王建新
药剂学, 教授 ,博士生导师

姓      名

 王建新

性      别

 男

职      称

 教授

学      历

 博士

电      话

 021-51980088

传      真

 021-51980087

电子邮件

 jxwang@shmu.edu.cn

个人主页

 

通讯地址

 复旦大学张江校区药学院科研楼807室/西裙楼223室

 

个人简历

    1971年8月出生,1999年毕业于华西医科大学药学院药剂学专业,获博士学位。同年7月进入上海市中药研究所工作,2001年12月任高级工程师。

    2001年7月至2005年4月曾任上海市中药研究所常务副所长,2005年5月作为复旦大学引进人才进校工作。

    2009年7月至2010年8月于美国密西根大学药学院做访问学者。

    2007年6月至2013年1月担任复旦大学药学院药剂学教研室主任。

    2012年12月至今任复旦大学药学院副院长。

社会任职
    现任复旦大学药学院药剂学教授,药学院副院长、国家中医药管理局国家中医药管理局“中药制剂三级实验室”主任、复旦大学中西医结合研究院药物研究所所长、复旦大学-奥赛康药业联合研究中心主任。
研究成果
    先后主持国家及省部级研究课题30项,作为科研骨干参加“国家重大科学研究计划”和“重大新药创制”计划项目各2项;在国内外学术期刊发表论文170余篇;主编或副主编教材或专著6本,参编6本;作为项目负责人完成新药开发项目30余项,获新药证书或临床批件12项;获授权发明专利14项。

上海市精品课程《药物动力学》负责人,复旦大学《生物药剂学与药物动力学》课程首席教师。    

教材与专著
      1.《生物药剂学与药物动力学》主编,全国普通高等医学院校药学类专业“十三五”规划教材,中国医药科技出版社,2016年1月出版
      2.《药剂学》主编,国家“十二五”规划教材(临床药学专业用),人民卫生出版社,2015年4月出版
      3.《药剂学》副主编,国家“十二五”规划教材(药学类),高等教育出版社,2014年3月出版
      4.《现代药物动力学》副主编,人民卫生出版社,2011年12月出版
      5.《现代中药制剂设计理论与实践》副主编,人民卫生出版社,2010年5月出版
      6.《图解药剂学》副主编,人民卫生出版社,2008年12月出版

获奖及荣誉
     2002年荣获中国药学会第六届全国青年药学科技工作者最新科研成果学术交流会优秀论文一等奖。

     2002年荣获上海市 “讲理想、比贡献”十佳先进个人

     2003年被共青团上海市委员会授予“上海市新长征突击手”称号

     2004年被上海市人民政府授予2001~2003年度“上海市劳动模范”荣誉称号

     2004年6月被上海市国有资产管理委员会授予“优秀共产党员”荣誉称号

     2011年10月 获中国药学会-石药集团青年药剂学奖

     2014年5月 获上海市优秀技术带头人荣誉称号

社会兼职

     国家药品注册审评专家咨询委员会委员

     中国药学会药剂专委会委员

     世界中医药学会联合会新型给药系统专业委员会秘书长/常务理事

     中国生物医学工程学会纳米医学与工程分会委员

     中华中医药学会中药制剂分会常务理事

     上海市药学会理事

     上海市药学会中药专业委员会副主任委员

     上海市药学会药剂专业委员会

     上海市工程系列医药专业高级专业职务任职资格评审委员会委员

     《国际药学研究》、《中国医药工业杂志》、《中成药》、《药学研究》杂志编委


研究方向
    1. 靶向给药系统研究

           —基于细胞载药的脑部疾病靶向给药系统研究

           —克服药物穿透屏障的肿瘤靶向给药系统研究

     2. 口服给药系统设计及吸收机制研究

           —采用纳米技术(纳米粒、胶束、纳米共晶等)改善难溶性药物与大分子药物的口服吸收研究

           —改善药物口服生物利用度的制剂技术(热熔挤出、自乳化、磷脂复合物、固体分散体等)与机制研究

     3. 中药新型给药系统研究

           —中药缓控释、靶向给药系统研究

           —基于ADME的中药新剂型评价与组分中药研究

     4.  药物新制剂新剂型研究开发

           —口服固体制剂(普通制剂、缓控释制剂)研究开发

           —中药复方、有效部位、新剂型研究开发

           —外用制剂(巴布剂、软膏、贴剂)研究开发

代表性论著
1. Yingpeng Tong, Qin Zhang, Wen Shi and Jianxin Wang*. Mechanisms of oral absorption improvement for insoluble drugs by the combination of phospholipid complex and SNEDDS. Drug Delivery, 2019, 26 (1), 1155–1166
2. Jianming Liang, Ying Zhu, Caifang Gao, Chengli Ling, Jing Qin, Qi Wang, Yongzhuo Huang, Weigen Lu* and Jianxin Wang*. Menthol-modified BSA nanoparticles for glioma targeting therapy using an energy restriction strategy. NPG Asia Materials, 2019, 11:38 https://doi.org/10.1038/s41427-019-0138-6
3. Jia Hou#, Xu Yang#, Shiyi Li, Zhekang Cheng, Yuhua Wang, Jing Zhao, Chun Zhang,Yongji Li, Man Luo, Hongwei Ren, Jianming Liang, Jue Wang, Jianxin Wang*, Jing Qin*. Accessing neuroinflammation sites: Monocyte/neutrophil-mediated drug delivery for cerebral ischemia. Science Advances, 2019;5: eaau8301
4. Wenxue Mao, Fan Wu, Robert J Lee, Weigen Lu*, Jianxin Wang*. Development of a stable single-vial liposomal formulation for vincristine. International Journal of Nanomedicine, 2019:14 4461–4474
5. Hongwei Ren, Yuwei He, Jianming Liang, Zhekang Cheng, Meng Zhang, Ying Zhu, Chao Hong, Jing Qin, Xinchun Xu*, Jianxin Wang*. Role?of?Liposome Size, Surface Charge, and PEGylation on Rheumatoid Arthritis Targeting Therapy. ACS Applied Materials &Interfaces,  2019,  11, 22, 20304-20315
6. Chao Hong#, Dan Wang#, Jianming Liang, Yizhen Guo, Ying Zhu, Jiaxuan Xia, Jing Qin, Huaxing Zhan, Jianxin Wang*. Novel ginsenoside-based multifunctional liposomal delivery system for combination therapy of gastric cancer. Theranostics, 2019, 9(15): 4437-4449
7. Yuwei He#,Ruixiang Li#, Haichun Li, Shuya Zhang,Wentao Dai, Qian Wu, Lixian Jiang, Zicong Zheng, Shun Shen, Xing Chen, Yuefei Zhu, Jianxin Wang* and Zhiqing Pang*. Erythroliposomes: Integrated Hybrid Nanovesicles Composed of Erythrocyte Membranes and Artificial Lipid Membranes for Pore-Forming Toxin Clearance. ACS Nano, 2019, 13, 4148?4159
8. Ruixiang Li#, Yuwei He#, Ying Zhu, Lixian Jiang, Shuya Zhang, Jing Qin, Qian Wu, Wentao Dai, Shun Shen, Zhiqing Pang* and Jianxin Wang*. Route to Rheumatoid Arthritis by Macrophage derived Microvesicle-Coated Nanoparticles. Nano Letters, 2019, 19 (1), pp 124–134
9. Caifang Gao, Jianming Liang, Ying Zhu, Chengli Ling, Zhekang Cheng, Ruixiang Li, Jing Qin, Weigen Lu*, Jianxin Wang*. Menthol-modified casein nanoparticles loading 10-hydroxycamptothecin for glioma targeting therapy. Acta Pharmaceutica Sinica B, 2019, https://doi.org/10.1016/j.apsb.2019.01.006
10. Zhekang Cheng, Meng Zhang, Chengli Ling, Ying Zhu, Hongwei Ren, Chao Hong, Jing Qin, Tongxiang Liu* and Jianxin Wang*. Neuroprotective Effects of Ginsenosides against Cerebral Ischemia. Molecules 2019, 24, 1102; doi:10.3390/molecules24061102
11. Liang Pang, Ying Zhu, Jing Qin, Wenjie Zhao and Jianxin Wang*. Primary M1 macrophages as multifunctional carrier combined with PLGA nanoparticle delivering anticancer drug for efficient glioma therapy. Drug Delivery, 2018, 25(1), 1922–1931
12. Jianming Liang, Caifang Gao, Ying Zhu, Chengli Ling, Qi Wang, Yongzhuo Huang, Jing Qin, Jue Wang, Weigen Lu*, and Jianxin Wang*. Natural Brain Penetration Enhancers Modified Albumin Nanoparticles for Glioma Targeting Delivery. ACS Applied Materials &Interfaces,  2018, 10 (36):30201–30213
13. Yuwei He, Ruixiang Li, Jianming Liang, Ying Zhu, Shuya Zhang, Zicong Zheng, Jing Qin, Zhiqing Pang* and Jianxin Wang*. Platelet membrane-coated nanoparticles for rheumatoid arthritis targeting. Nano Research, 2018, 11(11): 6086–6101
14. Jianming Liang, Ruixiang Li, Yuwei He, Chengli Ling, Qi Wang, Yongzhuo Huang, Weigen Lu*, Jianxin Wang*. A Novel Tumor Targeting Treatment Strategy through Energy Restriction by Co-delivery of Albendazole and Nano-silver. Nano Research, 2018, 11: 4507-4523
15. Ruixiang Li#, Yuwei He#, ShuyaZhang, JingQin, Jianxin Wang*. Cell membrane based nanoparticles: a new biomimetic platform for tumor diagnosis and treatment. Acta Pharmaceutica Sinica B 2018;8(1):14–22
16. Ruixiang Li, Jianming Liang, Yuwei He, Jing Qin, Huining He, Seungjin Lee, Zhiqing Pang* and Jianxin Wang*. Sustained Release of Immunosuppressant by Nanoparticle-anchoring Hydrogel Scaffold Improved the Survival of Transplanted Stem Cells and Tissue Regeneration. Theranostics, 2018; 8(4): 878-893
17. Yisi Tang, Jianming Liang, Aihua Wu, Yingzhi Chen, Pengfei Zhao, Tingting Lin, Meng Zhang, Qin Xu, Jianxin Wang* and Yongzhuo Huang*. Co-Delivery of Trichosanthin and Albendazole by Nano-Self- Assembly for Overcoming Tumor Multidrug-Resistance and Metastasis. ACS Appl Mater Interfaces 2017, 9(32):26648-26664
18. Chun Zhang, Chengli Ling, Liang Pang, Qi Wang, Jingxin Liu, Bingshan Wang, Jianming Liang, Jing Qin*, Jianxin Wang*. Direct macromolecular drug to cerebral ischemia area using Neutrophil mediated nanoparticles. Theranostics, 2017,7(13):3260-3275
19. Ruixiang Li, Zhiqing Pang, Huining He, Seungjin Lee, Jing Qin, Jian Wu, Liang Pang, Jianxin Wang* and Victor C. Yang*. Drug depot-anchoring hydrogel: A self-assembling scaffold for localized drug release and enhanced stem cell differentiation. Journal of Controlled Release, 2017, 261:234-245
20. Ziqing Duan, Cuitian Chen, Jing Qin, Qi Liu, Qi Wang, Xinchun Xu* and Jianxin Wang*. Cell-penetrating peptide conjugates to enhance the antitumor effect of paclitaxel on drug-resistant lung cancer. Drug Delivery, 2017, 24(1):752-764
21. Cuitian Chen, Ziqing Duan, Ruixiang Li, Liang Pang, Yan Yuan, Jianming Liang, Xinchun Xu* and Jianxin Wang*. Peptide-22 and cyclic RGD functionalized liposomes for glioma targeting drug delivery overcoming BBB and BBTB. ACS Appl Mater Interfaces. 2017, 9:5864-5873
22. Liang Pang, Chun Zhang, Jing Qin, Limei Han, Ruixiang Li, Huining He and Jianxin Wang*. A novel strategy to achieve effective drug delivery: exploit cells as carrier combined with nanoparticles. Drug Delivery, 2017; 24(1): 83–91
23. Jianyong Sheng , Huining He, Limei Han, Jing Qi, Sunhui Chen, Ge Ru, Ruixiang Li, Pei Yang, Jianxin Wang* and Victor C. Yang*. Enhancing Insulin Oral Absorption by Using Mucoadhesive Nanoparticles Loaded with LMWP-linked Insulin Conjugates. Journal of Controlled Release,2016,233:181-190
24. Ge Ru, Limei Han, Jing Qin, Jianyong Sheng, Ruixiang Li, Mingfeng Qiu and Jianxin Wang*. Effects of borneol on the pharmacokinetics of 9-nitrocamptothecin encapsulated in PLGA nanoparticles with different size via oral administration. Drug Delivery. 2016; 23(9): 3417–3423
25. Jianyong Sheng, Limei Han, Jing Qin, Ge Ru, Ruixiang Li, Lihong Wu, Dongqi Cui, Pei Yang, Yuwei He, Jianxin Wang*. N-Trimethyl Chitosan Chloride-Coated PLGA Nanoparticles Overcoming Multiple Barriers to Oral Insulin Absorption. ACS Appl Mater Interfaces. 2015, (28) 7:15430-41
26. Jing Qin,Xu Yang,Ruoxi Zhang,Yixiao Luo,Jiali Li,Jia Hou,Chun Zhang,Yongji Li,Jie Shi,Lin Lu,Jianxin Wang*,Wei-Li Zhu*. Monocyte mediated brain targeting delivery of macromolecular drug for the therapy of depression.,Nanomedicine: Nanotechnology, Biology and Medicine,2015,11(2):391-400
27. Limei Han, Qiushi Yang, Teng Shen, Jin Qing, Jianxin Wang*. Lymphatic transport of orally administered probucol-loaded mPEG-DSPE micelles. Drug Delivery, 2015:25:1-7
28. Huining He, Jianyong Sheng, Allan E David, Youngmin Kwon, Jian Zhang, Yongzhuo Huang,  Jianxin Wang*,Victor C Yang*. The use of low molecular weight protamine chemical chimera to enhance monomeric insulin intestinal absorption. Biomaterials, 2013, 34(31):7733-7743
29. Lin Zhang, Limei Han, Jing Qin, Weiyue Lu and Jianxin Wang*. Borneol as an Enhancer for Targeting Aprotinin-Conjugated PEG-PLGA Nanoparticles to the Brain. Pharmaceutical research, 2013, 30(10) : 2560-72
30. Ming Shen, Yongzhuo Huang, Limei Han, Jing Qin, Xiaoling Fang, Jianxin Wang *, Victor C Yang*. Multifunctional drug delivery system for targeting tumor and its acidic microenvironment. Journal of Controlled Release, 2012, 161:884-892

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