刘洪瑞
药理学与生物化学, 副教授, 硕士生导师

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个人简历       1991年毕业于第二军医大学临床医学专业,2005年获中国医科大学药理学博士学位。 2007年加入复旦大学任讲师、副教授。主要从事药理学教学工作,主要研究方向为心血管及肿瘤药理学。参编普通高等教育“十五”国家级规划教材《临床药理学》第3版和“十一五”国家级规划教材《药物毒理学》第2版。主持科技部重大新药创制“综合性新药研究开发技术大平台”子项目1项和上海市科委“中药现代化”1 项,申请发明专利3项,发表论文20余篇。曾获上海市药监局“上海市首届执业药师继续教育金牌教师”、“上海药学科技奖”二等奖。 

 

代表性论著

1.   Liu HR, Meng LY, Lin ZY, et al. Cochinchina Momordica Seed Extract Induces Apoptosis and Cell Cycle Arrest in Human Gastric Cancer Cells Via PARP and p53 Signal Pathways. Nutrition and Cancer. 2012, 64(7), 1070–7

2.   Chen Y*, Liu HR*, Liu HS, et al. Antitumor agents 292. Design, synthesis and pharmacological study of S- and O-substituted 7-mercapto- or hydroxy-coumarins and chromones as potent cytotoxic agents. Eur J Med Chem. 2012; 49: 74-85. (*co-first author )3.   Meng LY*, Liu HR*, Shen Y, et al. Cochinchina momordica seed extract induces G2/M arrest and apoptosis in human breast cancer MDA-MB-231 cells by modulating the PI3K/Akt pathway. Asian Pac J Cancer Prev. 2011; 12(12): 3483-8. (*co-first author )

4.   Zheng Y*, Liu H*, Ma G, et al. Determination of S-propargyl-cysteine in rat plasma by mixed-mode reversed-phase and cation-exchange HPLC-MS/MS method and its application to pharmacokinetic studies. J Pharm Biomed Anal. 2011; 54(5): 1187-91. (*co-first author )

5.   Wang Q*, Liu H*, Liu T, et al. BRCA2 Dysfunction Promotes Malignant Transformation of Pancreatic Intraepithelial Neoplasia. Anticancer Agents Med Chem. Anticancer Agents Med Chem. 2013; 13(2): 261-9. (*co-first author )

6.   Hongrui Liu*, Guangzhi Bao*, Suna Yang, et al. Synthesis and evaluation of tetrahydro βcarboline derivatives as anticancer agents. Journal of Chinese Pharmaceutical Sciences. 2012; 21: 416-420 (*co-first author )

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