高原
临床药学与药事管理, 副研究员

姓      名

 高原

性      别

 女

职      称

 副研究员

学      历

 博士

电      话

 021-51980025

传      真

 

电子邮件

 yuan_gao@fudan.edu.cn

个人主页

 

通讯地址

 上海浦东张衡路826号科研楼东辅楼201室,邮编:201203

 

复旦大学药学院临床药学与药事管理教研室副研究员,药剂学博士。担任上海市科委产业化项目审评专家、上海市浦东新区科技发展基金专家。先后于1995、1998年在沈阳药科大学获得药剂学本科和硕士学位,2009年博士毕业于第二军医大学,2010-2012先后在中科院药物所、加拿大Alberta大学从事博士后研究。曾在上药集团、第二军医大学附属长海医院从事新药研究,也曾在CFDA新药审评中心外聘工作。2017年1月加入复旦大学药学院临床药学与药事管理教研室。主要研究方向为:1)药品政策法规研究;2)新药研发;3)药物靶向治疗研究。


科研成果

1. 项目与专著

主持国家自然基金面上项目 (81672545); 参与国家自然基金面上项目(81672516和 81372762); 主持上海市医院药学研究基金“粘膜下肿瘤标记用三嵌段温敏凝胶的应用”、承担多项上海市科委生物医药产业化基金。作为主编或副主编《滴眼剂的开发与生产》、《药物制剂生产工艺与注解》专著3本

2. 论文

1) Gu F, Hu C, Tai Z, Yao C, Tian J, Zhang L, Xia Qing, Gong C, Gao Y*, Gao S* Tumour microenvironment-responsive lipoic acid nanoparticles for targeted delivery of docetaxel to lung cancer. Scientific Reports. 6: 36281. DOI: 10.1038/srep36281

2) Hu C, Gu F, Tai Z, Yao C, Gong C, Xia Q, Gao Y*, Gao S*. Synergistic effect of reduced polypeptide micelle for co-delivery of doxorubicin and TRAIL against drug-resistance in breast cancer. Oncotarget. 2016 doi: 10.18632/ 11451.

3) Liu Y, Wu X, Gao Y#, Zhang J, Zhang D, Gu S, Zhu G, Liu G, Li X*.Aptamer-functionalized peptide H3CR5C as a novel nanovehicle for codelivery of fasudil and miRNA-195 targeting hepatocellular carcinoma. Int J Nanomedicine. 2016:11, 3891–905

4) Yao C , Liu J, Wu X, Tai Z, Gao Y, Zhu Q, Li J, Zhang L, Hu C, Gu F, Gao J, Gao S*. Reducible self-assembling cationic polypeptide-based micelles mediate co-delivery of doxorubicin and microRNA-34a for androgen-independent prostate cancer therapy. J Control Release 232 (2016) 203–214.

5) Gao Y, Sarfraz M, Roa W, Clas S-D, L?benberg R*. Hyaluronic acid–tocopheryl succinate micelles containing rifampicin for active targeting to macrophages. J. Biomed. Nanotechnology. 11: 1-18 (2015)

6) Yao C, Tai Z, Wang X, Liu J, Quan G, Wu X, Zhang L, Zhang W, Gao Y*, Gao S*. Reduction-responsive cross-linked stearyl peptide for effective delivery of plasmid DNA. Int J Nanomedicine. 10: 3403–3416 (2015)

7) Tai Z, Wang X, Tian J, Gao Y, Zhang L, Yao C, Wu X, Zhang Wei, Zhu Q, Gao S *. Biodegradable Stearylated Peptide with Internal Disulfide Bonds for Efficient Delivery of siRNA In Vitro and In Vivo. Biomacromolecuous. 16: 4, 1119-1130 (2015)

8) Yao Y, Zhang M, Liu Tian,?Zhou J, Gao Y, Wen Z, Guan J, Zhu J, Lin Z, He D*. Perfluorocarbon-Encapsulated PLGA-PEG Emulsions as Enhancement Agents for Highly Efficient Reoxygenation to Cell and Organism. Applied Material Interfaces 7 (33), 18369–78. (2015)

9) Gao Y, Zuo J, Bou-Chacra N, Pinto T, Clas S, Walker, R, L?benberg, R*. In vitro release kinetics of anti- tuberculosis drugs from nanoparticles assessed using a modified dissolution apparatus. Biomed. Res. Inter. Published online, http://dx.doi.org/10.1155/2013/136590 (2013)

10) Gao Y, Ren FZ, Ding BY, Sun NY, Liu X, Ding XY, Gao S*. PLGA–PEG–PLGA-based hydrogel for sustained release of docetaxel. J. Drug Targeting 19: 516-527 (2011)

11) Gao Y, Sun Y, Ren FZ, Gao S*. PLGA-PEG-PLGA hydrogel for ocular drug delivery of dexamethasone acetate. Drug Dev. Ind. Pharm. 36: 1131–1138 (2010)

3.授权专利

1. CN101134036A含有雷贝拉唑和碳酸氢钠的制剂及其制备方法,2013.12授权

2. CN101444521B  包含阿仑膦酸钠和胆维丁的药物制剂, 2012.7授权

3. CN101199523A含有左旋氨氯地平和阿托伐他汀的药物组合物及制备方法,2012.9

4. CN1634045A 复方法莫替丁咀嚼片制备方法,2009.7授权

5. CN02145079含有盐酸西替利嗪和盐酸伪麻黄碱的制剂及其制备方法,2005.6授权

6. CN00125469 含嗜酸乳杆菌的药物制剂及制备方法,2005.7授权

7. CN200610147971.4 一种重组人表皮生长因子喷雾剂及其制备方法,2011.8.24授权

8. CN 200610147972 一种洋地黄提取物及其制备方法,2012.5.3授权

9. CN 2013100723608 温敏水凝胶及其制备方法和应用, 2016. 6.30 授权





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