刘新华
药理学与生物化学, 副研究员, 硕士生导师

姓      名

 刘新华

性      别

 女

职      称

 副研究员

学      历

 博士

电      话

 021-51980159

传      真

 021-51980159

电子邮件

 liuxinhua@fudan.edu.cn

个人主页

 

通讯地址

 上海市浦东新区张衡路826号科研楼417

教育经历

2006/07-2009/07, 复旦大学药学院,医学博士;

2000/09-2003/07, 中国医科大学药理学教研室硕士研究生,医学硕士学位;

1994/09-1999/07, 内蒙古医学院医学系, 医学学士学位;

 

工作经历

2013/12-至今,复旦大学药学院药理教研室,副研究员、硕士生导师;

2009/7-2013/11,复旦大学药学院药理教研室,讲师;

2003/07-2006/09,上海市安图医院,临床药师;


研究方向

心血管分子药理

 

主持科研项目

1. NSFC面上项目,Nox4调控VSMC衰老在动脉粥样硬化中的作用研究(№: 81470164 )

2. NSFC青年基金项目,益母草碱抗动脉粥样硬化作用及其机制(№: 81102435)

3. 上海市科委重点项目,具有独特心血管保护作用一类新药益母草碱的临床前研究(№: 10431900100 )

4. 中央高校青年教师科研能力提升项目,Nox4/ROS在血管重构中的作用及机制研究(№: 20520133185)

5. 复旦大学新教师基金,益母草碱对缺血心肌保护作用的抗炎机制研究

 

获奖

1. 刘新华,中国药理学会,青年药理学工作者奖,2011.09;

2. 朱依谆,刘新华, 等,科学中药理念的开发新药的研究,上海市药学会科技奖二等奖,2013.12;

3. 朱依谆,刘新华, 等,1类新药SCM-198(益母草碱)药效学研究和临床前开发,中国药学会科技奖三等奖,2011.07;

4. 朱依谆,刘新华, 等,具有独特心脑血管保护作用的一类新药益母草碱(SCM-198)的临床前研究,上海市药学会科技奖二等奖,2010.12;

 

代表性论文

目前在Antioxid Redox Signal、Free Radic Biol Med、Int J Cardiol、BBA、Athersclerosis等国际学术知名期刊上以第一作者/通讯作者发表了20余篇SCI论文

[1] Liu X, Pan L, Gong Q, Zhu Y. Leonurine (SCM-198) improves cardiac recovery in rat during chronic infarction. Eur J Pharmacol 2010; 649(1-3):236-41.

[2] Liu X, Pan L, Wang X, Gong Q, Zhu YZ. Leonurine protects against tumor necrosis factor-alpha-mediated inflammation in human umbilical vein endothelial cells. Atherosclerosis 2012; 222(1):34-42.

[3] Liu X, Pan L, Zhuo Y, Gong Q, Rose P, Zhu Y. Hypoxia-inducible factor-1alpha is involved in the pro-angiogenic effect of hydrogen sulfide under hypoxic stress. Biol Pharm Bull 2010; 33(9):1550-4.

[4] Liu XH, Chen PF, Pan LL, Silva RD, Zhu YZ. 4-Guanidino-n-butyl syringate (Leonurine, SCM 198) protects H9c2 rat ventricular cells from hypoxia-induced apoptosis. J Cardiovasc Pharmacol 2009; 54(5):437-44.

[5] Liu XH, Pan LL, Chen PF, Zhu YZ. Leonurine improves ischemia-induced myocardial injury through antioxidative activity. Phytomedicine 2010; 17(10):753-9.

[6] Liu XH, Pan LL, Deng HY, Xiong QH, Wu D, Huang GY, et al. Leonurine (SCM-198) attenuates myocardial fibrotic response via inhibition of NADPH oxidase 4. Free Radic Biol Med 2013; 54:93-104.

[7] Liu XH, Pan LL, Gong QH, Zhu YZ. Antiapoptotic effect of novel compound from Herba leonuri - leonurine (SCM-198): a mechanism through inhibition of mitochondria dysfunction in H9c2 cells. Curr Pharm Biotechnol 2010; 11(8):895-905.

[8] Liu XH, Pan LL, Jia YL, Wu D, Xiong QH, Wang Y, et al. A novel compound DSC suppresses lipopolysaccharide-induced inflammatory responses by inhibition of Akt/NF-kappaB signalling in macrophages. Eur J Pharmacol 2013; 708(1-3):8-13.

[9] Liu XH, Pan LL, Yang HB, Gong QH, Zhu YZ. Leonurine attenuates lipopolysaccharide-induced inflammatory responses in human endothelial cells: involvement of reactive oxygen species and NF-kappaB pathways. Eur J Pharmacol 2012; 680(1-3):108-14.

[10] Liu XH, Pan LL, Zhu YZ. Active chemical compounds of traditional Chinese medicine Herba Leonuri: implications for cardiovascular diseases. Clinical & Experimental Pharmacology & Physiology 2012; 39(3):274-82.

[11] Liu XH, Xin H, Hou AJ, Zhu YZ. Protective effects of leonurine in neonatal rat hypoxic cardiomyocytes and rat infarcted heart. Clinical & Experimental Pharmacology & Physiology 2009; 36(7):696-703.

[12] Pan LL*, Liu XH*, Gong QH, Wu D, Zhu YZ. Hydrogen sulfide attenuated tumor necrosis factor-alpha-induced inflammatory signaling and dysfunction in vascular endothelial cells. PLoS One 2011; 6(5):e19766. (co-first author)

[13] Pan LL*, Liu XH*, Gong QH, Yang HB, Zhu YZ. Role of cystathionine gamma-lyase/hydrogen sulfide pathway in cardiovascular disease: a novel therapeutic strategy? Antioxid Redox Signal 2012; 17(1):106-18. (co-first author)

[14] Pan LL*, Liu XH*, Jia YL, Wu D, Xiong QH, Gong QH, et al. A novel compound derived from danshensu inhibits apoptosis via upregulation of heme oxygenase-1 expression in SH-SY5Y cells. Biochim Biophys Acta 2013; 1830(4):2861-71. (co-first author)

[15] Pan LL*, Liu XH*, Shen YQ, Wang NZ, Xu J, Wu D, et al. Inhibition of NADPH oxidase 4-related signaling by sodium hydrosulfide attenuates myocardial fibrotic response. Int J Cardiol 2013; 168(4):3770-8. (co-first author)

[16] Pan LL*, Liu XH*, Zheng HM, Yang HB, Gong QH, Zhu YZ. S-propargyl-cysteine, a novel hydrogen sulfide-modulated agent, attenuated tumor necrosis factor-alpha-induced inflammatory signaling and dysfunction in endothelial cells. Int J Cardiol 2012; 155(2):327-32. (co-first author)

[17] Xiong J, Bui VB, Liu XH#, Hong ZL, Yang GX, Hu JF#. Lignans from the stems of Clematis armandii ("Chuan-Mu-Tong") and their anti-neuroinflammatory activities. J Ethnopharmacol 2014; 153(3):737-43. (co-corresponding Author)

[18] Zhong C*, Liu XH*, Chang J, Yu JM, Sun X. Inhibitory effect of resveratrol dimerized derivatives on nitric oxide production in lipopolysaccharide-induced RAW 264.7 cells. Bioorg Med Chem Lett 2013; 23(15):4413-8. (co-first author)

[19] Zhong C*, Liu XH*, Hao XD, Chang J, Sun X. Synthesis and biological evaluation of novel neuroprotective agents for paraquat-induced apoptosis in human neuronal SH-SY5Y cells. Eur J Med Chem 2013; 62:187-98.(co-first author)

 

社会兼职

中国药理学会心血管药理专业委员会委员


 

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