段更利
药物分析, 教授 ,博士生导师

姓      名

 段更利

性      别

 男

职      称

 正高

学      历

 硕士

电      话

 13916903373

传      真

 51980053

电子邮件

 glduan@shmu.edu.cn

个人主页

 

通讯地址

 上海市浦东新区张衡路826号科研楼513室

教育经历 1973.09 – 1976.12 上海第一医学院药学系          本科
1982.01 – 1985.08 上海医科大学药物分析专业      硕士
 
工作经历 1977.02 – 1985.12 上海第一医学院,助教
1986.01 – 1993.12 上海医科大学,讲师
1994.01 – 1997.12 上海医科大学,副教授
1998.01 – 2000.08 上海医科大学,教授
2000.09 – 现在        复旦大学,教授

 

近年申请和授权专利
专利授权
1)一种测定硫普罗宁浓度的方法
专利号:200510029990.2  
2)中药陆英颗粒有效成分及含量的测定方法
专利号:200610023189.1
专利申请
1)一种离子液-红外辅助萃取中药中有效成分的方法
专利申请号ZL 201210204162.8
2)一种检测多种常见氨基酸的液相色谱方法
专利申请号 ZL 201110032844.0
3)一种多波长组合的指纹图谱检测方法及其用途
专利申请号 ZL 201110024325.X
4)DLLME法测有机溶剂残留
专利申请号 ZL 201010100167.7
6)红外辅助萃取在中药有效成分提取中的应用
专利申请号 ZL 200910201558.5
7)一种红外提取反应装置及其用途
专利申请号 ZL 200910196111.3


专家类别教授

职务博士生导师,教研室主任,第二党支部书记

 

主要科研贡献
1.主持上海市科委研究课题2项,主持创新药物质量标准或药代动力学研究共15项,授权专利4项,发表论文140余篇(其中SCI论文50余篇)。
2.培养的硕士生1人获上海市研究生优秀成果奖(学位论文), 1人获中国药学会主办“中国药学杂志岛津杯第六届药物分析优秀论文”一等奖。

 

承担科研项目情况
1.上海市科委研究课题2项
2.创新药物质量标准或药代动力学研究共15项


研究方向
1. 新药质量标准的制订
2. 样品前处理技术

 

 社会任职

 

 

2011.05 – 现在 

国家重点出版工程多媒体《中华医学百科全书》药物分析学卷、《药物分析杂志》、国家规划教材《药物分析》第4版~第8版(人民卫生出版社)编委

2006.01 – 现在

中国药学会上海分会药物分析专业委员会委员

2010.10 – 现在

食品药品监督管理局新药审评专家

2011.05 – 现在 

卫生部健康相关产品审评专家

 

上海药理学会药物代谢专业委员会委员

 
代表性论著

1)Feng JN,  Liu XD, Li Y, Duan GL*, Microwave-assisted enzymatic hydrolysis followed by extraction with restricted access nanocomposites for rapid analysis of glucocorticoids residues in liver tissue, Talanta, 2016,159:155-162.

2)Ling J,  Yu YJ,   Zhu JJ,  Li Y,  Ling L, Wang LP, Xu CJ, Duan GL*, A highly sensitive HPLCMS/MS method for quantification of 20(S)-protopanaxadiol in human plasma and its application in phase IIa clinical trial of a novel antidepressant agent, Journal of Chromatography B-Analytical Technologies in the Biomedical and Life Sciences,2016, 1031:214-220.

3)Liu XD,  Feng JN,  Sun XN,  Li Y, Duan GL*, Three-layer structure graphene/mesoporous silica composites incorporated with C8-modified interior pore-walls for residue analysis of glucocorticoids in milk by liquid chromatographytandem mass spectrometry, Analytica Chimica Acta, 2015,884:61-69.

4)Sun XN,  Liu XD,  Feng JN,   Li Y, Deng CH,  Duan GL*, Hydrophilic Nb5+-immobilized magnetic coreshell microsphere A novel immobilized metal ion affinity chromatography material for highly selective enrichment of phosphopeptides, Analytica Chimica Acta, 2015,880:67-76.

5)Sun XN,  Liu XD,  Feng JN,  Li Y,   Deng CH,   Duan GL*, Hydrophilic Nb5+-immobilized magnetic core-shell microsphere - A novel immobilized metal ion affinity chromatography material for highly selective enrichment of phosphopeptides, Analytica Chimica Acta, 2015,880:67-76.

6)Liu XD,   Feng JN,   Sun XN,  Li Y,   Duan GL*, Three-layer structure graphene/mesoporous silica composites incorporated with C8-modified interior pore-walls for residue analysis of glucocorticoids in milk by liquid chromatography-tandem mass spectrometry, Analytica Chimica Acta, 2015,884:61-69.

7)Xu C,  Zhu JJ,  Li Y,   Yu YJ,   Duan GL*, Fluorous solid-phase extraction (F-SPE) as a pilot tool for quantitative determination of perfluorochemicals in water samples coupled with liquid chromatography-tandem mass spectrometry, RSC Advances, 2015,5(17):13192-13199.

8)Liu XD, Yu YJ, Zhao MY, Zhang HY, Li Y, Duan GL*. Solid phase-extraction using magnetic core mesoporous shell microspheres with C18-modifiedinterior pore-walls for residue analysis of cephalosporins in milk by LC-MS/MS.Food Chem., 2014, 150: 206-212.
9)Liu XD, Yu YJ, Li Y, Ning SL, Liu TT, Li FJ, Duan GL*.Restricted access magnetic core-mesoporous shell microspheres with C8-modifiedinterior pore-walls for the determination of diazepam in rat plasma by LC-MS. Talanta,2013, 106: 321-327.
10)Li FJ, Yu YJ, Zhang HY, Liu TT, Li Y, Duan GL*. Infrared-assisted non-ionic surfactant extraction as a green analytical preparatory technique for the rapid extraction and pre-concentration of picroside Ⅰ and picroside Ⅱ from Picrorhiza scrophulariiflora Pennell. Anal. Methods, 2013,5: 3747-3753.
11)Li FJ, Ning SL, Li Y, Yu YJ, Duan GL*. Enhanced extraction of osthole and imperatorin from Cnidium monnieri by infrared-accelerated enzyme pretreatment. Anal. Methods, 2013, 5: 5669-5676.
12)Li FJ, Ning SL, Li Y, Yu YJ, Shen CD, Duan GL*. Optimisation of Infrared-assisted Extraction of Rutin from Crude FLos Sophorae Immaturus using Response surface methodology and HPLC analysis. Phytochem. Anal., 2012, 23: 292-298.
13)Li FJ, Zhang HY, Li Y, Yu YJ, Chen YL, Xie MF, Duan GL*. Simultaneous identification and quantification of dextran 20 and sucrose in lyophilized thrombin powder by size exclusion chromatography with ELSD. Chromatographia, 2012, 75: 187-191.
14)Zhou W, Xie MF, Zhang XY, Liu TT, Yu YJ, Duan GL*. Improved liquid chromatography fingerprint of fat-soluble Radix isatidis extract using multi-wavelength combination technique. J. Sep. Sci., 2011; 34: 1123-1132.
15)Xie MF, Zhou W, Tong XY, Chen YL, Cai Y, Li Y, Duan GL*. High-performance liquid chromatographic determination of memantine hydrochloride in rat plasma using sensitive fluorometric derivatization. J. Sep. Sci., 2011; 34: 241-246. 
16)Cai Y, Yu YJ, Duan GL*, Li Y. Study on infrared-assisted extraction coupled with high performance liquid chromatography (HPLC) for determination of catechin, epicatechin, and procyanidin B2 in grape seeds. Food Chem., 2011, 127: 1872-1877. 
17)Yu YJ, Chen B, Shen CD, Cai Y, Xie MF, Zhou W, Chen Y, Li Y, Duan GL*. Multiple headspace single-drop microextraction coupled with gas chromatography for direct determination of residual solvents in solid drug product. J. Chromatogr. A, 2010; 1217: 5158-5164.
18)Chen YL, Duan GL*, Xie MF, Chen B, Li Y. Infrared-assisted extraction coupled with high-performance liquid chromatography for simultaneous determination of eight active compounds in Radix Salviae miltiorrhizae. J. Sep. Sci., 2010; 33: 2888-2897. 
19)Zhou T, Yang B, Zhang HY, Yu YJ, Chen B, Chen YL, Duan GL*. Identification of Volatile Compounds in Chrysanthemum morifolium by Microwave Distillation Solid-Phase Microextraction Coupled with GC/MS. J. AOAC Int., 2009; 92: 855-861.
20)Yu YJ, Chen B, Chen YL, Xie MF, Duan HT, Li Y, Duan GL*.Nitrogen-protected microwave-assisted extraction of ascorbic acid from fruit and vegetables. J. Sep. Sci., 2009; 32: 4227-4233.
21)Zhou T, Zhang HY, Duan GL*. Simultaneous determination of diethylene glycol and propylene glycol in pharmaceutical products by HPLC after precolumn derivatization with p-toluenesulfonyl isocyanate. J. Sep. Sci., 2007; 30: 2620-2627.
22)Yu YJ, Huang TM, Yang B, Liu X, Duan GL*. Development of gas chromatography-mass spectrometry with microwave distillation and simultaneous solid-phase microextraction for rapid determination of volatile constituents in ginger. J. Pharm. Biomed. Anal., 2007; 43: 24-31. 
23)Yang B, Zhu JB, Deng CH, Duan GL*. Development of a sensitive and rapid liquid chromatography/tandem mass spectrometry method for the determination of apomorphine in canine plasma. Rapid Commun. Mass Spectrom., 2006; 20: 1883-1888. 
24)Yang B, Yu YQ, Cai L, Deng CH, Duan GL*. Determination of apomorphine in canine plasma by liquid chromatography-electrospray ionization mass spectrometry and its application to pharmacokinetic study. J. Sep. Sci., 2006; 29: 2173-2178. 
25)Huang TM, Yang B, Yu YJ, Zheng XW, Duan GL*. Reverse-phase high performance liquid chromatography for the determination of tiopronin in human plasma after derivatization with p-bromophenacyl bromide. Anal. Chim. Acta., 2006; 565: 178-182. 
26)Huang TM, He Z, Yang B, Shao LP, Zheng XW, Duan GL*. Simultaneous determination of captopril and hydrochlorothiazide in human plasma by reverse-phase HPLC from linear gradient elution. J. Pharm. Biomed. Anal., 2006; 41: 644-648. 
27)Huang TM, Deng CH, Chen N, Liu Z, Duan GL*. High performance liquid chromatography for the determination of glucosamine sulfate in human plasma after derivatization with 9-fluorenylmethyl chloroformate. J. Sep. Sci., 2006; 29: 2296-2302.
28)Deng CH, Lin S, Huang TM, Duan GL*, Zhang XM. Development of gas chromatography/mass spectrometry following headspace solid-phase microextraction for fast determination of asarones in plasma. Rapid Commun. Mass Spectrom., 2006; 20: 2120-2126.
29)Deng CH, Ji J, Li N, Yu YJ, Duan GL*, Zhang XM. Fast determination of curcumol, curdione and germacrone in three species of Curcuma rhizomes by microwave-assisted extraction followed by headspace solid-phase microextraction and gas chromatography-mass spectrometry. J. Chromatogr. A, 2006; 1117: 115-120. 

 

 

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