楼滨
药理学与生物化学, 副教授, 硕士生导师

姓      名

 楼滨

性      别

 

职      称

 副教授

学      历

 博士

电      话

 021-51980032

传      真

 021-51980032

电子邮件

个人主页

 

通讯地址

 上海市浦东新区张衡路826号科研楼

教育经历

1979,09-1983,07   上海医科大学药学院药化专业,学士
1986,09-1989,07   上海医科大学药学院放射化学专业,硕士
2000,09-2005,03   复旦大学药学院生物化学和分子生物学专业,博士


工作经历 1983,8-1986,7    江苏省原子医学所工作
1989,8-2007,2    复旦大学药学院生物化学教研室任讲师、副教授
2007,3-2010,5    美国艾默里(Emory University)大学药理系进修
2010,6-至今    复旦大学药学院工作,现任药学院药理生化教研室副教授,副主任

 

      主要从事鞘磷脂与脂蛋白代谢、动脉粥样硬化及其炎症等研究。曾研发抗血栓药物-低分子肝素,并转让给企业,获四类新药证书。参与“载脂蛋白A-I的抗内毒素、抗炎症新功能研究及人载脂蛋白A-I的基因工程制备”获2004年上海市药学会颁发的上海药学成果奖二等奖。
      2007年到2010年在美国Emory大学药理系进修,用高通量筛选技术筛选ASK1炎症信号通路抑制剂,并研究这些化合物抗ASK1炎症通路的作用机理。用高内涵筛选技术研究curcumin及其衍生物抗肿瘤作用。
参与人民卫生出版社出版的全国高等学校教材“药学分子生物学”第二,第三,第四版,第五版编写。

 

科研成果

1. Bin Lou*, Jibin Dong., Yali Li, Tingbo Ding, Tingting Bi, Yue Li, Xiaodong Deng, Deyong Ye, Xian-Cheng Jiang.Pharmacologic Inhibition of Sphingomyelin Synthase(SMS) Activity Reduces Apolipoprotein-B Secretion from Hepatocytes and Attenuates Endotoxin-Mediated Macrophage Inflammation. PLoS ONE 9(7): e102641,2014
2. Xiaodong Deng, Fu Lin, Ya Zhang, Yan Li, Lu Zhou, Bin Lou*, Yue Li, Jibin Dong, Tingbo Ding, Xiancheng Jiang, Renxiao Wang,Deyong Ye. Identification of small molecule sphingomyelin synthase inhibitors. European Journal of Medicinal Chemistry,  73(12), 1–7, 2014
3. Tingbo Ding  , Jibin Dong  , Bin Lou*  , XianCheng Jiang. Sphingomyelin synthase activity measurement by the fluorescent product in cell culture medium or animal plasma. J. Chin. Pharm. Sci. 2014, 23 (4), 256–261
4. Guo-Xun Yang, Rui-Ze Zhang, Bin Lou*, Ke-Jun Cheng, Juan Xiong & Jin-Feng Hua. Natural Product Research: Formerly Natural Product Letters  Volume 28, Issue 17, 2014 , pages 1383-1387Chemical constituents from Melastoma dodecandrum and their inhibitory activity on interleukin-8 production in HT-29 cells.
5.  Yuhong Du, Robert W. Fu,Bin Lou*,Jing Zhao,Min Qui, Fadlo R. Khuri, and Haian Fu. A Time-Resolved Fluorescence Resonance EnergyTransfer Assay for High-Throughput Screening. ASSAY and Drug Development Technologies .11 ( 6)  ,367-381, 2013.
6. Jing Zhao, Yuhong Du, John Horton, Anup Upadhyay, Bin Lou*, Xing Zhang, Lupei Du, Minyong Li, Binghe Wang, Lixin Zhang, Joseph Barbieri, Fadlo Khuri, Xiaodong Cheng, and Haian Fu. Discovery and structural characterization of a small molecule 14-3-3 protein-protein interaction inhibitor. PNAS 108 (39 ) 16212–16216, 2011 .
7. Xu Qiu, Yuhong Du, Bin Lou*, Yinglin Zuo, Weiyan Shao, Yingpeng Huo, Jianing Huang, Yanjun Yu, Binhua Zhou. Jun Du, Haian Fu,and Xianzhang Bu. Synthesis and Identification of New 4-Arylidene Curcumin Analogues as Potential Anticancer Agents Targeting Nuclear Factor-KB Signaling Pathway. J. Med. Chem. 53, 8260–8273, 2010.
8. Thomas Shala L; Zhao Jing; Li Zijian; Lou Bin*; Du Yuhong; Purcell Jamie; Snyder James P; Khuri Fadlo R; Liotta Dennis; Fu Haian. Activation of the p38 pathway by a novel monoketone curcumin analog, EF24, suggests a potential combination strategy. Biochemical pharmacology. 80(9):1309-1316, 2010

 

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