卢懿
药剂学, 副教授, 硕士生导师

姓      名

卢懿

性      别

职      称

副教授

学      历

研究生

电      话

021-51980084

传      真

021-51980084

电子邮件

fd_luyi@fudan.edu.cn

个人主页


通讯地址

   上海市张衡路826号复旦大学药学院科研楼729

教育经历 2001.09 – 2006.07 四川大学华西药学院药学专业,博士
1997.09 – 2001.07 四川大学华西药学院药剂专业,本科
 
工作经历 2011.09 –  复旦大学药学院,副教授
2014.03 – 2015.03 美国普渡大学(Purdue University),访问学者
2006.07 – 2011.08 复旦大学药学院,讲师
 

专家类别副教授

 

职务硕士生导师

 

承担科研项目情况
1. 国家自然科学基金, 温度敏感内部胶凝化脂质体的研究(30801440)
2. 教育部高等学校博士点基金新教师项目, 纳米立方液晶促进难溶性药物口服吸收机理的研究(200802461092)
3. 上海市科委科技发展基金,前体纳米胶束促进难溶性药物口服吸收的研究(0852nm04400,主持);固态化纳米乳剂的研制及促进难溶性药物口服吸收的机制研究(0952nm03200,参与);载脂蛋白A-I介导的重组HDL纳米粒肝靶向性及其机制研究(0952nm03500,参与)
4. 国家重大新药创制专项, 1类化学类新药吡咯喹啉醌三锂防治阿尔茨海默病的临床前研究(2011ZX09102-003-04),参与(负责制剂部分研究)
5. Novo Nordisk A/S合作研究项目,Solid dispersion of polypeptides: enhanced formulation stability and oral bioavailability of insulin (参与)
6. F. Hoffmann-La Roche Ltd合作研究项目,Lymphatic absorption by the oral route: rationale design of delivery systems exemplified by self-microemulsifying and micellar drug delivery systems (参与)

 

研究方向
1.药物的口服递送
2. 制剂新技术
 
科研成果
在构建新型纳米给药系统构促进药物口服递送及制剂新技术的工业化应用方面开展了系列研究,并取得一定进展,主要包括:
1. 设计并构建GMO立方液晶纳米粒,率先考察其促进难溶性药物口服吸收的作用及机理。所制备的立方液晶纳米粒生物利用度为Neoral®这一公认的环孢素A高生物利用度制剂的1.8倍,这类脂质纳米粒在小肠部位的解聚及脂解是其发挥作用的基础,研究结果为难溶性药物的高口服生物利用度制剂研发提供了新的选择和参考。
2. 利用温度敏感凝胶体系的温敏性质,设计并构建了内部胶凝化脂质体,提高脂质体冷冻干燥过程、室温储存及人体内稳定性,与此同时,脂质体磷脂双分子层生物相容性好的特点得以保留。
3. 发展流化床小丸上样技术,制备环糊精包合物及固体分散体小丸,所制得小丸直接填充胶囊,“一步”成型;实现自微乳化给药系统、混合胶束制剂等液体制剂的固态化,改善液体制剂固有的不稳定缺陷。相应技术具有良好的工业化应用前景。
4. 基于大部分化合物溶解度具有pH依赖的特点,通过酸碱中和反应,发展酸/碱溶析法制备纳米结晶新技术,可以减小或避免毒性有机溶剂的使用,极具开发潜力。
5. 申请专利2项(授权2项)。
 
社会任职
2015.01 – 现在 《药学研究》编委会,委员
2012.09 – 现在 中国颗粒学会青年理事会,理事
2014.01 – 现在 中国颗粒学会生物颗粒专业委员会,委员
2012.11 – 现在 上海市药理学会皮肤药理学专业委员会,委员
 
代表论著
2010年来, 在J Biomed Nanotech、Nanomedicine (Lond.)、Curr Drug Metab、Int J Pharm、Int J Nanomedcine、J Drug Target等国际刊物发表多篇SCI 论文,代表性论文如下:
1. Yi Lu, Yan Chen, Richard A. Gemeinhart, Wei Wu,Tonglei Li*. Developing Nanocrystals for Cancer Treatment. Nanomedicine (Lond.), in press.
2. XiuliWei, Yi Lu*, JianpingQi, BaojianWu, Jian Chen, HuinanXu, Wei Wu. An in situ crosslinked compression coat comprised of pectin and calcium chloride for colon-specific delivery of indomethacin. Drug Deliv. 2015, 22(3):298-305
3. Yi Lu, YitingQiu, Jianping Qi, Meiqing Feng, DianwenJu, Wei Wu. Biomimetic reassembled chylomicrons as novel association model for the prediction of lymphatic transportation of highly lipophilic drugs via the oral route. Int J Pharm. 2015, 483: 69-76.
4. Lu Y, Tang N, Lian R, Qi J, Wu W. Understanding the relationship between wettability and dissolution of solid dispersion. Int J Pharm. 2014, 465(1-2):25-31.
5. Mette Thing, Yi Lu*, Li ?g?rdh, Claus Larsen, Jesper?stergaard, Wei He, Wei Wu, Frank Larsen, Susan Weng Larsen*. Prolonged naproxen joint residence time after intra-articular injection of lipophilic solutions comprising a naproxen glycolamide ester prodrug in the rat. Int J Pharm 2013, 451(1-2):34-40.
6. Fuxia Dong, Yi Lu*, YunchangXie, Jianping Qi, Fuqiang Hu, Sanming Li*, Wei Wu. Bile salts/phospholipids mixed micelle pellets precursor prepared by fluid-bed coating. Int J Nanomedicine 2013, 8: 1653-1663.
7. Zhongjian Chen, Yi Lu*, Jianping Qi, Wei Wu. Enhanced dissolution, stability and physicochemical characterization of ATRA/2-hydroxypropyl-β-cyclodextrin inclusion complex pellets prepared by fluid-bed coating technique. Pharm Dev Tech 2013, 18(1):130-136.
8. Ying Xu, Xiaoyi Liu, RuyueLian, Siyi Zheng, Zongning Yin, Yi Lu*, Wei Wu. Enhanced dissolution and oral bioavailability of aripiprazolenanosuspensions prepared by nanoprecipitation/homogenization based on acid-base neutralization. Int J Pharm 2012, 438(1-2): 287-295
9. Yan Chen, Yi Lu*, Qingping Wang, YanqiangZhong, Dan Wang, Wei Wu, Shen Gao*. Ocular delivery of cyclosporine A based on glycerylmonooleate/poloxamer 407 cubic nanoparticles: Preparation, characterization, in vitro corneal penetration and ocular irritation. J Drug Target 2012, 20(10):856-863
10. Yi Lu, Tao Guo, Jian-ping Qi, Ji-wen Zhang*, Wei Wu*. Enhanced dissolution and stability of lansoprazole by cyclodextrin inclusion complexation: Preparation, characterization and molecular modeling. AAPS PharmSciTech 2012, 13(4):1222-1229
11. Yang Lei, Jianping Qi, SufangNie, Fuqiang Hu, Weisan Pan*, Yi Lu*, and Wei Wu. Solid self-nanoemulsifyingcyclosporinA pellets prepared by fluid-bed coating: Stability and bioavailability study. J Biomed Nanotech 2012, 8:515-521.
12. Yi Lu, Jianping Qi, Wei Wu*. Absorption, distribution and pharmacokinetics of nanoemulsions. Cur Drug Metab 2012, 13(10):396-417.
13. Yi Lu, Ning Tang, Jianping Qi, Wei Wu*. Phase solubility behavior of hydrophilic polymer/cyclodextrin/lansoprazole ternary system studied at high polymer concentration and by response surface methodology. Pharm Dev Tech 2012, 17(2): 236-241.
14. RuyueLian, Yi Lu, Jianping Qi, Yanan Tan, MengmengNiu, Peipei Guan, Fuqiang Hu, Wei Wu*. SilymarinGlycerylMonooleate/Poloxamer 407 Liquid Crystalline Matrices: Physical Characterization and Enhanced Oral Bioavailability. AAPS PharmSciTech 2011,12(4):1234-1240.
15. Bei Zhang, Yi Lu, Jian Chen, Wei Wu*. Effects of interior gelation on pharmacokinetics and biodistribution of liposomes encapsulating an anti-cancer drug cytarabine. J Biomed Nanotech 2010, 6(6): 704-709.
 
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