Shaohui Zhang, Vamsidhar Akurathi, Alan B. Packard, Wei Li, David Alagille, Thomas J. Morley, Ronald Baldwin, Gilles Tamagnan, John L. Neumeyer*. Convenient synthesis of 18F-radiolabeled R-(-)-N-n-propyl-2-(3- fluoropropanoxy-11-hydroxy noraporphine. J Labelled Compd Radiopharm, 2014, 57(14):725-9.

9. Brian A. Provencher, Anna W. Sromek, Wei Li, Shayla Russell, Elena Chartoff, Brian I. Knapp, Jean M. Bidlack, John L. Neumeyer*. Synthesis and pharmacological evaluation of aminothiazolo morphinans at the mu and kappa opioid receptors. J Med Chem, 2013, 56, 8872-8.

10. Wei Li#, Li-li Xu#, Qiong Xie, Yan Chen, Mei-yan Lu, Bo Chao, Xing-hai Wang, Yun Tang, Zhui-bai Qiu, Wei Fu* & Choiwan Lau*, Theoretical and NMR investigations on the conformations of (-)-meptazinol hydrochloride in solution, Mol Simulat, 2013, 39(13),1065-9.



 


打印 返回